The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cell Science

• Publication date

  2011-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.081711PMID 21693576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of ATR-mediated checkpoint signalling.

  2010cited by this paper
• Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis

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• Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1

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• Genome-wide mapping of meiotic DNA double-strand breaks in Saccharomyces cerevisiae.

  2009cited by this paper
• DNA double-strand breaks in meiosis: checking their formation, processing and repair.

  2009cited by this paper
• Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates.

  2009cited by this paper
• Drosophila PCH2 Is Required for a Pachytene Checkpoint That Monitors Double-Strand-Break-Independent Events Leading to Meiotic Crossover Formation

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• Sequential Assembly of Centromeric Proteins in Male Mouse Meiosis

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• Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.

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• Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.

  2008influential reference
• Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Polζ/Rev1

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• Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.

  2008cited by this paper
• Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes

  2007cited by this paper
• Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response.

  2007influential reference
• Checking your breaks: surveillance mechanisms of meiotic recombination.

  2006cited by this paper
• Surviving the breakup: the DNA damage checkpoint.

  2006cited by this paper
• Mnd1/Hop2 Facilitates Dmc1-Dependent Interhomolog Crossover Formation in Meiosis of Budding Yeast

  2006cited by this paper
• Protocol for the fast chromatin immunoprecipitation (ChIP) method

  2006cited by this paper
• Balancing the checks: surveillance of chromosomal exchange during meiosis.

  2006cited by this paper
• Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in budding yeast.

  2006cited by this paper
• Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.

  2005cited by this paper
• Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

  2005cited by this paper
• ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.

  2005cited by this paper
• The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity.

  2005cited by this paper
• Specific Association of Mouse MDC1/NFBD1 with NBS1 at Sites of DNA-Damage

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• A Conserved Checkpoint Monitors Meiotic Chromosome Synapsis in Caenorhabditis elegans

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• Surveillance of Different Recombination Defects in Mouse Spermatocytes Yields Distinct Responses despite Elimination at an Identical Developmental Stage

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• The evolution of meiosis: Recruitment and modification of somatic DNA‐repair proteins

  2005cited by this paper
• ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.

  2004cited by this paper
• TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.

  2004cited by this paper
• Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I

  2004cited by this paper
• Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.

  2004cited by this paper
• Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

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• Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis.

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• Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

  2004influential reference
• Un ménage à quatre: the molecular biology of chromosome segregation in meiosis.

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• Title The recombination-deficient mutant RPA ( rfa 1t 11 ) is displaced slowly from single-stranded DNA by Rad 51 protein

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• Specific arrests of spermatogenesis in genetically modified and mutant mice.

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• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003influential reference
• The importance of genetic recombination for fidelity of chromosome pairing in meiosis.

  2003cited by this paper
• The Recombination-deficient Mutant RPA (rfa1-t11) Is Displaced Slowly from Single-stranded DNA by Rad51 Protein*

  2003cited by this paper
• Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.

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  2003cited by this paper
• Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.

  2003cited by this paper
• Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre

  2003cited by this paper
• The Mnd1 Protein Forms a Complex with Hop2 To Promote Homologous Chromosome Pairing and Meiotic Double-Strand Break Repair

  2002cited by this paper
• The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

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• Role of Ndt80, Sum1, and Swe1 as Targets of the Meiotic Recombination Checkpoint That Control Exit from Pachytene and Spore Formation in Saccharomyces cerevisiae

  2002cited by this paper
• The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in fission yeast

  2002cited by this paper
• A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.

  2002influential reference
• Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.

  2002cited by this paper
• Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms

  2001cited by this paper
• A DNA damage response pathway controlled by Tel1 and the Mre11 complex.

  2001influential reference
• Two checkpoint complexes are independently recruited to sites of DNA damage in vivo.

  2001influential reference
• To err (meiotically) is human: the genesis of human aneuploidy

  2001cited by this paper
• The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80.

  2000cited by this paper
• Role for the silencing protein Dot1 in meiotic checkpoint control.

  2000cited by this paper
• Bypass of a Meiotic Checkpoint by Overproduction of Meiotic Chromosomal Proteins

  2000cited by this paper
• The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.

  2000cited by this paper
• The pachytene checkpoint.

  2000cited by this paper
• Meiotic Segregation, Synapsis, and Recombination Checkpoint Functions Require Physical Interaction between the Chromosomal Proteins Red1p and Hop1p

  2000cited by this paper
• The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.

  2000influential reference
• The association of ATR protein with mouse meiotic chromosome cores

  1999cited by this paper
• Sister chromatid‐based DNA repair is mediated by RAD54, not by DMC1 or TID1

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  1999influential reference
• The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.

  1998influential reference
• Squash Procedure for Protein Immunolocalization in Meiotic Cells

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• Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Meiotic chromosomes: it takes two to tango.

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  1997cited by this paper
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  1996influential reference
• The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

  1996influential reference
• Roles for two RecA homologs in promoting meiotic chromosome synapsis.

  1995cited by this paper
• Crossover interference is abolished in the absence of a synaptonemal complex protein.

  1994cited by this paper
• Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction.

  1994cited by this paper
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  1994cited by this paper
• ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis.

  1993cited by this paper
• DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.

  1992cited by this paper
• A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.

  1991cited by this paper
• Meiosis in asynaptic yeast.

  1990cited by this paper
• Uva-dare (digital Academic Repository) Mouse Trip13/pch2 Is Required for Recombination and Normal Higher-order Chromosome Structure during Meiosis Mouse Trip13/pch2 Is Required for Recombination and Normal Higher-order Chromosome Structure during Meiosis

  year unknowncited by this paper

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