Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Oncology Report

• Publication date

  2009-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3892/OR_00000384PMID 19424633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450.

  2009cited by this paper
• Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism

  2008cited by this paper
• Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.

  2007cited by this paper
• Antioxidant and anticancer activity of 3‘‐formyl‐4’, 6‘‐dihydroxy‐2’‐methoxy‐5‘‐methylchalcone and (2S)‐8‐formyl‐5‐hydroxy‐7‐methoxy‐6‐methylflavanone

  2007cited by this paper
• Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells

  2006cited by this paper
• Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity.

  2006cited by this paper
• Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).

  2006cited by this paper
• Flavonoid glycosides inhibit oral cancer cell proliferation — role of cellular uptake and hydrolysis to the aglycones

  2005cited by this paper
• Analysis and quantification of flavonoidic compounds from Portuguese olive (Olea Europaea L.) leaf cultivars

  2005cited by this paper
• In vitro antioxidant activity of some Teucrium species (Lamiaceae).

  2005cited by this paper
• Increase of Bax/ Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line.

  2005cited by this paper
• Targeted inhibition of the epidermal growth factor receptor‐tyrosine kinase by ZD1839 (‘Iressa’) induces cell‐cycle arrest and inhibits proliferation in prostate cancer cells

  2004cited by this paper
• Cytochrome P450 enzymes: novel options for cancer therapeutics.

  2004cited by this paper
• Molecular mechanisms underlying the interaction between ZD1839 (‘Iressa’) and cisplatin/5-fluorouracil

  2003cited by this paper
• Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.

  2003cited by this paper
• The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1

  2002cited by this paper
• Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.

  2001cited by this paper
• Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.

  2000cited by this paper
• Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor

  1999cited by this paper
• Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity.

  1998cited by this paper

• Protective Effect of Flavonoids in Ulcerative Colitis: A Systematic Review and Meta‐Analysis of Preclinical Studies

  2026cites this paper
• Hepatoprotective effect of diosmetin against thioacetamide-induced liver injury via modulating Bax/NF-κB/caspase-3/Nrf-2/PPARϒ signaling pathway in rats

  2025cites this paper
• Discovery of Highly Selective CYP1B1 Inhibitors.

  2025cites this paper
• Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice

  2025cites this paper
• Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells

  2025cites this paper
• An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish

  2024cites this paper
• Therapeutic potential of synthetic and natural iron chelators against ferroptosis

  2024cites this paper
• Synergistic anti-tumorigenic effect of diosmetin in combination with 5-fluorouracil on human colon cancer xenografts in nude mice.

  2024cites this paper
• Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression

  2024cites this paper
• Enhanced solubility and in vitro drug release of diosmetin from soy lecithin based‐diosmetin phytosome

  2024cites this paper
• Flavonoids: As omnipotent candidates for cancer management

  2023cites this paper
• Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives

  2023cites this paper
• Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

  2023cites this paper
• Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis

  2022cites this paper
• Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13

  2022cites this paper
• Preparation of a metal organic framework (MOF)-based monolithic column for the solid-phase extraction (SPE) of diosmetin from traditional Chinese medicine with determination by high-performance liquid chromatography (HPLC)

  2022cites this paper
• Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update.

  2022cites this paper
• Function and Application of Flavonoids in the Breast Cancer

  2022cites this paper
• Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events

  2021cites this paper
• Synergistic Effects of 5-Fluorouracil in Combination with Diosmetin in Colorectal Cancer Cells

  2021cites this paper
• Diosmetin and tamarixetin (methylated flavonoids): A review on their chemistry, sources, pharmacology, and anticancer properties

  2021cites this paper
• Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells

  2021cites this paper
• The ameliorating effect of Terminalia muelleri extract on oxidative stress–related factors in induced hepatocellular carcinoma rat model

  2021cites this paper
• Comprehensive analysis of genomic alterations, clinical outcomes, putative functions and potential therapeutic value of MMP11 in human breast cancer

  2020cites this paper
• Diosmetin Mitigates Cognitive and Memory Impairment Provoked by Chronic Unpredictable Mild Stress in Mice

  2020cites this paper
• Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer

  2020cites this paper
• Assessing the Anti-cancer Therapeutic Mechanism of a Herbal Combination for Breast Cancer on System-level by a Network Pharmacological Approach

  2020cites this paper
• Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

  2020cites this paper
• Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties

  2020cites this paper
• Protective effect of Diosmin against benzo(a)pyrene‐induced lung injury in Swiss Albino Mice

  2020cites this paper
• Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated from Dracocephalum peregrinum L.

  2020cites this paper
• Inhibition of ubiquitin specific protease 17 restrains prostate cancer proliferation by regulation of epithelial-to-mesenchymal transition (EMT) via ROS production.

  2019cites this paper
• Evaluation of Anti-Tumorigenic Effects of Diosmetin against Human Colon Cancer Xenografts in Athymic Nude Mice

  2019cites this paper
• Investigations on the structural, vibrational, computational, and molecular docking studies on potential antidiabetic chemical agent Diosmetin

  2019cites this paper
• Polymethoxyflavones: Chemistry and Molecular Mechanisms for Cancer Prevention and Treatment

  2019cites this paper
• Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer

  2019cites this paper
• Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes.

  2019cites this paper
• Flavonoids as Potential Anticancer Agents in Clinics: Where Have We Reached So Far?

  2019cites this paper
• Anti-Proliferation and Pro-Apoptotic Effects of Diosmetin via Modulating Cell Cycle Arrest and Mitochondria-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cells

  2019cites this paper
• Screening of flavonoid aglycons’ metabolism mediated by the human liver cytochromes P450

  2019cites this paper
• Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer.

  2019cites this paper
• Anti-Proliferation, Pro-Apoptosis and Anti-Migration Effects of Ginkgolic Acid C13:0 Isolated from Ginkgo Biloba Exocarp in MCF-7 and 4T-1 Breast Cancer Cells

  2018cites this paper
• Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.

  2018cites this paper
• Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD).

  2018cites this paper
• Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1/CYP1B1 enzyme induction and CYP1A1/CYP1B1-mediated metabolism to the product 4' hydroxy tangeretin.

  2018cites this paper
• Acute and subacute toxicity and chemical constituents of the hydroethanolic extract of Verbena litoralis Kunth.

  2018cites this paper
• Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest

  2018cites this paper
• Inhibition of Human Cytochrome P450-3A4 isoform by Crude Extracts from Acai Berry

  2018cites this paper
• Diosmetin, a Potential p53 Activator, Performs Anticancer Effect by Regulating Cell Cycling and Cell Proliferation in HepG2 Cells.

  2017cites this paper
• Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome

  2017cites this paper
• Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.

  2017influential citation
• Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.

  2017cites this paper
• Inhibitors of cytochrome P450 (CYP) 1B1.

  2017cites this paper
• Diosmin reduces cell viability of A431 skin cancer cells through apoptotic induction

  2017cites this paper
• Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells

  2016cites this paper
• Flavonoids and Naphthoflavonoids: Wider Roles in the Modulation of Cytochrome P450 Family 1 Enzymes

  2016cites this paper
• Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).

  2016cites this paper
• Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP-2 and MMP-9

  2016cites this paper
• Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives.

  2016cites this paper
• Diosmetin prevents TGF-β1-induced epithelial-mesenchymal transition via ROS/MAPK signaling pathways.

  2016cites this paper
• Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells

  2016cites this paper
• Bioassay-Guided Fractionation and In Vitro Antiproliferative Effects of Fractions of Artemisia nilagirica on THP-1 cell line

  2016cites this paper
• Flavonoid intake and all-cause mortality.

  2015cites this paper
• Differential metabolomic analysis of the potential antiproliferative mechanism of olive leaf extract on the JIMT-1 breast cancer cell line.

  2015cites this paper
• Evaluating Nutraceuticals for Selective Toxicity Toward Leukemia Stem Cells

  2015cites this paper
• Synthesis and evaluation of anti-cancer activity of some 6-Aminoflavones

  2015cites this paper
• Effect of diosmetin on airway remodeling in a murine model of chronic asthma.

  2015cites this paper
• Advances in methods for predicting phase I metabolism of polyphenols.

  2014cites this paper
• Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB.

  2014cites this paper
• henolic compounds and flavonoids from kinnow peel and their microbial activity

  2014cites this paper
• Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.

  2014cites this paper
• Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A.

  2014cites this paper
• In silico metabolism studies of dietary flavonoids by CYP1A2 and CYP2C9

  2013cites this paper
• Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice

  2013cites this paper
• Redox modulation of the DNA damage response.

  2012cites this paper
• Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings

  2012cites this paper
• Probing the binding of the flavonoid diosmetin to human serum albumin by multispectroscopic techniques.

  2012cites this paper
• Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.

  2012cites this paper
• Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.

  2012cites this paper
• Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis

  2011cites this paper
• A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

  2011cites this paper
• Flavonoids: A versatile source of anticancer drugs

  2011cites this paper
• Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.

  2011cites this paper
• Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer

  2010cites this paper
• Author ' s personal copy Dietary fl avonoids in cancer therapy and prevention : Substrates and inhibitors of cytochrome P 450 CYP 1 enzymes

  2010cites this paper
• Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors.

  2010cites this paper
• Bioavailability challenges associated with development of anti-cancer phenolics.

  2010cites this paper
• Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.

  2010cites this paper
• CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.

  2009influential citation
• The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.

  2009cites this paper
• Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

  2009cites this paper