Ethanol Extract of Prunella vulgaris var. lilacina Inhibits HMGB1 Release by Induction of Heme Oxygenase‐1 in LPS‐activated RAW 264.7 Cells and CLP‐induced Septic Mice

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Phytotherapy Research

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/ptr.3613PMID 21971692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
• Stimulation of Alpha7 Nicotinic Acetylcholine Receptor by Nicotine Attenuates Inflammatory Response in Macrophages and Improves Survival in Experimental Model of Sepsis Through Heme Oxygenase-1 Induction

  2011influential reference
• The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice.

  2010influential reference
• Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.

  2010cited by this paper
• Ethanol-induced HO-1 and NQO1 Are Differentially Regulated by HIF-1α and Nrf2 to Attenuate Inflammatory Cytokine Expression*

  2010cited by this paper
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  2010influential reference
• HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism1

  2009cited by this paper
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  2009influential reference
• Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris.

  2009cited by this paper
• Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc.

  2009influential reference
• High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

  2009cited by this paper
• Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-β Signaling Pathway1

  2009cited by this paper
• Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells.

  2008cited by this paper
• Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis.

  2008cited by this paper
• Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death.

  2008cited by this paper
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• Effects of Prunella vulgaris on Mast Cell–Mediated Allergic Reaction and Inflammatory Cytokine Production

  2007influential reference
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  2007cited by this paper
• CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2.

  2006cited by this paper
• Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis.

  2006cited by this paper
• Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.

  2006influential reference
• The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.

  2006cited by this paper
• Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide.

  2006cited by this paper
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  2006cited by this paper
• Heme oxygenase-1: from bench to bedside.

  2005cited by this paper
• Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages

  2005cited by this paper
• Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells.

  2005cited by this paper
• High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

  2005cited by this paper
• Nitric oxide production and signaling in inflammation.

  2005cited by this paper
• Reversing established sepsis with antagonists of endogenous high-mobility group box 1

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• Biological activities of Prunella vulgaris extract

  2003cited by this paper
• Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

  2002cited by this paper
• Heme oxygenase-1: the "emerging molecule" has arrived.

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• A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

  2001cited by this paper
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  2001cited by this paper
• Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.

  2000cited by this paper
• Antioxidative and free radical scavenging activities of selected medicinal herbs.

  2000cited by this paper
• Carbon monoxide provides protection against hyperoxic lung injury.

  1999cited by this paper
• HMG-1 as a late mediator of endotoxin lethality in mice.

  1999cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Institute of Laboratory Animal Resources.

  1995cited by this paper
• rapid communication Carbon monoxide provides protection against hyperoxic lung injury

  year unknowncited by this paper

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