Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Protein Science

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1110/ps.073427208PMID 18369191PMCID PMC2327289
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inference of macromolecular assemblies from crystalline state.

  2007cited by this paper
• Regulation of Ornithine Decarboxylase*

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• Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism

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• So how do you know you have a macromolecular complex?

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• Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions

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• Degradation of Antizyme Inhibitor, an Ornithine Decarboxylase Homologous Protein, Is Ubiquitin-dependent and Is Inhibited by Antizyme*

  2004cited by this paper
• A dissection of specific and non-specific protein-protein interfaces.

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• Inhibitors of polyamine metabolism: Review article

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• Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin‐independent substrate

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• Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function.

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• Altering the reaction specificity of eukaryotic ornithine decarboxylase.

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• Structural symmetry and protein function.

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• Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.

  2000cited by this paper
• Identification of differentially expressed genes in normal and tumor human gastric tissue.

  2000cited by this paper
• Properties of a polyamine transporter regulated by antizyme.

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• Processing of X-ray diffraction data collected in oscillation mode.

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• Cloning of Antizyme Inhibitor, a Highly Homologous Protein to Ornithine Decarboxylase (*)

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• Structural motifs for pyridoxal‐5′‐phosphate binding in decarboxylases: An analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase

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• Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.

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• Polyamines as targets for therapeutic intervention.

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• Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme

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• Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting.

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• Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells.

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• Intersubunit location of the active site of mammalian ornithine decarboxylase as determined by hybridization of site-directed mutants.

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• Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.

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• Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein

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• Electronic Reprint Biological Crystallography Automated Main-chain Model Building by Template Matching and Iterative Fragment Extension

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• Impact of Ornithine Decarboxylase on Semen Parameters and Functional Status of Spermatozoa in Type 2 Diabetes Mellitus

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• Protein degradation, the main hub in the regulation of cellular polyamines.

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• Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma.

  2015cites this paper
• Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

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• Structural basis of antizyme-mediated regulation of polyamine homeostasis

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• Functional Roles of the Dimer-Interface Residues in Human Ornithine Decarboxylase

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