The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Development

• Publication date

  2012-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.074070PMID 22461565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The Developmental Transcriptome of Drosophila melanogaster

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  2010influential reference
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  2009influential reference
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  2009cited by this paper
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  2008influential reference
• Alternative Isoform Regulation in Human Tissue Transcriptomes

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• Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

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  2007influential reference
• Neuron-glial interactions in blood-brain barrier formation.

  2007cited by this paper
• InParanoid 6: eukaryotic ortholog clusters with inparalogs

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  2003cited by this paper
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• The Clf1p Splicing Factor Promotes Spliceosome Assembly through N-terminal Tetratricopeptide Repeat Contacts*

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• Epidermal growth factor receptor: mechanisms of activation and signalling.

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• Signal-dependent regulation of splicing via phosphorylation of Sam68

  2002influential reference
• Function of quaking in myelination: Regulation of alternative splicing

  2002cited by this paper
• Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors.

  2002cited by this paper
• Nuclear retention of MBP mRNAs in the quaking viable mice.

  2002cited by this paper
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  2001cited by this paper
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  2000influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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