Efficient two-step synthesis of 9-aryl-6-hydroxy-3H-xanthen-3-one fluorophores.

[reaction: see text] A two-step method for the synthesis of 9-aryl-6-hydroxy-3H-xanthen-3-one fluorophores involving condensation of aryl aldehydes and fluororesorcinol is shown to proceed through a triarylmethane intermediate. The condensation is complicated by retro-Friedel-Crafts reactions which can be minimized by controlling the amount of acid. The xanthenone ring system is prepared by a final oxidative cyclization with DDQ.

• Publication year

  2005

• Venue

  Journal of Organic Chemistry

• Publication date

  2005-10-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JO051243IPMID 16238351
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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