A novel function for the MAP kinase SMA-5 in intestinal tube stability

Florian Geisler,Harald Gerhardus,Katrin Carberry,Wayne Davis,E. Jorgensen,Christine Richardson,O. Bossinger,R. Leube

Published 2016 in Molecular Biology of the Cell

ABSTRACT

In vivo evidence links SMA-5 to the maintenance of the apical domain in the Caenorhabditis elegans intestine. sma-5 mutations induce morphological and biochemical changes of the intermediate filament system, demonstrating the close relationship between posttranslational modification and structural integrity of the evolutionarily conserved intestinal cytoskeleton.

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