Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses were associated with prolonged antigen presentation by dendritic cells (DCs), which maintained T cell/DC interactions into stage 3 (>72 hr) of activation. Blocking stage 3 interactions ablated Tfh generation, demonstrating a causal link between T cell-DC behaviour and functional outcomes. The current data therefore explain how duration of antigen presentation affects the dynamics of T cell-DC interactions and consequently determine Tfh cell differentiation in the developing immune response. DOI: http://dx.doi.org/10.7554/eLife.06994.001

• Publication year

  2015

• Venue

  eLife

• Publication date

  2015-08-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.7554/eLife.06994PMID 26258879PMCID 4558563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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