Dantrolene protects hippocampal cells from damage induced by TsTX, an alpha-scorpion toxin from Tityus serrulatus.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Toxicon

• Publication date

  2004-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TOXICON.2004.05.018PMID 15246767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dantrolene – A review of its pharmacology, therapeutic use and new developments

  2004cited by this paper
• A microdialysis study of glutamate concentration in the hippocampus of rats after TsTX toxin injection and blockade of toxin effects by glutamate receptor antagonists.

  2003cited by this paper
• Effects of Dantrolene on Extracellular Glutamate Concentration and Neuronal Death in the Rat Hippocampal CA1 Region Subjected to Transient Ischemia

  2002cited by this paper
• Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.

  2001cited by this paper
• Glutamate uptake.

  2001cited by this paper
• Action of 4-aminopyridine on extracellular amino acids in hippocampus and entorhinal cortex: a dual microdialysis and electroencehalographic study in awake rats.

  2000cited by this paper
• Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.

  2000cited by this paper
• Scorpion toxins specific for Na+-channels.

  1999cited by this paper
• Neuroprotective effects of early vs. late administration of dantrolene in experimental status epilepticus.

  1999influential reference
• Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

  1999cited by this paper
• Alpha- and beta-scorpion toxins evoke glutamate release from rat cortical synaptosomes with different effects on [Na+]i and [Ca2+]i.

  1998cited by this paper
• Behavioral, electroencephalographic, and histopathologic effects of a neuropeptide isolated from Tityus serrulatus scorpion venom in rats.

  1998cited by this paper
• Toxins and genes isolated from scorpions of the genus Tityus.

  1997cited by this paper
• Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.

  1997cited by this paper
• Dantrolene Is Cytoprotective in Two Models of Neuronal Cell Death

  1996cited by this paper
• Action of New World scorpion venom and its neurotoxins in secretion.

  1996cited by this paper
• Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello.

  1996cited by this paper
• NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release.

  1995cited by this paper
• Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices.

  1995cited by this paper
• Effects of tityustoxin on central nervous system

  1995cited by this paper
• Induction or protection of limbic seizures in mice by mGluR subtype selective agonists.

  1995cited by this paper
• Neuronal Ca2+ stores: activation and function.

  1995cited by this paper
• Glutamate receptors and the induction of excitotoxic neuronal death.

  1994cited by this paper
• Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction

  1994cited by this paper
• Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists.

  1993cited by this paper
• Excitatory Amino Acid‐Mediated Cytotoxicity and Calcium Homeostasis in Cultured Neurons

  1993cited by this paper
• Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons.

  1992cited by this paper
• Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus

  1989cited by this paper
• Interaction of scorpion toxins with the sodium channel.

  1984cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Two types of scorpion receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel.

  1982cited by this paper
• Cardiovascular and respiratory effects induced by intracerebroventricular injection of scorpion toxin (tityustoxin) in the rat.

  1977cited by this paper

• Dantrolene paradoxically exacerbates short-term brain glucose hypometabolism, hippocampal damage and neuroinflammation induced by status epilepticus in the rat lithium-pilocarpine model.

  2024cites this paper
• Tb1, a Neurotoxin from Tityus bahiensis Scorpion Venom, Induces Epileptic Seizures by Increasing Glutamate Release

  2020cites this paper
• Effects of Brazilian scorpion venoms on the central nervous system

  2018cites this paper
• Intrahippocampal injection of TsTX-I, a beta-scorpion toxin, causes alterations in electroencephalographic recording and behavior in rats.

  2010cites this paper