Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity

No abstract is available for this paper.

• Publication year

  2018

• Venue

  New Journal of Chemistry

• Publication date

  2018-04-16

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/C7NJ04271J
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Antiproliferative and antimicrobial efficacy of the compounds isolated from the roots of Oenothera biennis L.

  2017cited by this paper
• Characterization of bioactive constituents from the gum resin of Gardenia lucida and its pharmacological potential.

  2017cited by this paper
• Diastereoselective Synthesis of β‐Ether Derivatives of Artemisinin, an Antimalarial Drug: The Effect of Nitrile on Stereoselectivity

  2016cited by this paper
• Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?

  2016cited by this paper
• Synthesis of a series of novel dihydroartemisinin monomers and dimers containing chalcone as a linker and their anticancer activity.

  2016cited by this paper
• Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models.

  2015cited by this paper
• Synthesis of cyclic 1,9-acetal derivatives of forskolin and their bioactivity evaluation.

  2014cited by this paper
• Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008 – 2011)

  2013cited by this paper
• Pharmacological significance of triazole scaffold

  2011cited by this paper
• Click chemistry: 1,2,3-triazoles as pharmacophores.

  2011cited by this paper
• Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo

  2011cited by this paper
• In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents

  2011cited by this paper
• Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production*

  2010cited by this paper
• The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials*

  2010cited by this paper
• Heme as trigger and target for trioxane-containing antimalarial drugs.

  2010cited by this paper
• Drug interactions involving the new second- and third-generation antiepileptic drugs

  2010cited by this paper
• Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo.

  2010cited by this paper
• Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents.

  2010cited by this paper
• Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells

  2010cited by this paper
• Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.

  2010cited by this paper
• Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

  2009cited by this paper
• Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

  2008cited by this paper
• Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent

  2008cited by this paper
• Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation.

  2008cited by this paper
• Pharmacokinetic and Pharmacodynamic Profiles of Rapid-Acting Artemisinins in the Antimalarial Therapy

  2007cited by this paper
• Dihydroartemisinin is an inhibitor of ovarian cancer cell growth

  2007cited by this paper
• Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds*

  2007cited by this paper
• Inhibitors of HIV-1 protease by using in situ click chemistry.

  2006cited by this paper
• Targeted induction of apoptosis for cancer therapy: current progress and prospects.

  2006cited by this paper
• Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells.

  2005cited by this paper
• Artesunate in the treatment of metastatic uveal melanoma--first experiences.

  2005cited by this paper
• Anti-cancer drugs: molecular mechanisms of action.

  2005cited by this paper
• Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil

  2004cited by this paper
• Molecular modes of action of artesunate in tumor cell lines.

  2003cited by this paper
• Deoxyartemisinin derivatives from photooxygenation of anhydrodeoxydihydroartemisinin and their cytotoxic evaluation.

  2002cited by this paper
• Modulation of multidrug resistance by artemisinin, artesunate and dihydroartemisinin in K562/adr and GLC4/adr resistant cell lines.

  2002cited by this paper
• Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer

  2000cited by this paper
• NMR and conformational studies of the antimalarial drug arte-ether

  1999cited by this paper
• Artemisinin-Derived Sesquiterpene Lactones as Potential Antitumour Compounds: Cytotoxic Action against Bone Marrow and Tumour Cells

  1998cited by this paper
• Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

  1996cited by this paper
• HIV resistance to reverse transcriptase inhibitors

  1994cited by this paper
• Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells.

  1993cited by this paper
• Microbial metabolism studies of the antimalarial sesquiterpene artemisinin.

  1989cited by this paper
• Thermal rearrangement and decomposition products of artemisinin (qinghaosu)

  1985cited by this paper
• Qinghaosu (artemisinin): an antimalarial drug from China

  1985cited by this paper
• Studies on the Constituents of Artemisia annua Part II*

  1982cited by this paper
• Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

  1975cited by this paper
• RAPID, SIMULTANEOUS MEASUREMENT OF DNA, PROTEIN, AND CELL VOLUME IN SINGLE CELLS FROM LARGE MAMMALIAN CELL POPULATIONS

  1973cited by this paper
• Reaction of Nitrosyl Chloride with Steroid 5-Enes.1 Nuclear Magnetic Resonance as a Stereochemical Tool in Steroids

  1964cited by this paper

• Azole-Flavonoid Hybrids as Emerging Anticancer Agents: A Bioactivity-Focused Review.

  2026cites this paper
• Synthesis, Characterization, Insecticidal Activity and Antibacterial Evaluation of Some Heterocyclic Compounds Containing 1,2,3-Triazoles Moiety

  2024cites this paper
• Click chemistry and natural products.

  2024cites this paper
• 2,4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Cleistocalyx nervosum var. paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis.

  2023cites this paper
• Dihydroartemisinin-Ursodeoxycholic Bile Acid Hybrids in the Fight against SARS-CoV-2

  2023cites this paper
• Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

  2023cites this paper
• Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target.

  2023cites this paper
• Design, Synthesis, Molecular Docking and Antimicrobial Activities of Novel Triazole-ferulic acid ester Hybrid Carbohydrates

  2022cites this paper
• STUDIES ON SYNTHESES, CRYSTAL STRUCTURES, DFT CALCULATION AND ANTI-BREAST-CANCER ACTIVITIES OF ARTEMINSIN-PURINE HYBRIDS

  2022cites this paper
• A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

  2021cites this paper
• Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications

  2021cites this paper
• 1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

  2021influential citation
• Chalcone Derivatives: Role in Anticancer Therapy

  2021cites this paper
• Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6.

  2021cites this paper
• Six-Membered Rings With 1,2,4-Oxygen or Sulfur Atoms

  2021cites this paper
• A minireview of 1,2,3‐triazole hybrids with O‐heterocycles as leads in medicinal chemistry

  2021influential citation
• Click Chemistry in Natural Product Modification

  2021cites this paper
• Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

  2021cites this paper
• Artemisinin-derived hybrids and their anticancer activity.

  2020cites this paper
• Design, synthesis and anticancer activity of novel pyrimidine and pyrimidine-thiadiazole hybrid glycosides

  2020cites this paper
• Click Synthesis of 1,2,3-Triazole Nucleosides Based on Functionalized Nicotinonitriles

  2020cites this paper
• Design, Synthesis, and Antimicrobial Activities of 1,2,3-Triazole Glycoside Clickamers

  2020cites this paper
• Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase

  2020cites this paper
• Synthesis of New Thiazole and Pyrazole Clubbed 1,2,3-Triazol Derivatives as Potential Antimycobacterial and Antibacterial Agents

  2020cites this paper
• Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure-activity relationship.

  2020cites this paper
• (Iso)Quinoline–Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses

  2020cites this paper
• Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria

  2019cites this paper
• 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.

  2019cites this paper
• Rutin restricts hydrogen peroxide‐induced alterations by up‐regulating the redox‐system: An in vitro, in vivo and in silico study

  2018cites this paper