Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer’s

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Applied Genetics

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13353-010-0021-1PMID 21170692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
• Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway.

  2010cited by this paper
• Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface its increased processing through the -secretase pathway

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• Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.

  2010cited by this paper
• Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

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• Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

  2009cited by this paper
• Impact of cholesterol level upon APP and BACE proximity and APP cleavage.

  2008influential reference
• Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

  2008cited by this paper
• Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

  2008cited by this paper
• Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.

  2008influential reference
• A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

  2007cited by this paper
• Plaque-Derived Oxidative Stress Mediates Distorted Neurite Trajectories in the Alzheimer Mouse Model

  2006cited by this paper
• Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling

  2006cited by this paper
• Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.

  2004cited by this paper
• Neuronal membrane cholesterol loss enhances amyloid peptide generation

  2004cited by this paper
• Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

  2004cited by this paper
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  2002cited by this paper
• Mouse models of Alzheimer's disease: a quest for plaques and tangles.

  2002cited by this paper
• Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.

  2002cited by this paper
• A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.

  2001cited by this paper
• Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells*

  2001cited by this paper
• Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

  2000cited by this paper
• Identification of HE1 as the second gene of Niemann-Pick C disease.

  2000cited by this paper
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  2000influential reference
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

  1998cited by this paper
• Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

  1998cited by this paper
• Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol*

  1998cited by this paper
• Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.

  1997cited by this paper
• Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.

  1997cited by this paper
• Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids

  1997cited by this paper
• Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Cholesterol Modulates -Secretase Cleavage of Amyloid Precursor Protein (*)

  1996cited by this paper
• Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein.

  1996cited by this paper
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  1987cited by this paper

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  2025cites this paper
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  2025cites this paper
• Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage

  2021cites this paper
• Role of Autophagy in Phosphatidyl- Glycerol Facilitated Cholesterol Clearance from the Endolysosomal System of Npc-1 Deficient Cells

  2021cites this paper
• Niemann-Pick Type C Disease: At the Nexus of Neurodegenerative and Neurodevelopmental Disorders

  2020cites this paper
• Sphingolipids in neurodegeneration (with focus on ceramide and S1P).

  2018cites this paper
• Do GWAS and studies of heterozygotes for NPC1 and/or NPC2 explain why NPC disease cases are so rare?

  2018cites this paper
• Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

  2017cites this paper
• Modeling Niemann Pick type C1 using human embryonic and induced pluripotent stem cells.

  2017influential citation
• The lysosomal storage disease continuum with ageing-related neurodegenerative disease.

  2016cites this paper
• Neurological Dysfunction in Early Maturity of a Model for Niemann–Pick C1 Carrier Status

  2016cites this paper
• EXPLORING THE ROLE OF MITOCHONDRIAL CHOLESTEROL IN NIEMANN-PICK TYPE C DISEASE

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• QUANTITATIVE MEASUREMENT OF THE EXPRESSION OF TWO GENES IN THE CORETX AND CEREBELLUM OF A MOUSE MODEL OF JUVENILE ALZHEIMER’S

  2016cites this paper
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  2014cites this paper
• Mutations in Niemann Pick type C gene are risk factor for Alzheimer's disease.

  2014cites this paper
• Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease

  2014cites this paper
• Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology

  2014cites this paper
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