Identification of a Misfolded Region in Superoxide Dismutase 1 That Is Exposed in Amyotrophic Lateral Sclerosis*

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Biological Chemistry

• Publication date

  2014-08-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M114.581801PMID 25164820PMCID PMC4192504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Non-native Soluble Oligomers of Cu/Zn Superoxide Dismutase (SOD1) Contain a Conformational Epitope Linked to Cytotoxicity in Amyotrophic Lateral Sclerosis (ALS)

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• Amyotrophic lateral sclerosis: Problems and prospects

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• Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

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• A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis‐linked SOD1 mutants

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• Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.

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• Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS

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• Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

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• Oxidative Modification of Cysteine 111 Promotes Disulfide Bond-Independent Aggregation of SOD1

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• Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

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• Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis*

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• Metal-free Superoxide Dismutase-1 and Three Different Amyotrophic Lateral Sclerosis Variants Share a Similar Partially Unfolded β-Barrel at Physiological Temperature*

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• Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

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• Decreased Metallation and Activity in Subsets of Mutant Superoxide Dismutases Associated with Familial Amyotrophic Lateral Sclerosis* 210

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• Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

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