Long-term α1B-adrenergic receptor activation shortens lifespan, while α1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer incidence

No abstract is available for this paper.

• Publication year

  2014

• Venue

  AGE

• Publication date

  2014-07-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11357-014-9675-7PMID 24994537PMCID PMC4150908
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• α1A-Adrenergic Receptors Regulate Cardiac Hypertrophy In Vivo Through Interleukin-6 Secretion

  2013cited by this paper
• Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes

  2013cited by this paper
• The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure

  2013cited by this paper
• A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis

  2013cited by this paper
• Common genetic variants of the β2‐adrenergic receptor affect its translational efficiency and are associated with human longevity

  2012cited by this paper
• Age-Related Impairment in Insulin Release The Essential Role of b 2-Adrenergic Receptor

  2012cited by this paper
• Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions

  2012cited by this paper
• Age-Related Impairment in Insulin Release

  2012cited by this paper
• Long-Term α1A-Adrenergic Receptor Stimulation Improves Synaptic Plasticity, Cognitive Function, Mood, and Longevity

  2011cited by this paper
• Mammalian models of extended healthy lifespan

  2011cited by this paper
• Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes

  2011cited by this paper
• Identification of markers for imminent death in mice used in longevity and aging research.

  2010cited by this paper
• Sexual dimorphism in stress-induced changes in adrenergic and muscarinic receptor densities in the lung of wild type and corticotropin-releasing hormone-knockout mice

  2010cited by this paper
• α1-Adrenergic Receptors Regulate Neurogenesis and Gliogenesis

  2009cited by this paper
• alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.

  2009cited by this paper
• Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

  2009cited by this paper
• Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

  2009cited by this paper
• Naftopidil, a selective α‐1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest

  2008cited by this paper
• Design of aging intervention studies: the NIA interventions testing program

  2008cited by this paper
• Dominance of the alpha1B-adrenergic receptor and its subcellular localization in human and TRAMP prostate cancer cell lines.

  2007cited by this paper
• Dominance of the α1B-Adrenergic Receptor and its Subcellular Localization in Human and TRAMP Prostate Cancer Cell Lines

  2007cited by this paper
• RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.

  2006cited by this paper
• Causes of death in multiple system atrophy

  2006cited by this paper
• Novel α1-Adrenergic Receptor Signaling Pathways: Secreted Factors and Interactions with the Extracellular Matrix

  2006cited by this paper
• p63 deficiency activates a program of cellular senescence and leads to accelerated aging.

  2005cited by this paper
• Overview of caloric restriction and ageing.

  2005cited by this paper
• α1A- but not α1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism

  2005cited by this paper
• Housing density does not influence the longevity effect of calorie restriction.

  2005cited by this paper
• alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism.

  2005cited by this paper
• Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.

  2004cited by this paper
• Activation of α1A-adrenergic receptor promotes differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype

  2004cited by this paper
• Differential Regulation of the Cell Cycle by α1-Adrenergic Receptor Subtypes

  2004cited by this paper
• Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.

  2004cited by this paper
• Genetically altered mouse models: the good, the bad, and the ugly.

  2003cited by this paper
• α1-Adrenergic Receptor Subtypes Differentially Control the Cell Cycle of Transfected CHO Cells through a cAMP-dependent Mechanism Involving p27 Kip1 *

  2003cited by this paper
• Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.

  2003cited by this paper
• Gene expression profile of neurodegeneration induced by alpha1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis.

  2003cited by this paper
• Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

  2003cited by this paper
• Mice expressing the α1B‐adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation

  2002cited by this paper
• Premature Aging in Mice Deficient in DNA Repair and Transcription

  2002cited by this paper
• Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor*

  2001cited by this paper
• Alpha1‐adrenoceptors (α1‐AR) and vascular smooth muscle cell growth

  2000cited by this paper
• Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy

  2000cited by this paper
• Alpha 1-adrenergic receptor regulation: basic science and clinical implications.

  2000cited by this paper
• α1-Adrenergic receptor regulation: basic science and clinical implications

  2000cited by this paper
• Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy.

  2000cited by this paper
• Contrasting signaling pathways of alpha1A- and alpha1B-adrenergic receptor subtype activation of phosphatidylinositol 3-kinase and Ras in transfected NIH3T3 cells.

  1999cited by this paper
• Contrasting Signaling Pathways of α1A- and α1B-Adrenergic Receptor Subtype Activation of Phosphatidylinositol 3-Kinase and Ras in Transfected NIH3T3 Cells

  1999cited by this paper
• Longevity, stress response, and cancer in aging telomerase-deficient mice.

  1999cited by this paper
• Dwarf mice and the ageing process

  1996cited by this paper
• Adrenergic Receptors Activate Phosphatidylinositol 3-Kinase in Human Vascular Smooth Muscle Cells

  1996cited by this paper
• Alpha 1 adrenergic receptor-induced c-fos gene expression in rat aorta and cultured vascular smooth muscle cells.

  1994cited by this paper
• Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

  1994cited by this paper
• Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748

  1993cited by this paper
• Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748.

  1993cited by this paper
• Effects on ingestive behavior in rats of the alpha 1-adrenoceptor agonist cirazoline.

  1992cited by this paper
• Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline

  1992cited by this paper
• G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

  1991cited by this paper
• Slower growth of tumours in sympathetically denervated murine skin.

  1991cited by this paper
• Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome).

  1989cited by this paper
• Cultured Vascular Smooth Muscle Cells

  1986cited by this paper
• Pathology

  1911cited by this paper

• Drivers of systemic male-female allele frequency divergence in humans

  2026cites this paper
• Adrenoceptors in GtoPdb v.2025.3

  2025cites this paper
• α1A-Adrenergic Receptor as a Target for Neurocognition: Cautionary Tale from Nicergoline and Quinazoline Non-Selective Blockers

  2025cites this paper
• Further In Vitro and Ex Vivo Pharmacological and Kinetic Characterizations of CCF219B: A Positive Allosteric Modulator of the α1A-Adrenergic Receptor

  2025cites this paper
• Jiajian Shuyu pills effectively ameliorate cognitive impairment via regulating the inflammation of microglia in an Alzheimer's disease mouse model.

  2025cites this paper
• Association Between Alpha-1 Adrenoreceptor Antagonist Use and Cognitive Impairment: A Systematic Review

  2024cites this paper
• Neuroprotective actions of norepinephrine in neurological diseases

  2024cites this paper
• α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease

  2023cites this paper
• Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor

  2022cites this paper
• Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

  2021cites this paper
• G protein-coupled receptors that influence lifespan of human and animal models

  2021influential citation
• Alpha-1 blocker use increased risk of subsequent renal cell carcinoma: A nationwide population-based study in Taiwan

  2020cites this paper
• α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

  2020cites this paper
• Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation

  2019cites this paper
• The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction Headrick,

  2019cites this paper
• Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function

  2018cites this paper
• Atrial fibrillation in cancer patients: Hindsight, insight and foresight.

  2017cites this paper
• The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction.

  2017cites this paper
• Label-Free Dynamic Mass Redistribution Reveals Low-Density, Prosurvival α1B-Adrenergic Receptors in Human SW480 Colon Carcinoma Cells

  2017cites this paper
• An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

  2017cites this paper
• The role of α1-adrenergic receptors in regulating metabolism: increased glucose tolerance, leptin secretion and lipid oxidation

  2017cites this paper
• Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse

  2016cites this paper
• Molecular Mechanisms Underlying Psychological Stress and Cancer.

  2016cites this paper
• Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions

  2016cites this paper
• Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?

  2016cites this paper