Vancomycin intermediate Staphylococcus aureus isolated from a tertiary care hospital in Kolkata

With the increasing incidence of methicillin resistant Staphylococcus aureus(MRSA), vancomycin intermediate Staphylococcus aureus (VISA) & Vancomycin resistant Staphylococcus aureus (VRSA) strains are not a rare phenomenon nowadays. The study was conducted to find out the magnitude of vancomycin resistance and antibiotic susceptibility pattern of those isolates in a tertiary care teaching hospital,Kolkata between August 2009 to July 2011. In this cross sectional study, 714 Staphylococcus aureus were isolated and identified conventionally from various clinical specimens collected from different departments of the hospital. Subsequently,the antimicrobial susceptibility test was performed by Kirby Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) guidelines. All the strains found resistant to vancomycin by disc diffusion method were again recruited to E test for confirmation of resistance. Minimum Inhibitory concentration (MIC) of 4 to 8 mg/L and MIC of >16mg/L were considered as VISA and VRSA respectively. Vancomycin resistance was seen in 21 isolates of S. aureus by disc diffusion method. Among them 4 isolates were found to be VISA when confirmed by E test with MIC varying between 4 to 6 mg/L. No VRSA was detected. VISA strains were resistant to almost all the commonly used antibiotics showing sensitivity to linezolid only. Though incidence was not so high but emergence of VISA rang an alarm to the infection control committee of this tertiary care centre of eastern India.

• Publication year

  2013

• Venue

  IOSR Journal of Dental and Medical Sciences

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.9790/0853-0521923
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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