Biphasic effect of iron on human intestinal Caco-2 cells: early effect on tight junction permeability with delayed onset of oxidative cytotoxic damage.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cellular and Molecular Biology

• Publication date

  2003-02-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  PMID 12839340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intestinal Cell Culture Models: Applications in Toxicology and Pharmacology

  2004cited by this paper
• Iron toxicity and antioxidant nutrients.

  2002cited by this paper
• Free radicals, antioxidants, and nutrition.

  2002cited by this paper
• Iron and copper alter tight junction permeability in human intestinal Caco-2 cells by distinct mechanisms.

  2002cited by this paper
• Molecular structure of tight junctions and their role in epithelial transport.

  2001cited by this paper
• Perspectives on nutritional iron deficiency.

  2001cited by this paper
• OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability.

  2001cited by this paper
• Oxidant stress and endothelial cell dysfunction.

  2001cited by this paper
• Iron needs during pregnancy: do we need to rethink our targets?

  2000cited by this paper
• Pharmacokinetics of Orally Administered Camptothecins

  2000cited by this paper
• Both iron deficiency and daily iron supplements increase lipid peroxidation in rats.

  2000cited by this paper
• Iron absorption and transport—An update

  2000cited by this paper
• Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells.

  2000cited by this paper
• Glutathione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer.

  2000cited by this paper
• Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins.

  2000cited by this paper
• Oxidant-induced intestinal barrier disruption and its prevention by growth factors in a human colonic cell line: role of the microtubule cytoskeleton.

  2000cited by this paper
• The effect of copper on tight junctional permeability in a human intestinal cell line (Caco-2).

  1999cited by this paper
• Metabolism of furazolidone: alternative pathways and modes of toxicity in different cell lines.

  1999cited by this paper
• Effects of cadmium chloride on the paracellular barrier function of intestinal epithelial cell lines.

  1999cited by this paper
• Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells.

  1998cited by this paper
• Characterization of furazolidone apical-related effects to human polarized intestinal cells.

  1998cited by this paper
• Intestinal Epithelial Barrier Dysfunction in Crohn's Disease

  1997cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model.

  1997cited by this paper
• The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells

  1997cited by this paper
• Heavy metal toxicity following apical and basolateral exposure in the human intestinal cell line Caco-2.

  1996cited by this paper
• Reactive oxygen species and programmed cell death.

  1996cited by this paper
• Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function.

  1995cited by this paper
• Bathophenanthrolene disulfonic acid and sodium dithionite effectively remove surface-bound iron from Caco-2 cell monolayers.

  1995cited by this paper
• The transport of lysine across monolayers of human cultured intestinal cells (Caco-2) depends on Na(+)-dependent and Na(+)-independent mechanisms on different plasma membrane domains.

  1995cited by this paper
• High-performance liquid chromatography-based thiobarbituric acid tests.

  1994cited by this paper
• D-cycloserine uses an active transport mechanism in the human intestinal cell line Caco 2

  1994cited by this paper
• Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents

  1992cited by this paper
• Direct and indirect actions of HgCl2 and methyl mercury chloride on permeability and chloride secretion across the rat colonic mucosa.

  1992cited by this paper
• Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine.

  1992cited by this paper
• Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct.

  1989cited by this paper
• One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

  1977cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables

  2025cites this paper
• Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology

  2024cites this paper
• Self-assembled low molecular weight chitosan-bilobalide microsuspension protects hippocampal toxicity in amyloid beta(25–35) induced mice

  2024cites this paper
• Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential.

  2023cites this paper
• The Molecular Mechanisms of Ferroptosis and Its Role in Blood-Brain Barrier Dysfunction

  2022cites this paper
• Fecal Iron Measurement in Studies of the Human Intestinal Microbiome

  2022cites this paper
• The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review

  2022cites this paper
• Investigation of the intestinal trans-epithelial transport and antioxidant activity of two hempseed peptides WVSPLAGRT (H2) and IGFLIIWV (H3).

  2021cites this paper
• Chitosan-oleic acid-sodium alginate a hybrid nanocarrier as an efficient delivery system for enhancement of lutein stability and bioavailability.

  2020cites this paper
• The Effects of Iron Supplementation and Fortification on the Gut Microbiota: A Review

  2020cites this paper
• Enhancement of D-chiro-inositol transport across intestinal cells by alpha-Lactalbumin peptides.

  2020cites this paper
• Mycotoxins: Biotransformation and Bioavailability Assessment Using Caco-2 Cell Monolayer

  2020cites this paper
• In Silico and In Vitro Studies of Mycotoxins and Their Cocktails; Their Toxicity and Its Mitigation by Silibinin Pre-Treatment

  2020cites this paper
• Guts, Germs, and Iron: A Systematic Review on Iron Supplementation, Iron Fortification, and Diarrhea in Children Aged 4–59 Months

  2019cites this paper
• Ex Vivo and in Vivo Study of Sucrosomial® Iron Intestinal Absorption and Bioavailability

  2018cites this paper
• H2Oh No! The importance of reporting your water source in your in vivo microbiome studies

  2018cites this paper
• Iron Treatment May Be Difficult in Inflammatory Diseases: Inflammatory Bowel Disease as a Paradigm

  2018cites this paper
• Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell

  2018cites this paper
• Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line.

  2017cites this paper
• Bioaccesibility of Cylindrospermopsin from cooked fish muscle after the application of an in vitro digestion model and its bioavailability.

  2017cites this paper
• Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD

  2017cites this paper
• Nutraceutical Improvement Increases the Protective Activity of Broccoli Sprout Juice in a Human Intestinal Cell Model of Gut Inflammation

  2016cites this paper
• A multidisciplinary investigation on the bioavailability and activity of peptides from lupin protein

  2016cites this paper
• Iron Fortification of Foods for Infants and Children in Low-Income Countries: Effects on the Gut Microbiome, Gut Inflammation, and Diarrhea

  2016cites this paper
• Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells

  2016cites this paper
• Effect of anti-gliadin IgY antibody on epithelial intestinal integrity and inflammatory response induced by gliadin

  2015cites this paper
• Nutritional iron turned inside out: intestinal stress from a gut microbial perspective.

  2014cites this paper
• Responses of the gut microbiota to supplementary iron: a survey at the host-microbial interface

  2014cites this paper
• Serum-reduced and serum-free media for differentiation of Caco-2 cells.

  2013cites this paper
• The Effect of Post-Treatment N-Acetylcysteine in LPS-Induced Acute Lung Injury of Rats

  2012cites this paper
• Iron Availability Increases the Pathogenic Potential of Salmonella Typhimurium and Other Enteric Pathogens at the Intestinal Epithelial Interface

  2012cites this paper
• Good Caco-2 cell culture practices.

  2012cites this paper
• The effects of micronutrient-fortified complementary/replacement food on intestinal permeability and systemic markers of inflammation among maternally HIV-exposed and unexposed Zambian infants.

  2012cites this paper
• Cell growing density affects the structural and functional properties of Caco‐2 differentiated monolayer

  2011cites this paper
• Intestinal oxidative state can alter nutrient and drug bioavailability

  2009cites this paper
• Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells.

  2009cites this paper
• Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia.

  2006cites this paper
• Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses.

  2005cites this paper
• Metal chelates of 2-hydroxy-4-methylthiobutanoic acid in animal feeding. Part 2: Further characterizations, in vitro and in vivo investigations.

  2005cites this paper
• Alteration of Tight and Adherens Junctions on 50-Hz Magnetic Field Exposure in Madin Darby Canine Kidney (MDCK) Cells

  2004cites this paper