Repeated aripiprazole treatment causes dopamine D2 receptor up-regulation and dopamine supersensitivity in young rats

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Psychopharmacology

• Publication date

  2014-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1177/0269881113504016PMID 24045880PMCID PMC5673084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Animal models of CNS disorders.

  2014cited by this paper
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• Guide for the Care and Use of Laboratory Animals (8th edn)

  2012cited by this paper
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  2012influential reference
• Efficacy and safety of aripiprazole in child and adolescent patients

  2012influential reference
• Chronic Treatment With Aripiprazole Prevents Development of Dopamine Supersensitivity and Potentially Supersensitivity Psychosis

  2011influential reference
• The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment

  2011cited by this paper
• Atypical antipsychotic medications in the management of disruptive behaviors in children: safety guidelines and recommendations.

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• Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons.

  2011influential reference
• Aripiprazole in schizophrenia and schizoaffective disorder: A review.

  2010cited by this paper
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  2010influential reference
• Incidence and persistence of tardive dyskinesia and extrapyramidal symptoms in schizophrenia

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  2009influential reference
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  2008influential reference
• Use of antipsychotic drugs among Dutch youths between 1997 and 2005.

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  2008influential reference
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  2005influential reference
• Effects of chronic neuroleptic treatments on nutrient selection, body weight, and body composition in the male rat under dietary self-selection.

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  2002influential reference
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  1997influential reference
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  1990cited by this paper
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  1989cited by this paper
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• Lesions of substantia nigra by kainic acid: effects on apomorphine-induced stereotyped behaviour.

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• Estimation of the Box Correction for Degrees of Freedom from Sample Data in Randomized Block and Split-Plot Designs

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