Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Pharmacological Reports

• Publication date

  2008-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 18443378
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prodrugs and soft drugs.

  2006cited by this paper
• Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.

  2005cited by this paper
• Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.

  2004cited by this paper
• An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.

  2003cited by this paper
• The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: Biology and therapeutic relevance

  2003cited by this paper
• Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.

  2002cited by this paper
• The role of mitogen-activated protein (MAP) kinase in breast cancer.

  2002cited by this paper
• Cytotoxicity activity of L-proline analogues of anthraquinone-2-carboxylic acid in breast cancer MCF-7 cells.

  2001cited by this paper
• Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells

  2001cited by this paper
• Interaction between cells and extracellular matrix: signaling by integrins and the elastin-laminin receptor.

  2000cited by this paper
• Prolidase-activated prodrug for cancer chemotherapy cytotoxic activity of proline analogue of chlorambucil in breast cancer MCF-7 cells.

  2000cited by this paper
• Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation.

  2000cited by this paper
• Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells.

  1999cited by this paper
• Prolidase in human breast cancer MCF-7 cells.

  1998cited by this paper
• Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.

  1998cited by this paper
• The IGF-I receptor in cell growth, transformation and apoptosis.

  1997cited by this paper
• Fibroblast chemotaxis and prolidase activity modulation by insulin-like growth factor II and mannose 6-phosphate

  1997cited by this paper
• Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors

  1997cited by this paper
• Cooperation between soluble factors and integrin‐mediated cell anchorage in the control of cell growth and differentiation

  1996cited by this paper
• Inhibition of prolidase activity by non-steroid antiinflammatory drugs in cultured human skin fibroblasts.

  1996cited by this paper
• Modulation of prolidase activity during in vitro aging of human skin fibroblasts the role of extracellular matrix collagen.

  1996cited by this paper
• The MAPK signaling cascade

  1995cited by this paper
• Molecular and cellular aspects of the insulin-like growth factor I receptor.

  1995cited by this paper
• Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix

  1995cited by this paper
• Hydrolysis of proline dipeptides completely fulfills the proline requirement in a proline-auxotrophic Chinese hamster ovary cell line.

  1993cited by this paper
• Proline-dependent structural and biological properties of peptides and proteins.

  1993cited by this paper
• Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

  1992cited by this paper
• Elevated activity of low molecular weight insulin-like growth factor-binding proteins in sera of vitamin C-deficient and fasted guinea pigs.

  1991cited by this paper
• Control of growth and differentiation of vascular cells by extracellular matrix proteins.

  1991cited by this paper
• Scorbutic and fasted guinea pig sera contain an insulin-like growth factor I-reversible inhibitor of proteoglycan and collagen synthesis in chick embryo chondrocytes and adult human skin fibroblasts.

  1990cited by this paper
• Specificity and pH dependence for acylproline cleavage by prolidase.

  1990cited by this paper
• Primary structure and gene localization of human prolidase.

  1989cited by this paper
• Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts.

  1989cited by this paper
• Collagen biosynthesis anomalies in prolidase deficiency: effect of glycyl-L-proline on the degradation of newly synthesized collagen.

  1989cited by this paper
• Inhibition and active-site modelling of prolidase.

  1989cited by this paper
• Metabolism and reactions of alkylating agents.

  1987cited by this paper
• Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

  1987influential reference
• Changes in prolinase and prolidase activity during CCl4 administration inducing liver cytolysis and fibrosis in rat.

  1987cited by this paper
• Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II

  1984cited by this paper
• Prolidase and prolidase deficiency.

  1984cited by this paper
• Optimal conditions for prolidase assay by proline colorimetric determination: application to iminodipeptiduria.

  1982cited by this paper
• How does the extracellular matrix direct gene expression?

  1982cited by this paper
• Synthesis of Potentially Antineoplastic Derivatives of N‐[N‐(2‐Chloroethyl)‐N‐nitrosocarbamoyl]amino Acids

  1981cited by this paper
• Cell surface proteins and malignant transformation.

  1976cited by this paper
• Clinical comparison of the nitrosoureas

  1975cited by this paper
• Iminodipeptiduria: a genetic defect in recycling collagen; a method for determining prolidase in erythrocytes.

  1975cited by this paper
• 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.

  1972cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• A syndrome resembling lathyrism associated with iminodipeptiduria.

  1968cited by this paper
• Photometric estimation of proline and ornithine.

  1952cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Targeting prolidase. A survey of the literature data to depict a structure-activity relationship frame and to address future studies for drug development.

  2024cites this paper
• Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism

  2020cites this paper
• MAJOR BIOACTIVE TRITERPENOIDS FROM GANODERMA SPECIES AND THEIR THERAPEUTIC ACTIVITY: A REVIEW

  2019cites this paper
• Metabolic Activation and Drug Targeting

  2016cites this paper
• From 2000years of Ganoderma lucidum to recent developments in nutraceuticals.

  2015cites this paper
• Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways

  2013cites this paper
• Anticancer prodrugs: an overview of major strategies and recent developments.

  2011cites this paper
• Synthesis and cytotoxic activity of G3 PAMAM-NH_2 dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells

  2010cites this paper
• Comparison of influence of carmustine and new proline analog of nitrosourea on antioxidant system in breast carcinoma cells (MCF-7)

  2010influential citation
• Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells.

  2010cites this paper
• Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells

  2010cites this paper
• Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression

  2010cites this paper
• Proline Analogue of Nitrosourea as a New Cytotoxic Prodrug

  2009cites this paper