Prothrombotic Effects of Fibronectin Isoforms Containing the EDA Domain

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2007-11-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.107.149146PMID 17991876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

  2015cited by this paper
• A Major Fraction of Fibronectin Present in the Extracellular Matrix of Tissues Is Plasma-derived*

  2007cited by this paper
• von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins.

  2006cited by this paper
• Decreased Plasma Fibronectin Leads to Delayed Thrombus Growth in Injured Arterioles

  2006cited by this paper
• Systemic antithrombotic effects of ADAMTS13

  2006cited by this paper
• Role of fibronectin assembly in platelet thrombus formation

  2006cited by this paper
• Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi.

  2006cited by this paper
• Plasma Cellular-Fibronectin Concentration Predicts Hemorrhagic Transformation After Thrombolytic Therapy in Acute Ischemic Stroke

  2004cited by this paper
• From bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 23, 2013. For personal use only.

  2004cited by this paper
• Alternative splicing of fibronectin: a mouse model demonstrates the identity of in vitro and in vivo systems and the processing autonomy of regulated exons in adult mice.

  2004cited by this paper
• Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan

  2003cited by this paper
• Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A

  2003cited by this paper
• Plasma fibronectin promotes thrombus growth and stability in injured arterioles

  2003cited by this paper
• The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.

  2002cited by this paper
• Fibronectin at a glance

  2002cited by this paper
• NMR structure of human fibronectin EDA.

  2001cited by this paper
• Plasma levels of cellular fibronectin in diabetes.

  2001cited by this paper
• Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

  2001cited by this paper
• Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.

  2000cited by this paper
• Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen.

  2000cited by this paper
• The Compact Conformation of Fibronectin Is Determined by Intramolecular Ionic Interactions*

  1999cited by this paper
• von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura.

  1999cited by this paper
• Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow*

  1999cited by this paper
• Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

  1998cited by this paper
• Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment

  1997cited by this paper
• Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.

  1996cited by this paper
• The fibronectin gene as a model for splicing and transcription studies

  1996cited by this paper
• Alternative splicing of fibronectin--many different proteins but few different functions.

  1995cited by this paper
• Release of ED1 fibronectin from matrix of perfused lungs after vascular injury is independent of protein synthesis.

  1993cited by this paper
• Absence of endonuclease activation during acute cell death in renal proximal tubules.

  1993cited by this paper
• The alternatively spliced V region contributes to the differential incorporation of plasma and cellular fibronectins into fibrin clots

  1992cited by this paper
• Elevated plasma levels of ED1+ ("cellular") fibronectin in patients with vascular injury.

  1989cited by this paper
• Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon.

  1987cited by this paper
• Cell-type-specific fibronectin subunits generated by alternative splicing.

  1986cited by this paper
• Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

  1985cited by this paper
• A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon.

  1984cited by this paper
• Cross-linking of cold-insoluble globulin by fibrin-stabilizing factor.

  1975cited by this paper

• Myocardial ischemia-reperfusion injury released cellular fibronectin containing domain A (CFN-EDA): A destructive positive loop amplifying arterial thrombosis formation and exacerbating myocardial reperfusion injury.

  2024cites this paper
• Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia

  2023cites this paper
• The role of extracellular traps in ischemia reperfusion injury

  2022cites this paper
• The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation

  2021cites this paper
• Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen

  2021cites this paper
• Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation

  2020cites this paper
• Imaging Platelet Processes and Function—Current and Emerging Approaches for Imaging in vitro and in vivo

  2020cites this paper
• Frontiers of Immunology Imaging platelet processes and function – current and emerging approaches for imaging in vitro and in vivo

  2020cites this paper
• Cellular fibronectin promotes deep vein thrombosis in diet‐induced obese mice

  2020cites this paper
• Updated understanding of platelets in thrombosis and hemostasis: the roles of integrin PSI domains and their potential as therapeutic targets.

  2020cites this paper
• Fn-EDA (Fibronectin Containing Extra Domain A) in the Plasma, but Not Endothelial Cells, Exacerbates Stroke Outcome by Promoting Thrombo-Inflammation

  2019cites this paper
• Increased blood levels of cellular fibronectin in asthma: Relation to the asthma severity, inflammation, and prothrombotic blood alterations.

  2018cites this paper
• Time‐dependent changes in extra‐domain A‐fibronectin concentration and relative amounts of fibronectin‐fibrin complexes in plasma of patients with peripheral arterial disease after endovascular revascularisation

  2018influential citation
• The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease.

  2018cites this paper
• Deletion of Extra Domain A of Fibronectin Reduces Acute Myocardial Ischaemia/Reperfusion Injury in Hyperlipidaemic Mice by Limiting Thrombo-Inflammation

  2018cites this paper
• Alternatively spliced fibronectin extra domain A is required for hemangiogenic recovery upon bone marrow chemotherapy

  2017cites this paper
• Platelet Activation Under Conditions of Flow

  2017cites this paper
• Fibronectin maintains the balance between hemostasis and thrombosis

  2016cites this paper
• Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis

  2016cites this paper
• Occurrence of fibronectin-fibrin complexes in plasma of patients with multimorbidity due to the inflamm-aging phenomenon.

  2016cites this paper
• Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice.

  2015cites this paper
• THROMBOSIS AND HEMOSTASIS Cellular fi bronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4

  2015cites this paper
• Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation

  2015cites this paper
• Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity

  2015cites this paper
• Expression of the fibrillin gene family in the development, differentiation and maintenance of mesenchyme cell types

  2015cites this paper
• Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery.

  2015cites this paper
• Interaction of von Willebrand factor with platelets and the vessel wall

  2015cites this paper
• The importance of fibronectin in development, regeneration and treatment: review article

  2015cites this paper
• Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4.

  2015cites this paper
• Plasma Fibronectin in Hemostasis and Thrombosis: Evidence for fibrin-dependent and independent pathways

  2015cites this paper
• Fibronectin: extra domain brings extra risk?

  2015cites this paper
• Etude de l’adhésion de vésicules géantes et de cellules vivantes par nanoscopie de fluorescence

  2015cites this paper
• Etude du rôle des étapes initiales d'adhérence des plaquettes sanguines et du flux pulsatile dans l'agrégation plaquettaire

  2014cites this paper
• Alternative Splicing of Endothelial Fibronectin Is Induced by Disturbed Hemodynamics and Protects Against Hemorrhage of the Vessel Wall

  2014cites this paper
• A Regulatory Loop between β-Catenin and Extra-cellular Matrix Components during the Proliferative Phase of Cutaneous Wound Healing

  2014cites this paper
• Chapter 20 – Platelet Thrombus Formation in Flowing Blood

  2013cites this paper
• Extra-domain B in Oncofetal Fibronectin Structurally Promotes Fibrillar Head-to-tail Dimerization of Extracellular Matrix Protein*

  2012cites this paper
• Extracellular matrix proteins in hemostasis and thrombosis.

  2012cites this paper
• Alternatively-Spliced Extra Domain A of Fibronectin Promotes Acute Inflammation and Brain Injury After Cerebral Ischemia in Mice

  2012cites this paper
• Regulation of in the context of cell nucleus

  2011cites this paper
• Evolutionary connections between coding and splicing regulatory regions in the fibronectin EDA exon.

  2011cites this paper
• Plasma and cellular fibronectin: distinct and independent functions during tissue repair

  2011cites this paper
• Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies.

  2011cites this paper
• Fibronectin splice variants: Understanding their multiple roles in health and disease using engineered mouse models

  2011cites this paper
• Psoriasis and extra domain A fibronectin loops

  2010cites this paper
• Plasma Factors as Endogenous Agonists and Modulators of TLR4 Signaling in Microglia

  2010cites this paper
• Emerging roles of fibronectin in thrombosis.

  2010cites this paper
• Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.

  2009cites this paper
• Platelet activation by extracellular matrix proteins in haemostasis and thrombosis.

  2009cites this paper
• Platelet Adhesion under Flow

  2009cites this paper
• Genetics and molecular biology: variations in alternative spliced pre-mRNA-protein isoforms and their role in disease.

  2008cites this paper
• The role of integrin binding sites in fibronectin matrix assembly in vivo.

  2008cites this paper
• Elevated plasma fibronectin levels associated with venous thromboembolism

  2008cites this paper
• New insights into form and function of fibronectin splice variants

  2008influential citation
• Adding complexity to fibronectin-platelet interactions.

  2007cites this paper