LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster

In animals, male fertility requires the successful development of motile sperm. During Drosophila melanogaster spermatogenesis, 64 interconnected spermatids descended from a single germline stem cell are resolved into motile sperm in a process termed individualization. Here we identify a putative double-stranded RNA binding protein LUMP that is required for male fertility. lump1 mutants are male-sterile and lack motile sperm due to defects in sperm individualization. We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation.

• Publication year

  2011

• Venue

  PLoS ONE

• Publication date

  2011-08-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pone.0024151PMID 21912621PMCID 3166160
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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