Accelerated breakdown of immunological tolerance following whole body irradiation.

Rats were made unresponsive to mouse erythrocytes or bovine serum albumin by a series of injections starting at birth. The unresponsiveness, though not always complete, remained constant in a given animal if antigen injections were continued. In animals irradiated with 550 or 600 r the tolerance usually broke down, with the formation of substantial amounts of antibody. Normal animals also irradiated at a similar age and given repeated injections of mouse erythrocytes formed excess antibody during the 5th to the 13th postirradiation week. By contrast, irradiated rats receiving a single injection of bovine serum albumin in Freund's adjuvant formed less antibody than did nonirradiated controls. The theoretical implications of the work are discussed.

• Publication year

  1962

• Venue

  Journal of Immunology

• Publication date

  1962-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.88.5.613PMID 14468685
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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