Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Structure

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0969-2126(00)00172-6PMID 10997901
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ribbons.

  2019cited by this paper
• Protein structural topology: Automated analysis and diagrammatic representation

  2008cited by this paper
• The Role of an Iron-Sulfur Cluster in an Enzymatic Methylation Reaction

  1999cited by this paper
• A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase.

  1999cited by this paper
• Direct measurement of the pKa of aspartic acid 26 in Lactobacillus casei dihydrofolate reductase: implications for the catalytic mechanism.

  1999cited by this paper
• XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.

  1999cited by this paper
• Further additions to MolScript version 1.4, including reading and contouring of electron-density maps.

  1999cited by this paper
• Automated MAD and MIR structure solution

  1999cited by this paper
• Recent improvements of the ProDom database of protein domain families

  1999cited by this paper
• Motif-based searching in TOPS protein topology databases

  1999cited by this paper
• ESPript: analysis of multiple sequence alignments in PostScript

  1999cited by this paper
• Glutamate mutase from Clostridium cochlearium: the structure of a coenzyme B12-dependent enzyme provides new mechanistic insights.

  1999cited by this paper
• Binding of (6R,S)-methyltetrahydrofolate to methyltransferase from Clostridium thermoaceticum: role of protonation of methyltetrahydrofolate in the mechanism of methyl transfer.

  1999cited by this paper
• Mechanism of transfer of the methyl group from (6S)-methyltetrahydrofolate to the corrinoid/iron-sulfur protein catalyzed by the methyltransferase from Clostridium thermoaceticum: a key step in the Wood-Ljungdahl pathway of acetyl-CoA synthesis.

  1999cited by this paper
• A corrinoid-dependent catabolic pathway for growth of a Methylobacterium strain with chloromethane.

  1999cited by this paper
• SHELX Applications to Macromolecules

  1998cited by this paper
• O-demethylase from Acetobacterium dehalogenans--cloning, sequencing, and active expression of the gene encoding the corrinoid protein.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Characterization of the Zinc Binding Site in Methionine Synthase Enzymes of Escherichia coli: The Role of Zinc in the Methylation of Homocysteine

  1998cited by this paper
• Direct methods for solving macromolecular structures

  1998cited by this paper
• Clustered Genes Encoding the Methyltransferases of Methanogenesis from Monomethylamine

  1998cited by this paper
• Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro.

  1998cited by this paper
• Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism.

  1998cited by this paper
• Classifying a protein in the CATH database of domain structures.

  1998cited by this paper
• Cloning, sequencing and expression of the genes encoding the sodium translocating N 5‐methyltetrahydromethanopterin:coenzyme M methyltransferase of the methylotrophic archaeon Methanosarcina mazei Gö1

  1998cited by this paper
• Role of the [4Fe-4S] cluster in reductive activation of the cobalt center of the corrinoid iron-sulfur protein from Clostridium thermoaceticum during acetate biosynthesis.

  1998cited by this paper
• Tetramethylammonium:coenzyme M methyltransferase system from Methanococcoides sp.

  1998cited by this paper
• Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction.

  1997cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Structural characterization of modified folates in Archaea.

  1997cited by this paper
• SHELXL: high-resolution refinement.

  1997cited by this paper
• Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

  1997cited by this paper
• Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

  1997cited by this paper
• Cobalamin-dependent methionine synthase from Escherichia coli: involvement of zinc in homocysteine activation.

  1997cited by this paper
• Structure-based perspectives on B12-dependent enzymes.

  1997cited by this paper
• Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate

  1997cited by this paper
• Reconstitution of Monomethylamine:Coenzyme M Methyl Transfer with a Corrinoid Protein and Two Methyltransferases Purified fromMethanosarcina barkeri *

  1997cited by this paper
• Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine.

  1997cited by this paper
• The Eastern and Western branches of the Wood/Ljungdahl pathway: how the East and West were won

  1997cited by this paper
• Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri

  1997cited by this paper
• VERIFY3D: assessment of protein models with three-dimensional profiles.

  1997cited by this paper
• Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.

  1997cited by this paper
• Methods used in the structure determination of bovine mitochondrial F1 ATPase.

  1996cited by this paper
• How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.

  1996cited by this paper
• Sodium ion translocation by N5-methyltetrahydromethanopterin: coenzyme M methyltransferase from Methanosarcina mazei Gö1 reconstituted in ether lipid liposomes.

  1996cited by this paper
• Studies on methyl chloride dehalogenase and O-demethylase in cell extracts of the homoacetogen strain MC based on a newly developed coupled enzyme assay

  1996cited by this paper
• Mechanistic enzymology of a methyltetrahydrofolate: Corrinoid/iron -sulfur protein methyltransferase from {\it Clostridium thermoaceticum\/} of the acetyl -CoA pathway

  1996cited by this paper
• The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12.

  1996cited by this paper
• Surprising similarities in structure comparison.

  1996cited by this paper
• Preliminary X-ray crystallographic study of methyltetrahydrofolate: corrinoid/iron sulfur protein methyltransferase from Clostridium thermoaceticum.

  1995cited by this paper
• Mechanistic studies of the methyltransferase from Clostridium thermoaceticum: origin of the pH dependence of the methyl group transfer from methyltetrahydrofolate to the corrinoid/iron-sulfur protein.

  1995cited by this paper
• SCOP: a structural classification of proteins database for the investigation of sequences and structures.

  1995cited by this paper
• The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits.

  1995cited by this paper
• Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase

  1995cited by this paper
• Structural and electronic factors in heterolytic cleavage: formation of the Co(I) intermediate in the corrinoid/iron-sulfur protein from Clostridium thermoaceticum.

  1995cited by this paper
• Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).

  1995cited by this paper
• Dali: a network tool for protein structure comparison.

  1995cited by this paper
• How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase.

  1994cited by this paper
• Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes.

  1994cited by this paper
• The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum

  1994cited by this paper
• Raster3D Version 2.0. A program for photorealistic molecular graphics.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Cofactor contents of methanogenic bacteria reviewed.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Sequence and expression of the gene encoding the corrinoid/iron-sulfur protein from Clostridium thermoaceticum and reconstitution of the recombinant protein to full activity.

  1993cited by this paper
• Crystal structures of chicken liver dihydrofolate reductase: binary thioNADP+ and ternary thioNADP+.biopterin complexes.

  1993cited by this paper
• Protein structure comparison by alignment of distance matrices.

  1993cited by this paper
• X-ray absorption spectroscopy of the corrinoid/iron-sulfur protein involved in acetyl coenzyme A synthesis by Clostridium thermoaceticum

  1993cited by this paper
• Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling.

  1992cited by this paper
• Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.

  1992cited by this paper
• Assessment of protein models with three-dimensional profiles

  1992cited by this paper
• OLIGSCAN: a computer program to assist in the design of PCR primers homologous to multiple DNA sequences.

  1992cited by this paper
• Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling.

  1992cited by this paper
• Glutamate mutase from Clostridium cochlearium. Purification, cobamide content and stereospecific inhibitors.

  1992cited by this paper
• Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement

  1991cited by this paper
• Structural characteristics of methanogenic cofactors in the non-methanogenic archaebacterium Archaeoglobus fulgidus.

  1991cited by this paper
• A workbench for multiple alignment construction and analysis

  1991cited by this paper
• Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.

  1990cited by this paper
• UNUSUAL COENZYMES OF METHANOGENESIS

  1990cited by this paper
• Cobalamin‐dependent methionine synthase

  1990cited by this paper
• Cobamide-dependent methyl transferases.

  1990cited by this paper
• Spectroelectrochemical studies of the corrinoid/iron-sulfur protein involved in acetyl coenzyme A synthesis by Clostridium thermoaceticum.

  1989cited by this paper
• Cloning and expression of the gene cluster encoding key proteins involved in acetyl-CoA synthesis in Clostridium thermoaceticum: CO dehydrogenase, the corrinoid/Fe-S protein, and methyltransferase.

  1989cited by this paper
• Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate.

  1988cited by this paper
• Stereochemistry of acetic acid formation from 5-methyltetrahydrofolate by Clostridium thermoaceticum

  1987cited by this paper
• Formation of methylcoenzyme M from formaldehyde by cell‐free extracts of Methanobacterium thermoautotrophicum. Evidence for the involvement of a corrinoid‐containing methyltransferase

  1987cited by this paper
• Mössbauer, EPR, and optical studies of the corrinoid/iron-sulfur protein involved in the synthesis of acetyl coenzyme A by Clostridium thermoaceticum.

  1987cited by this paper
• Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67.

  1986cited by this paper
• Unusual coenzymes of methanogenesis.

  1985cited by this paper
• Theoretical studies on the activation of the pterin cofactor in the catalytic mechanism of dihydrofolate reductase.

  1985cited by this paper
• Acetate synthesis from carbon monoxide by Clostridium thermoaceticum. Purification of the corrinoid protein.

  1984cited by this paper
• A man-machine interface for interpreting electron density maps

  1982cited by this paper
• Purification of five components from Clostridium thermoaceticum which catalyze synthesis of acetate from pyruvate and methyltetrahydrofolate. Properties of phosphotransacetylase.

  1981cited by this paper
• Solvent content of protein crystals.

  1968cited by this paper

• Structural Snapshots of B12-Dependent Methionine Synthase’s Catalytic Conformations

  2026cites this paper
• Genomic potential for mercury biotransformation in marine sediments across marginal slope to hadal zone

  2025cites this paper
• Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis

  2024cites this paper
• Evidence for corrin biosynthesis in the last universal common ancestor

  2024cites this paper
• S-adenosyl-L-methionine is the unexpected methyl donor for the methylation of mercury by the membrane-associated HgcAB complex

  2024cites this paper
• The inorganic chemistry of the cobalt corrinoids - an update.

  2023cites this paper
• Phylogenetic and ecophysiological novelty of subsurface mercury methylators in mangrove sediments

  2023cites this paper
• Moorella thermoacetica: A Promising Cytochrome- and Quinone-Containing Acetogenic Bacterium as Platform For A CO2-based Bioeconomy

  2023cites this paper
• Chemical biology and medicinal chemistry of RNA methyltransferases

  2022cites this paper
• Genome-Scale Analysis of Acetobacterium woodii Identifies Translational Regulation of Acetogenesis

  2021cites this paper
• Methyl transfer reactions catalyzed by cobalamin-dependent enzymes: Insight from molecular docking.

  2020cites this paper
• Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium Akkermansia muciniphila

  2020cites this paper
• Syngas Fermentation for Bioethanol and Bioproducts

  2019cites this paper
• Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

  2019cites this paper
• The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.

  2018cites this paper
• Towards the structural characterization of the human methyltransferome.

  2018cites this paper
• Mercury Methylation by Cobalt Corrinoids: Relativistic Effects Dictate the Reaction Mechanism.

  2016cites this paper
• Site-Directed Mutagenesis of HgcA and HgcB Reveals Amino Acid Residues Important for Mercury Methylation

  2015cites this paper
• Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation.

  2015influential citation
• Anaerobic O-demethylation in acetobacterium dehalogenans : interaction mediated by O-demethylase components

  2014influential citation
• Weak protein–ligand interactions studied by small‐angle X‐ray scattering

  2014cites this paper
• A TALE OF TWO METHYLATION MODIFICATIONS IN ARCHAEAL RNAs

  2014cites this paper
• Methylenetetrahydrofolate reductase: biochemical characterization and medical significance.

  2013cites this paper
• The Genetic Basis for Bacterial Mercury Methylation

  2013cites this paper
• Mechanistic insights for formation of an organometallic Co-C bond in the methyl transfer reaction catalyzed by methionine synthase.

  2013cites this paper
• B 12 Enzymes, Function, and Small Molecules as Models

  2013cites this paper
• Visualizing molecular juggling within a B[subscript 12]-dependent methyltransferase complex

  2012cites this paper
• Visualising molecular juggling within a B12-dependent methyltransferase complex

  2012cites this paper
• Transient B12-Dependent Methyltransferase Complexes Revealed by Small-Angle X-ray Scattering

  2012cites this paper
• Biological conversion of carbon monoxide: rich syngas or waste gases to bioethanol

  2011cites this paper
• Efficient expression and purification of methyltransferase in acetyl-coenzyme a synthesis pathway of the human pathogen Clostridium difficile.

  2011cites this paper
• Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway.

  2011cites this paper
• Ether cleaving methyltransferases of the strict anaerobe Acetobacterium dehalogenans: controlling the substrate spectrum by genetic engineering of the N‐terminus

  2010cites this paper
• Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state.

  2010cites this paper
• Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (MeTr): protonation state of the ligand and active-site residues.

  2009cites this paper
• Cobalamin- and corrinoid-dependent enzymes.

  2009cites this paper
• Computational Studies: B12 Cofactors and their Interaction with Enzyme Active Sites

  2009cites this paper
• Enzymology of the Wood–Ljungdahl Pathway of Acetogenesis

  2008cites this paper
• Catalysis of methyl group transfers involving tetrahydrofolate and B(12).

  2008cites this paper
• Acetogenesis and the Wood-Ljungdahl pathway of CO(2) fixation.

  2008cites this paper
• CO Dehydrogenase/Acetyl‐CoA Synthase

  2008cites this paper
• Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance.

  2008cites this paper
• Cobalamin-dependent and cobamide-dependent methyltransferases.

  2008cites this paper
• Pulse-Chase Studies of the Synthesis of Acetyl-CoA by Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase

  2008cites this paper
• Biological Organometallic Chemistry of B12

  2007cites this paper
• Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer

  2007cites this paper
• Inhibition of cobalamin‐dependent methionine synthase by substituted benzo‐fused heterocycles

  2007cites this paper
• Spectroscopic studies of the corrinoid/iron-sulfur protein from Moorella thermoacetica.

  2006cites this paper
• Metals and their scaffolds to promote difficult enzymatic reactions.

  2006cites this paper
• Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex

  2006cites this paper
• Structural insights into methyltransfer reactions of a corrinoid iron–sulfur protein involved in acetyl-CoA synthesis

  2006cites this paper
• Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major roles in folate binding and catalysis and a minor role in flavin reactivity.

  2005cites this paper
• Chemistry and enzymology of vitamin B12.

  2005cites this paper
• Measurement of energetics of conformational change in cobalamin-dependent methionine synthase.

  2004cites this paper
• Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.

  2004cites this paper
• Life with Carbon Monoxide

  2004cites this paper
• Cobalamin-Independent Methionine Synthase (MetE): A Face-to-Face Double Barrel That Evolved by Gene Duplication

  2004cites this paper
• CloN6, a Novel Methyltransferase Catalysing the Methylation of the Pyrrole‐2‐carboxyl Moiety of Clorobiocin

  2003cites this paper
• 68 – Structure, Reactions, and Functions of B12 and B12-Proteins

  2003cites this paper
• How unique is the genetic code?

  2003cites this paper
• Chélation du fer dans la thérapie antipaludique

  2003cites this paper
• Factors modulating conformational equilibria in large modular proteins: A case study with cobalamin-dependent methionine synthase

  2003cites this paper
• Cobalamin-dependent methionine synthase: probing the role of the axial base in catalysis of methyl transfer between methyltetrahydrofolate and exogenous cob(I)alamin or cob(I)inamide.

  2003cites this paper
• The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes.

  2003cites this paper
• Review: Biological methylation of less-studied elements

  2002cites this paper
• A New UAG-Encoded Residue in the Structure of a Methanogen Methyltransferase

  2002cites this paper
• Making Methionine: A Love Affair with Folate

  2002cites this paper
• Methionine Synthase, Cobalamin-Dependent

  2002cites this paper
• Rapid kinetic studies of acetyl-CoA synthesis: evidence supporting the catalytic intermediacy of a paramagnetic NiFeC species in the autotrophic Wood-Ljungdahl pathway.

  2002cites this paper
• Cobalamin-dependent methyltransferases.

  2001cites this paper
• Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase.

  2001cites this paper
• Characterization of a Three-Component Vanillate O-Demethylase from Moorella thermoacetica

  2001cites this paper
• The Na(+)-translocating methyltransferase complex from methanogenic archaea.

  2001cites this paper
• Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase.

  2000cites this paper