Btk-dependent Rac activation and actin rearrangement following FcεRI aggregation promotes enhanced chemotactic responses of mast cells

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.071043PMID 20587594PMCID PMC2908047
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TRPM4 regulates migration of mast cells in mice.

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  2008influential reference
• The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells1

  2008influential reference
• Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release.

  2008influential reference
• Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo1

  2008influential reference
• Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.

  2008influential reference
• G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005influential reference
• Mast cells in the development of adaptive immune responses

  2005cited by this paper
• FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

  2005cited by this paper
• IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.

  2005influential reference
• Signalling by PI3K isoforms: insights from gene-targeted mice.

  2005cited by this paper
• Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.

  2005influential reference
• Mast cells

  2004cited by this paper
• Mast-cell responses to pathogens

  2004cited by this paper
• The mastocyte: the "other" inflammatory cell in immunopathogenesis.

  2004cited by this paper
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  1998influential reference
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  1998cited by this paper
• Mast cells.

  1997cited by this paper
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  1996cited by this paper
• Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines.

  1995cited by this paper
• Stem cell factor is a chemotactic factor for human mast cells.

  1994influential reference
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  1992cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1980cited by this paper

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