C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Methods in molecular biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-1-4939-7219-7_3PMID 28791633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: An Update.

  2016cited by this paper
• Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling

  2016cited by this paper
• CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering

  2016cited by this paper
• Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

  2016cited by this paper
• Overcoming drug resistance to receptor tyrosine kinase inhibitors: Learning from lung cancer.

  2016cited by this paper
• Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

  2015cited by this paper
• A Transparent window into biology: A primer on Caenorhabditis elegans.

  2015cited by this paper
• Transposon-Assisted Genetic Engineering with Mos1-Mediated Single-Copy Insertion (MosSCI).

  2015cited by this paper
• Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

  2015cited by this paper
• Ligand regulation of a constitutively dimeric EGF receptor

  2015cited by this paper
• High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes

  2015cited by this paper
• A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans

  2014cited by this paper
• The ErbB/HER family of protein-tyrosine kinases and cancer.

  2014cited by this paper
• An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during C. elegans Vulva Induction

  2014cited by this paper
• Immunostaining for markers of apoptosis in the Caenorhabditis elegans germline.

  2014cited by this paper
• An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling

  2014cited by this paper
• A rapid protocol for integrating extrachromosomal arrays with high transmission rate into the C. elegans genome.

  2013cited by this paper
• Robustness and epistasis in the C. elegans vulval signaling network revealed by pathway dosage modulation.

  2013cited by this paper
• Canonical RTK-Ras-ERK signaling and related alternative pathways

  2013cited by this paper
• RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans

  2012cited by this paper
• Single molecule fluorescent in situ hybridization (smFISH) of C. elegans worms and embryos.

  2012cited by this paper
• An In Vivo C. elegans Model System for Screening EGFR-Inhibiting Anti-Cancer Drugs

  2012cited by this paper
• The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

  2011cited by this paper
• OrthoList: A Compendium of C. elegans Genes with Human Orthologs

  2011cited by this paper
• MosSCI and Gateway Compatible Plasmid Toolkit for Constitutive and Inducible Expression of Transgenes in the C. elegans Germline

  2011cited by this paper
• Ras effector switching promotes divergent cell fates in C. elegans vulval patterning.

  2011cited by this paper
• EOR-2 Is an Obligate Binding Partner of the BTB–Zinc Finger Protein EOR-1 in Caenorhabditis elegans

  2010cited by this paper
• Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling.

  2010cited by this paper
• The caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells

  2010cited by this paper
• Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes

  2010cited by this paper
• Lung cancer.

  2008cited by this paper
• Imaging individual mRNA molecules using multiple singly labeled probes

  2008cited by this paper
• Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans

  2007cited by this paper
• Establishment of a tissue-specific RNAi system in C. elegans.

  2007cited by this paper
• Transformation and microinjection

  2006cited by this paper
• Nomarski images for learning the anatomy, with tips for mosaic analysis.

  2006cited by this paper
• Maintenance of C. elegans.

  2006cited by this paper
• Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

  2006cited by this paper
• Finding function in novel targets: C. elegans as a model organism

  2006cited by this paper
• Immunohistochemistry.

  2006cited by this paper
• Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

  2006cited by this paper
• Vulval development.

  2005cited by this paper
• Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.

  2005cited by this paper
• The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.

  2005cited by this paper
• Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization.

  2005cited by this paper
• C. elegans Vulval Development as a Model System to Study the Cancer Biology of EGFR Signaling

  2004cited by this paper
• Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.

  2004cited by this paper
• Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

  2004cited by this paper
• The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.

  2004cited by this paper
• The uric-86 Gene Product Couples Cell Lineage and Cell Identity in C . elegans

  2003cited by this paper
• Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7.

  2003cited by this paper
• Gene expression markers for Caenorhabditis elegans vulval cells.

  2002cited by this paper
• Gene expression markers for Caenorhabditis elegans vulval cells.

  2002cited by this paper
• C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.

  2002cited by this paper
• A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.

  2002cited by this paper
• Creation of low-copy integrated transgenic lines in Caenorhabditis elegans.

  2001cited by this paper
• Untangling the ErbB signalling network

  2001cited by this paper
• Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia

  2001cited by this paper
• A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes.

  2000cited by this paper
• ARK-1 inhibits EGFR signaling in C. elegans.

  2000cited by this paper
• Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.

  1999cited by this paper
• EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans.

  1998cited by this paper
• The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.

  1998cited by this paper
• MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.

  1998cited by this paper
• Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans.

  1998cited by this paper
• Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins.

  1997cited by this paper
• Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.

  1997cited by this paper
• Vulval development in Caenorhabditis elegans.

  1997cited by this paper
• LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction.

  1996cited by this paper
• MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

  1995cited by this paper
• KSR, a novel protein kinase required for RAS signal transduction.

  1995cited by this paper
• Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl

  1995cited by this paper
• The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

  1995cited by this paper
• sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

  1995cited by this paper
• The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.

  1995cited by this paper
• A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

  1994cited by this paper
• unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.

  1994cited by this paper
• The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

  1994cited by this paper
• Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

  1994cited by this paper
• The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.

  1994cited by this paper
• C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

  1993cited by this paper
• C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

  1992cited by this paper
• Muscle cell attachment in Caenorhabditis elegans

  1991cited by this paper
• Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

  1991cited by this paper
• Signal transduction during C. elegans vulval induction.

  1991cited by this paper
• let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein.

  1990cited by this paper
• The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

  1990cited by this paper
• The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

  1990cited by this paper
• The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

  1989cited by this paper
• The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch

  1989cited by this paper
• The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans.

  1989cited by this paper
• Pattern formation during vulval development in C. elegans.

  1986cited by this paper
• lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor.

  1985cited by this paper
• The lin-12 locus specifies cell fates in Caenorhabditis elegans.

  1983cited by this paper
• Egg-laying defective mutants of the nematode Caenorhabditis elegans.

  1983cited by this paper
• Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans.

  1980cited by this paper
• Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.

  1977cited by this paper
• Post-embryonic development in the ventral cord of Caenorhabditis elegans.

  1976cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper

• Centralspindlin is partially required for C. elegans anchor cell specification, vulval induction and morphogenesis.

  2025cites this paper
• ALG-1, a microRNA argonaute, promotes vulva induction in C. elegans

  2024cites this paper
• Centralspindlin promotes C. elegans anchor cell specification, vulva induction and morphogenesis

  2024cites this paper
• A Drug Discovery Pipeline for MAPK/ERK Pathway Inhibitors in Caenorhabditis elegans

  2024cites this paper
• Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva

  2023cites this paper
• SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo.

  2022cites this paper
• Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression

  2022cites this paper
• EGFR signal transduction is downregulated in C. elegans Vulval Precursor Cells during dauer diapause.

  2022cites this paper
• A Floxed exon (Flexon) approach to Cre-mediated conditional gene expression

  2021cites this paper
• Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the Caenorhabditis elegans vulval precursor cells

  2021cites this paper
• LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7

  2020cites this paper
• Negative feedback by conserved kinases patterns the degradation of Caenorhabditis elegans Raf in vulval fate patterning

  2020cites this paper
• A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics

  2020cites this paper
• Dynamic expression and localization of the LIN-2/7/10 protein scaffolding complex during C. elegans vulval development

  2020cites this paper