High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer

Background:This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.Methods:First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT–qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.Results:GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive (pN+) and oestrogen and/or progesterone receptor-negative status. In univariate analysis, high gabarapl1 levels were associated with a lower risk of metastasis in all patients (hazard ratio (HR) 4.96), as well as in pN+ patients (HR 14.96). In multivariate analysis, gabarapl1 expression remained significant in all patients (HR 3.63), as well as in pN+ patients (HR 5.65). In univariate or multivariate analysis, gabarapl1 expression did not disclose any difference in metastasis risk in lymph node-negative patients.Conclusions:Our data show for the first time that the level of gabarapl1 mRNA expression in breast tumours is a good indicator of the risk of recurrence, specifically in pN+ patients.

• Publication year

  2010

• Venue

  British Journal of Cancer

• Publication date

  2010-03-02

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/sj.bjc.6605568PMID 20197771PMCID 2844027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator.

  2008cited by this paper
• Epigenomics and breast cancer.

  2008cited by this paper
• Specific regional distribution of gec1 mRNAs in adult rat central nervous system.

  2008cited by this paper
• Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis.

  2007cited by this paper
• Effect of 7-O-β-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor α transcriptional activity

  2007cited by this paper
• Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity.

  2007cited by this paper
• GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.

  2006cited by this paper
• Characterization of γ-Aminobutyric Acid Type A Receptor–Associated Protein, a Novel Tumor Suppressor, Showing Reduced Expression in Breast Cancer

  2005cited by this paper
• Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.

  2005cited by this paper
• GEC1, a protein related to GABARAP, interacts with tubulin and GABA(A) receptor.

  2004cited by this paper
• GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma.

  2004cited by this paper
• Breast cancer: occurrence, risk factors and hormone metabolism

  2003cited by this paper
• Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system.

  2003cited by this paper
• Mutations in normal breast tissue and breast tumours

  2001cited by this paper
• Adjuvant therapy of primary breast cancer: a review of key findings from the 7th international conference, St. Gallen, February 2001.

  2001cited by this paper
• Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells

  1993cited by this paper
• Revision of the standards for the assessment of hormone receptors in human breast cancer; report of the second E.O.R.T.C. Workshop, held on 16-17 March, 1979, in the Netherlands Cancer Institute.

  1980cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Histological Grading and Prognosis in Breast Cancer

  1957influential reference

• Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma

  2025cites this paper
• Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments

  2025cites this paper
• The LncRNA GABARAPL3/miR-155-5p axis modulates the proliferation and invasion of liver cancer cells by regulating GABARAPL1

  2025cites this paper
• Lysine Acetyltransferase 8: A Target for Natural Compounds in Cancer Therapy

  2025cites this paper
• Differential expression of GABARAPs in glioblastoma renders temozolomide sensitivity in a p53-dependent manner.

  2025cites this paper
• Differential expression of GABARAPs in GBM renders temozolomide sensitivity in a p53-dependent manner

  2024cites this paper
• Gamma-Aminobutyric Acid Type A Receptor Subunit Pi is a potential chemoresistance regulator in colorectal cancer

  2023cites this paper
• GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development.

  2023cites this paper
• Bioinformatics identification of ferroptosis-related genes and therapeutic drugs in rheumatoid arthritis

  2023cites this paper
• A new perspective on the autophagic and non-autophagic functions of the GABARAP protein family: a potential therapeutic target for human diseases

  2023cites this paper
• C1QBP Mediates Breast Cancer Cell Proliferation and Growth via Multiple Potential Signalling Pathways

  2023cites this paper
• Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma

  2022cites this paper
• A Mitophagy-Related Gene Signature for Subtype Identification and Prognosis Prediction of Hepatocellular Carcinoma

  2022cites this paper
• Unlocking the gate to GABARAPL2

  2022influential citation
• An Autophagy-Related Long Non-Coding RNA Prognostic Signature for Patients with Lung Squamous Carcinoma Based on Bioinformatics Analysis

  2021cites this paper
• Immune implication of an autophagy-related prognostic signature in uveal melanoma

  2021cites this paper
• Identification and validation of a novel ferroptosis-related gene model for predicting the prognosis of gastric cancer patients

  2021cites this paper
• An autophagy-related prognostic signature associated with immune microenvironment features of uveal melanoma

  2021cites this paper
• Zebrafish xenografts to isolate unique human breast cancer metastatic cell populations

  2021cites this paper
• GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback

  2021cites this paper
• Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1

  2020cites this paper
• Prognostic Autophagy-Related Genes of Gastric Cancer Patients on Chemotherapy

  2020cites this paper
• Autophagy is associated with a robust specific transcriptional signature in breast cancer subtypes

  2020cites this paper
• Identification and validation of prognostic signature for breast cancer based on genes potentially involved in autophagy

  2020cites this paper
• The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

  2020cites this paper
• Discovery of a novel tumor suppressor from the autophagy regulatory network: LRRK2 in lung adenocarcinoma

  2019cites this paper
• Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells

  2019cites this paper
• GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation

  2019cites this paper
• The Application of Network Structure Aanalysis in the Study of Disease Mechanisms

  2019cites this paper
• miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis-Associated Genes.

  2018cites this paper
• Cell-Based Assays for Evaluation of Autophagy in Cancers

  2018cites this paper
• ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes

  2018cites this paper
• GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

  2017influential citation
• Expression de GALIG, gène inducteur de la mort cellulaire, dans des cellules normales et pathologiques

  2017cites this paper
• GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer

  2017cites this paper
• Characterizing the Deubiquitinase USP 35 by

  2016cites this paper
• GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer

  2016cites this paper
• Gene-expression profiles in lung adenocarcinomas related to chronic wood smoke or tobacco exposure

  2016cites this paper
• Metabolic, autophagic, and mitophagic activities in cancer initiation and progression

  2016cites this paper
• Cross-cancer profiling of molecular alterations within the human autophagy interaction network

  2015cites this paper
• Synthesis, anticancer and molecular docking studies of benzofuran derivatives

  2015cites this paper
• GABARAP is a determinant of apoptosis in growth‐arrested chicken embryo fibroblasts

  2015cites this paper
• The Role of Autophagy in Stress and Cancer

  2015cites this paper
• The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models

  2015cites this paper
• Gabarapl1 mediates androgen-regulated autophagy in prostate cancer

  2015cites this paper
• The Role of Autophagy in Hepatocellular Carcinoma

  2015cites this paper
• Mitophagy mechanisms and role in human diseases.

  2014cites this paper
• The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells

  2014influential citation
• Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma.

  2014cites this paper
• Autophagy and cancer

  2014influential citation
• Synthesis, anticancer, and molecular docking studies of pyranone derivatives

  2013cites this paper
• High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients

  2012cites this paper
• [Towards a better knowledge of breast cancer physiopathology: the proteomics approach].

  2012cites this paper
• Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.

  2012cites this paper
• La protéine Gec1/Gabarapl1 : rôle au cours de l'autophagie et expression dans les cellules cancéreuses

  2011cites this paper
• Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

  2011cites this paper
• GABARAPL1 antibodies: Target one protein, get one free!

  2011cites this paper
• Dual function of ERRα in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.

  2011influential citation
• GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

  2011cites this paper
• GABARAPL1 (GEC1): Original or copycat?

  2011cites this paper