Syntheses and applications of enantiopure δ-amino acids and their precursors

Abstract Enantiopure unnatural homologated amino acids, whereby there is > 1 carbon atom between the C- and N- termini have found great utility in a number of applications. The enantiopure syntheses of β-amino acids are well documented, as increasingly are those of γ-amino acids. δ-Amino acids on the other hand are much less well-studied despite reports of their potential utility. This review attempts to summarise strategies that have been adopted towards the enantioselective synthesis of δ-amino acids and their precursors (e.g. nitrile/nitro/azido/ester/alcohol etc) and where appropriate demonstrate their utility. Only systems which are all carbon between the two termini are considered and only those where the shortest route between any given C-termini and any given N-termini is four carbons long (i.e. lysine derivatives are not considered).

• Publication year

  2018

• Venue

  Tetrahedron

• Publication date

  2018-09-01

• Fields of study

  Chemistry

• Identifiers
  DOI 10.1016/J.TET.2018.05.034
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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