Zinc inhibits Bax and Bak activation and cytochrome c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cell Death and Differentiation

• Publication date

  2003-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.cdd.4401234PMID 12761574
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• The Bcl2 family: regulators of the cellular life-or-death switch

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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal*

  1998cited by this paper
• Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells.

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998influential reference
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Simultaneous release of adenylate kinase and cytochrome c in cell death

  1998cited by this paper
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  1997cited by this paper
• Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

  1997cited by this paper
• Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

  1996cited by this paper
• Assays for DNA fragmentation, endonucleases, and intracellular pH and Ca2+ associated with apoptosis.

  1995cited by this paper
• Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate.

  1993cited by this paper
• Identification of deoxyribonuclease II as an endonuclease involved in apoptosis.

  1993cited by this paper
• Physiological role for zinc in prevention of apoptosis (gene-directed death).

  1991cited by this paper
• Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion.

  1990cited by this paper
• Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.

  1988cited by this paper
• Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

  1984cited by this paper
• Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

  1983cited by this paper
• FEDERAL REPUBLIC OF GERMANY

  1980cited by this paper
• A functional role of polyADPR in DNA synthesis.

  1970cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2021cites this paper
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  2018cites this paper
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  2015cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W)

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