Small molecule–based reversible reprogramming of cellular lifespan

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature Chemical Biology

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NCHEMBIO800PMID 16767085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Retraction: small molecule-based reversible reprogramming of cellular lifespan.

  2008cited by this paper
• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  2005cited by this paper
• The signals and pathways activating cellular senescence.

  2005cited by this paper
• Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

  2005cited by this paper
• Small molecules: the missing link in the central dogma

  2005cited by this paper
• A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells

  2005cited by this paper
• Nuclear bodies and compartments: functional roles and cellular signalling in health and disease.

  2004cited by this paper
• ATR and ATM regulate the timing of DNA replication origin firing

  2004cited by this paper
• Post-translational modification of p53 in tumorigenesis

  2004cited by this paper
• Exploring biology with small organic molecules

  2004cited by this paper
• Target identification in chemical genetics: the (often) missing link.

  2004cited by this paper
• Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).

  2004cited by this paper
• Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

  2004cited by this paper
• Polycomb CBX7 has a unifying role in cellular lifespan

  2004cited by this paper
• ATM and related protein kinases: safeguarding genome integrity

  2003cited by this paper
• Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.

  2003cited by this paper
• DNA damage foci at dysfunctional telomeres.

  2003cited by this paper
• A DNA damage checkpoint response in telomere-initiated senescence

  2003cited by this paper
• ATM function and telomere stability

  2002cited by this paper
• Protein kinases — the major drug targets of the twenty-first century?

  2002cited by this paper
• Historical claims and current interpretations of replicative aging

  2002cited by this paper
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

  2002cited by this paper
• Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

  2000cited by this paper
• Chemical genetics: exploring and controlling cellular processes with chemical probes.

  1999cited by this paper
• p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

  1999cited by this paper
• TRF2 protects human telomeres from end-to-end fusions.

  1998cited by this paper
• A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts.

  1998cited by this paper
• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper

• Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003–present)

  2024cites this paper
• Synthesis, growth inhibitory activity against tumor cells and structure-activity relationship of CGK733 and its analogs.

  2024cites this paper
• Advances in small molecules in cellular reprogramming: effects, structures, and mechanisms.

  2020cites this paper
• APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression

  2019cites this paper
• Targeting ATM for Cancer Therapy: Prospects for Drugging ATM

  2018cites this paper
• Neuroprotective effect of ATM/ATR inhibitor CGK733 on acrylamide-induced inhibition of cytotoxic effects and neurite outgrowth in PC12 cells

  2018cites this paper
• 세포 노화 저해제를 유효성분으로 함유하는 피부 주름 개선용 및 피부 손상 염증 질환 치료용 조성물

  2016cites this paper
• H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication

  2016cites this paper
• Composition pour atténuer les rides de la peau et pour traiter les maladies inflammatoires endommageant la peau, contenant comme principe actif un inhibiteur de la sénescence cellulaire

  2016cites this paper
• Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy.

  2016cites this paper
• Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition

  2015cites this paper
• Kinase inhibitors with redox and anti-inflammatory activities.

  2015influential citation
• Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.

  2015cites this paper
• High mobility group box protein‐1 promotes cerebral edema after traumatic brain injury via activation of toll‐like receptor 4

  2014cites this paper
• Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

  2014cites this paper
• Chemical strategies for development of ATR inhibitors

  2014cites this paper
• The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway

  2014influential citation
• ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS

  2014cites this paper
• The Heterogenic Final Cell Cycle of Retinal Horizontal Cells

  2014cites this paper
• Manipulation of DNA damage checkpoint signaling in cancer cells by antioxidant biofactor (AOB).

  2013cites this paper
• Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

  2013cites this paper
• MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA Repair

  2013cites this paper
• Molecular imaging of the ATM kinase activity.

  2013influential citation
• CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells.

  2012cites this paper
• Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.

  2012cites this paper
• A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

  2012cites this paper
• Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization.

  2012cites this paper
• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

  2012cites this paper
• MOLECULAR MECHANISMS OF THE DNA DAMAGE RESPONSE INDUCED DURING PARVOVIRUS INFECTION

  2012cites this paper
• Target Identification: A Challenging Step in Forward Chemical Genetics

  2011cites this paper
• PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS

  2011cites this paper
• Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence

  2011cites this paper
• Identification of a checkpoint modulator with synthetic lethality to p53 mutants

  2011cites this paper
• Editorial Expression of Concern

  2011cites this paper
• CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

  2011cites this paper
• Coronavirus Infection Induces DNA Replication Stress Partly through Interaction of Its Nonstructural Protein 13 with the p125 Subunit of DNA Polymerase δ

  2011cites this paper
• Frontiers in targeting glioma stem cells.

  2011cites this paper
• Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1

  2011cites this paper
• ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.

  2010cites this paper
• Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death

  2010influential citation
• High-content analysis of single cells directly assembled on CMOS sensor based on color imaging.

  2010cites this paper
• A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

  2010cites this paper
• The DNA Damage Response Pathway Regulates the Alternative Splicing of the Apoptotic Mediator Bcl-x*

  2010cites this paper
• Phosphorylation of ATM/ATR substrates in eukaryotic cells after infection with Helicobacter pylori

  2010cites this paper
• Cell context-dependent involvement of ATR in early stages of retroviral replication.

  2010cites this paper
• New boryl radicals derived from N-heteroaryl boranes: generation and reactivity.

  2010cites this paper
• The Perinucleolar Compartment Is Directly Associated with DNA*

  2009cites this paper
• DNA-PKcs and ATM co-regulate DNA double-strand break repair.

  2009cites this paper
• The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

  2009cites this paper
• Udu deficiency activates DNA damage checkpoint.

  2009cites this paper
• DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment.

  2009cites this paper
• Targeting the DNA damage response in cancer.

  2009cites this paper
• Forward Chemical Genetics

  2008cites this paper
• Senescence: the good the bad and the dysfunctional.

  2008cites this paper
• Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53

  2008cites this paper
• Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin.

  2008influential citation
• Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.

  2008cites this paper
• Modulation of the DNA-damage response to HZE particles by shielding.

  2008cites this paper
• Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

  2008cites this paper
• Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

  2008influential citation
• Editorial Expression of Concern

  2008cites this paper
• Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling.

  2008cites this paper
• Correcting the scientific record.

  2008cites this paper
• Retraction: small molecule-based reversible reprogramming of cellular lifespan.

  2008cites this paper
• Chronic Treatment with Resveratrol Induces Redox Stress- and Ataxia Telangiectasia-mutated (ATM)-dependent Senescence in p53-positive Cancer Cells*

  2007cites this paper
• Tagged library approach facilitates forward chemical genetics.

  2007cites this paper
• Targeted cancer therapies based on the inhibition of DNA strand break repair

  2007cites this paper
• Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

  2007cites this paper
• Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention

  2007cites this paper
• Cellular senescence: when bad things happen to good cells

  2007cites this paper