Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Clinical Investigation

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI46490PMID 22484815PMCID PMC3336971
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current status of the AMOEBA polarizable force field.

  2010cited by this paper
• Light chain-induced acute renal failure can be reversed by bortezomib-doxorubicin-dexamethasone in multiple myeloma: results of a phase II study.

  2010cited by this paper
• Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis.

  2009cited by this paper
• Resolution of cast nephropathy following free light chain removal by haemodialysis in a patient with multiple myeloma: a case report

  2008cited by this paper
• Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly.

  2008cited by this paper
• Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique.

  2008cited by this paper
• Improvement of cast nephropathy with plasma exchange depends on the diagnosis and on reduction of serum free light chains.

  2008cited by this paper
• Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate.

  2007cited by this paper
• DISULFIND: a disulfide bonding state and cysteine connectivity prediction server

  2006cited by this paper
• Potential protective action of pituitary adenylate cyclase-activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury.

  2006cited by this paper
• DiANNA: a web server for disulfide connectivity prediction

  2005cited by this paper
• Theory and applications of computational chemistry : the first forty years

  2005cited by this paper
• Chapter 41 – Advances in electronic structure theory: GAMESS a decade later

  2005cited by this paper
• Theory and Applications of Computational Chemistry The First Forty Years

  2005cited by this paper
• Complete sequencing and characterization of 21,243 full-length human cDNAs

  2004cited by this paper
• AL-amyloidosis is underdiagnosed in renal biopsies.

  2004cited by this paper
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

  2004cited by this paper
• Identification and characterization of D8C, a novel domain present in liver‐specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy

  2004cited by this paper
• Tamm-Horsfall glycoprotein: biology and clinical relevance.

  2003cited by this paper
• Review of 1027 patients with newly diagnosed multiple myeloma.

  2003influential reference
• Polarizable Atomic Multipole Water Model for Molecular Mechanics Simulation

  2003cited by this paper
• The ZP domain is a conserved module for polymerization of extracellular proteins

  2002cited by this paper
• Multiple myeloma and light chain-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival.

  2001cited by this paper
• Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein.

  2001cited by this paper
• Investigation

  2000cited by this paper
• Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells.

  2000cited by this paper
• Cancer statistics, 2000

  2000cited by this paper
• Renal failure in multiple myeloma: reversibility and impact on the prognosis

  2000cited by this paper
• Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats.

  1998cited by this paper
• Frequent N addition and clonal relatedness among immunoglobulin lambda light chains expressed in rheumatoid arthritis synovia and PBL, and the influence of V lambda gene segment utilization on CDR3 length.

  1998cited by this paper
• Renal failure in multiple myeloma: presenting features and predictors of outcome in 94 patients from a single institution.

  1998cited by this paper
• Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

  1998cited by this paper
• Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein.

  1997cited by this paper
• Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

  1995cited by this paper
• Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy.

  1995cited by this paper
• Correlation of two-hybrid affinity data with in vitro measurements

  1995cited by this paper
• Bence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation.

  1993cited by this paper
• Pathobiology of cast nephropathy from human Bence Jones proteins.

  1992cited by this paper
• A rheumatoid factor from a normal individual encoded by VH2 and V kappa II gene segments.

  1992cited by this paper
• A rheumatoid factor from a normal individual encoded by VH2 and VkII gene segments

  1992cited by this paper
• Nephrotoxic potential of Bence Jones proteins.

  1991cited by this paper
• Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition.

  1991cited by this paper
• Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins.

  1990cited by this paper
• Cancer statistics

  1989cited by this paper
• A novel genetic system to detect protein–protein interactions

  1989cited by this paper
• Differential nephrotoxicity of low molecular weight proteins including Bence Jones proteins in the perfused rat nephron in vivo.

  1988cited by this paper
• Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.

  1987cited by this paper
• Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo.

  1987cited by this paper
• Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat.

  1985cited by this paper
• Pathophysiology of acute Bence-Jones protein nephrotoxicity in the rat.

  1981cited by this paper

• FTY-720 pre-treatment attenuates acute lung injury following bilateral renal ischemia/reperfusion but not bilateral nephrectomy.

  2026cites this paper
• Advances in multiple myeloma blood-based monitoring and its clinical applications

  2025cites this paper
• Punarnava (Boerhavia diffusa) Ameliorates Cisplatin Induced Acute Kidney Inflammation by Regulating TLR4 Signaling Pathway in Pre-clinical Mouse Model

  2025cites this paper
• Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report

  2025cites this paper
• Immunoglobulin repertoire sequencing and de novo sequencing - Powerful tools for identifying free light chains from patients with light chain cast nephropathy.

  2024cites this paper
• Management of Renal Failure in Multiple Myeloma

  2023cites this paper
• Crystalline Light Chain Casts and Hypercalcemia Induced Acute Kidney Injury: A Rare Presentation of Multiple Myeloma

  2023cites this paper
• Monoclonal Gammopathy of Renal Significance: A Molecular Middle Earth between Oncology, Nephrology, and Pathology

  2022cites this paper
• Pathophysiology, Prevention, and Nondialytic Treatment of ATN in Hospitalized Patients

  2022cites this paper
• Management of acute kidney injury in symptomatic multiple myeloma.

  2021cites this paper
• Kidney injury and disease in patients with haematological malignancies

  2021cites this paper
• The characteristics of patients with kidney light chain deposition disease concurrent with light chain amyloidosis.

  2021cites this paper
• Cellular Antioxidant Mechanisms Control Immunoglobulin Light Chain-Mediated Proximal Tubule Injury.

  2021cites this paper
• Treatment of Multiple Myeloma with Kidney Involvement

  2021cites this paper
• The Clone Wars: Diagnosing and Treating Dysproteinemic Kidney Disease in the Modern Era

  2021cites this paper
• Renal Expression of Light Chain Binding Proteins

  2021cites this paper
• Preventive strategies for acute kidney injury in cancer patients

  2020cites this paper
• A practical approach to the pathology of renal intratubular casts.

  2020cites this paper
• Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: A multicenter retrospective study.

  2020cites this paper
• Free light chains injure proximal tubule cells through STAT1-HMGB1-TLR axis.

  2020cites this paper
• Light chain proximal tubulopathy with cast nephropathy in monoclonal gammopathy of renal significance

  2020cites this paper
• Multiple Myeloma–Associated Ig Light Chain Crystalline Cast Nephropathy

  2020influential citation
• Demographic and Characteristic Features of Patients with Multiple Myeloma with Renal Involvement

  2020cites this paper
• Paraproteins

  2020cites this paper
• When acute kidney injury in the intensive care unit is not acute tubular necrosis: A case report of κ-light chain crystalline tubulopathy
.

  2019cites this paper
• Advances on Cell Autophagy and Its Potential Regulatory Factors in Renal Ischemia-Reperfusion Injury

  2019cites this paper
• Unusual Presentation of Multiple Myeloma: A Case Series

  2019cites this paper
• Structural analysis of urinary light chains and proteomic analysis of hyaline tubular casts in light chain associated kidney disorders

  2019cites this paper
• Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.

  2019cites this paper
• Myeloma light chain cast nephropathy, a review

  2019cites this paper
• UMOD genetic variations and myeloma cast nephropathy

  2019cites this paper
• Myeloma cast nephropathy: the dusk of high cutoff haemodialysis.

  2019cites this paper
• Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury.

  2019cites this paper
• Significance of urinary albumin excretion in patients with cast nephropathy

  2019cites this paper
• Animal models of monoclonal immunoglobulin-related renal diseases

  2018cites this paper
• Monoclonal Gammopathies and Kidney Disease: Searching for Significance.

  2018cites this paper
• Treatment of multiple myeloma with renal involvement: the nephrologist’s view

  2018cites this paper
• Clonal Expansion and Interrelatedness of Distinct B-Lineage Compartments in Multiple Myeloma Bone Marrow

  2017cites this paper
• Unusual Manifestations of IgM Monoclonal Gammopathies

  2017cites this paper
• [Uromodulin gene polymorphisms in patients with cast nephropathy in multiple myeloma].

  2017cites this paper
• Demystifying the Monoclonal Gammopathies of Renal Significance

  2017cites this paper
• Multiple Myeloma and the Kidney

  2017cites this paper
• Uromodulin: from physiology to rare and complex kidney disorders

  2017cites this paper
• The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease.

  2017cites this paper
• Haploinsufficiency of the Transcription Factor Ets-1 Is Renoprotective in Dahl Salt-Sensitive Rats.

  2017cites this paper
• High-Cutoff Hemodialysis in Myeloma Cast Nephropathy.

  2017cites this paper
• Amyloidosis: A cancer-derived paraproteinemia and kidney involvement.

  2017cites this paper
• Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients.

  2016cites this paper
• Successful treatment of myeloma cast nephropathy using bortezomib-based chemotherapy plus selective plasma exchange

  2016cites this paper
• Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients.

  2016cites this paper
• Current Trends of Renal Impairment in Multiple Myeloma

  2016cites this paper
• Paraprotein-Related Kidney Disease: Kidney Injury from Paraproteins-What Determines the Site of Injury?

  2016cites this paper
• [Multiple Myeloma: from Diagnosis to the Up-to-date Treatment. Topics: IV. Multiple Myeloma with Renal Impairment and Monoclonal Gammopathy of Renal Significance].

  2016cites this paper
• Paraprotein-Related Kidney Disease: Evaluation and Treatment of Myeloma Cast Nephropathy.

  2016cites this paper
• Effectiveness of Haemodiafiltration with Heat Sterilized High-Flux Polyphenylene HF Dialyzer in Reducing Free Light Chains in Patients with Myeloma Cast Nephropathy

  2015cites this paper
• Kidney diseases associated with monoclonal immunoglobulin M-secreting B-cell lymphoproliferative disorders: a case series of 35 patients.

  2015cites this paper
• Maturation finale des lymphocytes B : de la commutation de classe aux conséquences pathologiques de la production d'immunoglobulines anormales

  2015influential citation
• Dysproteinemias and Kidney Disease

  2015cites this paper
• Myeloma-related kidney disease.

  2014influential citation
• Light chain crystalline kidney disease: diagnostic urine microscopy as the "liquid kidney biopsy".

  2014cites this paper
• 26 – Dysproteinemias and Amyloidosis

  2014cites this paper
• Treatment of acute kidney injury with cast nephropathy.

  2014cites this paper
• [Acute kidney injury: progress in diagnosis and treatments. Topics: IV. Pathophysiology and treatments. 6. Acute kidney injury in hematological disorders].

  2014cites this paper
• Thick ascending limb of the loop of Henle.

  2014cites this paper
• Myeloma Cast Nephropathy

  2014cites this paper
• Mesangial cells as amyloid factory: a unique contribution of animal models.

  2014cites this paper
• Molecular Mechanism in Renal Fibrosis – A Review

  2014cites this paper
• [Myelomatous tubulopathy: the hope of a new drug].

  2013cites this paper
• Zalecenia Polskiej Grupy Szpiczakowej dotyczące rozpoznawania i leczenia szpiczaka plazmocytowego oraz innych dyskrazji plazmocytowych na rok 2015

  2013cites this paper
• Tubular injury in multiple myeloma

  2013cites this paper
• Progress in the development of animal models of acute kidney injury and its impact on drug discovery

  2013cites this paper
• Renal involvement in multiple myeloma.

  2012cites this paper
• Clinicopathological correlation and best treatment of renal disease in Multiple Myeloma

  2012cites this paper
• Current approach to diagnosis and management of acute renal failure in myeloma patients.

  2012cites this paper
• Mechanisms of light chain injury along the tubular nephron.

  2012cites this paper
• Treating myeloma cast nephropathy without treating myeloma.

  2012cites this paper
• Myeloma kidney: advances in molecular mechanisms of acute kidney injury open novel therapeutic opportunities.

  2012cites this paper
• Basic research: Inhibitor of FLC–THP binding prevents AKI in myeloma kidney

  2012cites this paper
• NADPH oxidase regulates efficacy of vaccination in aspergillosis.

  2012influential citation
• Predominant renal syndrome Major type of renal lesion acute kidney injury myeloma cast nephropathy acute tubular necrosis iatrogenic effects direct infiltration of renal parenchyma acute tubulo ‐ interstitial nephropathy proteinuria / nephrotic syndrome LCDD amyloidosis rare types of glomerular invo

  year unknowncites this paper