Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly

Elena Nazarova,E. O'Toole,Susanne Kaitna,P. François,M. Winey,J. Vogel

Published 2013 in Molecular Biology of the Cell

ABSTRACT

Correlation of spindle architecture with dynamic behavior shows that pairs of antiparallel microtubules are sufficient to form a bipolar spindle, whereas interpolar microtubules maintain the speed of pole displacement during spindle assembly. The number of interpolar microtubules formed is controlled in part through γ-tubulin phosphorylation.

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