Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cancer Research

• Publication date

  1998-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9731497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential Ganciclovir-Mediated Cytotoxicity and Bystander Killing in Human Colon Carcinoma Cell Lines Expressing Herpes Simplex Virus Thymidine Kinase

  1998cited by this paper
• Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.

  1997cited by this paper
• Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.

  1997cited by this paper
• Gene therapy for cancer: what have we done and where are we going?

  1997cited by this paper
• Improved method to prepare RNA-free DNA from mammalian cells.

  1997cited by this paper
• Mechanism of ‘bystander effect’ killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment

  1997cited by this paper
• Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect.

  1997cited by this paper
• Enzymes and Reactions at the Eukaryotic DNA Replication Fork*

  1997cited by this paper
• Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues.

  1996cited by this paper
• In situ use of suicide genes for cancer therapy.

  1996cited by this paper
• Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

  1996cited by this paper
• In vivo analysis of the 'bystander effect': a cytokine cascade.

  1996cited by this paper
• Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

  1996cited by this paper
• Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.

  1996cited by this paper
• The “Bystander Effect”: Association of U-87 Cell Death with Ganciclovir-Mediated Apoptosis of Nearby Cells and Lack of Effect in Athymic Mice

  1995cited by this paper
• Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir.

  1995cited by this paper
• Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.

  1995cited by this paper
• The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

  1995cited by this paper
• Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.

  1995cited by this paper
• 'Bystander killing' induces apoptosis and is inhibited by forskolin.

  1995cited by this paper
• Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

  1994cited by this paper
• Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.

  1994cited by this paper
• Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

  1994cited by this paper
• Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells.

  1994cited by this paper
• Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

  1993cited by this paper
• Lack of Correlation between the Gap Junctional Communication Capacity of Human Colon Cancer Cell Lines and Expression of the DCC Gene, a Homologue of a Cell Adhesion Molecule (N‐CAM)

  1993cited by this paper
• In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

  1993cited by this paper
• In Vitro Evidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSV tk Retroviral Gene Therapy

  1993cited by this paper
• An experimental model of retrovirus gene therapy for malignant brain tumors.

  1993cited by this paper
• Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.

  1993cited by this paper
• The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

  1993cited by this paper
• Decrease in TTP pools mediated by 5-bromo-2'-deoxyuridine exposure in a human glioblastoma cell line.

  1992cited by this paper
• In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.

  1992cited by this paper
• Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.

  1991cited by this paper
• Metabolism and action of purine nucleoside analogs.

  1991cited by this paper
• Rationales for a pharmacologically optimized treatment of acute nonlymphocytic leukemia with cytosine arabinoside.

  1990cited by this paper
• Lymphoma Regression Induced by Ganciclovir in Mice Bearing a Herpes Thymidine Kinase Transgene

  1990cited by this paper
• Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate.

  1989cited by this paper
• Herpes simplex virus type 1 and human DNA polymerase interactions with 2'-deoxyguanosine 5'-triphosphate analogues. Kinetics of incorporation into DNA and induction of inhibition.

  1989cited by this paper
• Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

  1988cited by this paper
• Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information

  1987cited by this paper
• Saturation of ara-CTP accumulation during high-dose ara-C therapy: pharmacologic rationale for intermediate-dose ara-C.

  1987cited by this paper
• Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapy.

  1987cited by this paper
• Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

  1986cited by this paper
• Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells.

  1985cited by this paper
• Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U

  1984cited by this paper
• Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities.

  1981cited by this paper
• Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information.

  1980cited by this paper
• Correlation of cytotoxicity with incorporation of ara-C into DNA.

  1980cited by this paper
• Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy.

  1979cited by this paper
• Inhibitory effect of 1-beta-D-arabinofuranosylthymine 5'-triphosphate and 1-beta-D-arabinofuranosylcytosine 5'-triphosphate on DNA polymerases from murine cells and oncornavirus.

  1978cited by this paper
• Antiviral Activity of Arabinosylthymine in Herpesviral Replication: Mechanism of Action In Vivo and In Vitro

  1977cited by this paper

• Mechanistic insights into the inhibition of drug‐resistant cytomegalovirus by letermovir and ganciclovir

  2025cites this paper
• NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

  2021cites this paper
• Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

  2020cites this paper
• Senescence in the pathogenesis of age-related macular degeneration

  2020cites this paper
• Biosynthesis and half-life of MBX-2168-triphosphate in herpes virus-infected cells.

  2020cites this paper
• Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1

  2019cites this paper
• Interplay Between the Helicase-Primase and the Dna Polymerase-Processivity Factor During Herpes Dna Replication

  2017cites this paper
• Thalidomide , and Pomalidomide Reactivate the Epstein-Barr Virus Lytic Cycle Through Phosphoinositide 3-kinase Signaling and Ikaros Expression Running title : Immunomodulatory drugs reactivate lytic EBV

  2016cites this paper
• Spatiotemporal PFQNM visualization of the effect of suicide dendriplexes on dividing HeLa cells.

  2016cites this paper
• Therapeutic potential of mesenchymal stem cells in gastrointestinal cancers – current evidence

  2016cites this paper
• Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein–Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression

  2016cites this paper
• Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation

  2015cites this paper
• Improving Adenovirus Efficacy with p14 Fusion Associated Small Transmembrane Protein Expression for Cancer Treatment

  2015cites this paper
• Peptide prodrugs for the treatment of CNS disorders: a perspective for new drugs.

  2014cites this paper
• A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing.

  2014cites this paper
• Regulation and function of adult neurogenesis: from genes to cognition.

  2014cites this paper
• Telomerase activated thymidine analogue pro-drug is a new molecule targeting hepatocellular carcinoma

  2014cites this paper
• The DNA helicase–primase complex as a target for herpes viral infection

  2013cites this paper
• Mitochondrial DNA damage induces apoptosis in senescent cells

  2013cites this paper
• Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells

  2013cites this paper
• Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.

  2013cites this paper
• Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models

  2012cites this paper
• Cytotoxicity of Ganciclovir on Cultured Human Corneal Endothelial Cells

  2012cites this paper
• Effective combination gene therapy using CEACAM6-shRNA and the fusion suicide gene yCDglyTK for pancreatic carcinoma in vitro

  2012cites this paper
• Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells

  2012cites this paper
• Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice.

  2011cites this paper
• Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir

  2011cites this paper
• Addition of a Single E2 Binding Site to the Human Papillomavirus (HPV) Type 16 Long Control Region Enhances Killing of HPV Positive Cells via HPV E2 Protein-Regulated Herpes Simplex Virus Type 1 Thymidine Kinase-Mediated Suicide Gene Therapy

  2010influential citation
• The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production

  2010cites this paper
• The Molecular Basis of Lytic Induction Therapy in Relation to Gamma herpesvirus (KSHV, EBV)-Associated, AIDS-Related Tumors

  2010cites this paper
• Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity.

  2010cites this paper
• Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells.

  2010cites this paper
• MLH1 Deficiency Enhances Tumor Cell Sensitivity to Ganciclovir

  2009cites this paper
• Potential adenovirus-mediated gene therapy of glioma cancer

  2009cites this paper
• Cancer induction by restriction of oncogene expression to the stem cell compartment This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensed

  2009cites this paper
• Cancer induction by restriction of oncogene expression to the stem cell compartment

  2008cites this paper
• A versatile prion replication assay in organotypic brain slices

  2008cites this paper
• Caractérisation de la principale cible thérapeutique du cytomégalovirus humain l'ADN polymérase UL54

  2008cites this paper
• The Role of DNA Damage and Repair in Ganciclovir-mediated Cytotoxicity.

  2008cites this paper
• Membrane-localized activation of glucuronide prodrugs by β-glucuronidase enzymes

  2007cites this paper
• Membrane-localized activation of glucuronide prodrugs by beta-glucuronidase enzymes.

  2007cites this paper
• Mouse models to elucidate the functional roles of adenosine-to-inosine editing.

  2007cites this paper
• Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thymidine kinase-expressing and nonexpressing HeLa cells incubated with ganciclovir.

  2006cites this paper
• Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases

  2006cites this paper
• Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles.

  2006cites this paper
• The Effect of a Methyl or 2-fluoroethyl Substituent at the N-3 Position of Thymidine, 3′-fluoro-3′-deoxythymi-dine and 1-β-D-arabinosylthymine on Their Antiviral and Cytostatic Activity in Cell Culture

  2006cites this paper
• A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.

  2006cites this paper
• Functional Divergence of Kaposi's Sarcoma-Associated Herpesvirus and Related Gamma-2 Herpesvirus Thymidine Kinases: Novel Cytoplasmic Phosphoproteins That Alter Cellular Morphology and Disrupt Adhesion

  2005cites this paper
• In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine.

  2005cites this paper
• GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity

  2005cites this paper
• Introduction to the background, principles, and state of the art in suicide gene therapy

  2005cites this paper
• Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells

  2005cites this paper
• Mise au point d'un système de thérapie génique utilisant le gène HSV-TK couplé au promoteur muté de l'alpha-foetoprotéine dans un vecteur adénoviral

  2005cites this paper
• Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.

  2005cites this paper
• Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.

  2004cites this paper
• HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells.

  2004cites this paper
• Comparison of different methods to assess the cytotoxic effects of cytosine deaminase and thymidine kinase gene therapy

  2004cites this paper
• Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir

  2003cites this paper
• Treatment of Human Papillomavirus (HPV) Type 16-Infected Cells Using Herpes Simplex Virus Type 1 Thymidine Kinase-Mediated Gene Therapy Transcriptionally Regulated by the HPV E2 Protein

  2003cites this paper
• Selective Ablation of Human Embryonic Stem Cells Expressing a “Suicide” Gene

  2003cites this paper
• Suicide Gene Therapy

  2003cites this paper
• Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)

  2003cites this paper
• Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.

  2003cites this paper
• Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer

  2003cites this paper
• Multi-Log Cytotoxicity of Carbocyclic 2′-Deoxyguanosine in HSV-TK-Expressing Human Tumor Cells

  2002influential citation
• Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.

  2002cites this paper
• Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation

  2002cites this paper
• Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.

  2002cites this paper
• A role for MAP kinase in the antitumor activity of a nucleoside analog

  2002cites this paper
• Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy

  2002cites this paper
• Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.

  2002cites this paper
• Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation

  2002cites this paper
• Gene Therapy for Malignant Mesothelioma

  2002cites this paper
• CHAPTER 32 – Treatment of Mesothelioma Using Adenoviral-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Gene in Combination with Ganciclovir

  2002cites this paper
• CHAPTER 8 – GENE-DIRECTED ENZYME PRODRUG THERAPY

  2002cites this paper
• Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.

  2001cites this paper
• against Ganciclovir-induced Cytotoxicity and DNA Breakage Mediates Protection of Mammalian Cells β DNA Polymerase Updated

  2001cites this paper
• Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.

  2001cites this paper
• Genetic risks of antiviral nucleoside analogues--a survey.

  2001cites this paper
• Prodrug-activating systems in suicide gene therapy.

  2000cites this paper
• Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene

  2000influential citation
• Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.

  2000cites this paper
• Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.

  2000cites this paper
• Human Herpesvirus 8 Open Reading Frame 21 Is a Thymidine and Thymidylate Kinase of Narrow Substrate Specificity That Efficiently Phosphorylates Zidovudine but Not Ganciclovir

  2000cites this paper
• Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.

  2000cites this paper
• Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir.

  2000cites this paper
• Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approaches

  2000cites this paper
• Two-drug combinations that increase apoptosis and modulate Bak and Bcl-XL expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase

  2000cites this paper
• Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line.

  2000cites this paper
• Differential Ganciclovir-mediated Cell Killing by Glutamine 125 Mutants of Herpes Simplex Virus Type 1 Thymidine Kinase*

  1999cites this paper
• Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells.

  1999cites this paper
• Gene therapy for malignant pleural mesothelioma.

  1998cites this paper
• Gene-directed enzyme prodrug therapy.

  1998cites this paper