Insulin-like growth factor binding protein-2 stimulates proliferation and activates multiple cascades of the mitogen-activated protein kinase pathways in NIH-OVCAR3 human epithelial ovarian cancer cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Biology & Therapy

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cbt.5.2.2333PMID 16357519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IGF-independent actions of IGFBPs

  2007cited by this paper
• Molecular Cancer Insulin-like Growth Factor Binding Protein 2 Promotes Ovarian Cancer Cell Invasion

  2005cited by this paper
• Production of insulin-like growth factor binding proteins by human ovarian carcinoma cells

  2005cited by this paper
• Parc: a cytoplasmic anchor for p53.

  2003cited by this paper
• Nerve Growth Factor Stimulates Proliferation and Survival of Human Breast Cancer Cells through Two Distinct Signaling Pathways*

  2001cited by this paper
• High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model

  2000cited by this paper
• Differential IGF‐independent effects of insulin‐like growth factor binding proteins (1–6) on apoptosis of breast epithelial cells

  1999cited by this paper
• Cancer statistics, 1999

  1999cited by this paper
• The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.

  1998cited by this paper
• Molecular mechanisms to regulate the activities of insulin-like growth factors : proceedings of the 4th International Symposium on Insulin-like Growth Factors, at Tokyo International Forum, Tokyo, Japan, 21-24 October 1997

  1998cited by this paper
• Placenta growth factor (PlGF) mRNA expression in brain tumors

  1998cited by this paper
• Growth factors and ovarian cancer

  1998influential reference
• Differential expression of insulin-like growth factor binding proteins in high versus low Gleason score prostate cancer.

  1998cited by this paper
• Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor.

  1997cited by this paper
• Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

  1997cited by this paper
• The Mouse Extracellular Signal-regulated Kinase 2 Gene

  1997cited by this paper
• Role of insulin-like growth factor binding protein-2 and its limited proteolysis in neuroblastoma cell proliferation: modulation by transforming growth factor-beta and retinoic acid.

  1997cited by this paper
• Effects of Growth Hormone and Insulin-like Growth Factor I on Salinity Tolerance and Gill Na + , K +-ATPase in Atlantic Salmon ( Salmo salar ) : Interaction with Cortisol

  1996cited by this paper
• Effects of growth hormone and insulin-like growth factor I on salinity tolerance and gill Na+, K+-ATPase in Atlantic salmon (Salmo salar): interaction with cortisol.

  1996cited by this paper
• Selective interaction of JNK protein kinase isoforms with transcription factors.

  1996cited by this paper
• Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid.

  1996cited by this paper
• Tissue-targeted antisense c-fos retroviral vector inhibits established breast cancer xenografts in nude mice.

  1996cited by this paper
• ATF‐2 is preferentially activated by stress‐activated protein kinases to mediate c‐jun induction in response to genotoxic agents.

  1995cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Insulin-like growth factors and their binding proteins: biological actions.

  1995cited by this paper
• Growth-control of human ovarian-carcinoma cells by insulin-like growth-factors.

  1995cited by this paper
• Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)

  1995cited by this paper
• Expression of the heat shock protein HSP27 in human ovarian cancer.

  1995cited by this paper
• REGULATION OF NUCLEAR TRANSCRIPTION FACTORS BY STRESS SIGNALS

  1995cited by this paper
• Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue.

  1994cited by this paper
• Immunohistochemical localization of insulin-like growth factor 1 receptors in benign and malignant tissues of the female genital tract.

  1994cited by this paper
• Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.

  1994cited by this paper
• Expression of c-erbB-2, c-myc, and c-ras oncoproteins, insulin-like growth factor receptor I, and epidermal growth factor receptor in ovarian carcinoma.

  1994cited by this paper
• The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

  1994cited by this paper
• Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

  1993cited by this paper
• Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines.

  1993cited by this paper
• Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1

  1993cited by this paper
• Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.

  1993cited by this paper
• Regulation of insulin-like growth factor binding proteins in ovarian cancer cells by oestrogen.

  1993cited by this paper
• Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

  1993cited by this paper
• Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

  1993cited by this paper
• Growth factors in the ovary

  1992cited by this paper
• Expression of insulin-like growth factor I, its binding proteins, and its receptor in ovarian cancer.

  1991cited by this paper
• The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

  1991cited by this paper
• Production and functional characterization of human recombinant FGF-6 protein.

  1991cited by this paper
• Prognostic value of pS2 protein and receptors for epidermal growth factor (EGF-R), insulin-like growth factor-1 (IGF-1-R) and somatostatin (SS-R) in patients with breast and ovarian cancer.

  1990cited by this paper
• Cancer statistics

  1989cited by this paper
• Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function.

  1985influential reference
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Reproductive Biology and Endocrinology Open Access Mitogen-activated Protein Kinases in Normal and (pre)neoplastic Ovarian Surface Epithelium

  year unknowncited by this paper

• IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer

  2024cites this paper
• Signal transductions and nonalcoholic fatty liver

  2024cites this paper
• The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome

  2023cites this paper
• The “Sweet Spot” of Targeting Tumor Metabolism in Ovarian Cancers

  2022cites this paper
• Cardiometabolic comorbidities and epithelial ovarian cancer risk among African-American women in the African-American Cancer Epidemiology Study (AACES).

  2020cites this paper
• Insulin-Like Growth Factor Binding Protein-2 Promotes Proliferation and Predicts Poor Prognosis in Hepatocellular Carcinoma

  2020cites this paper
• GSG2 knockdown suppresses cholangiocarcinoma progression by regulating cell proliferation, apoptosis and migration

  2020cites this paper
• GSG2 knockdown suppresses cholangiocarcinoma progression by regulating cell proliferation, apoptosis and migration

  2020cites this paper
• IGFBP2 in cancer: Pathological role and clinical significance (Review).

  2020cites this paper
• Immunology and Immunotherapy of Ovarian Cancer

  2020cites this paper
• A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

  2019cites this paper
• Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.

  2019cites this paper
• IGFBP2 promotes the EMT of colorectal cancer cells by regulating E-cadherin expression.

  2019cites this paper
• Precision oncology : oncogenic stat3 signalling in brain tumours

  2019cites this paper
• Adeno-associated virus type 2-mediated gene transfer of a short hairpin-RNA targeting human IGFBP-2 suppresses the proliferation and invasion of MDA-MB-468 cells

  2018cites this paper
• Anthropometric characteristics and ovarian cancer risk and survival

  2018cites this paper
• IGFBP2 enhances adipogenic differentiation potentials of mesenchymal stem cells from Wharton's jelly of the umbilical cord via JNK and Akt signaling pathways

  2017cites this paper
• Phase II trial of albumin-bound paclitaxel and granulocyte macrophage colony-stimulating factor as an immune modulator in recurrent platinum resistant ovarian cancer.

  2017cites this paper
• IGF-binding protein 2 is a candidate target of therapeutic potential in cancer

  2016cites this paper
• DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity.

  2016cites this paper
• IGFBP2 POTENTIATES EGFR-STAT3 SIGNALING IN GLIOMA

  2015cites this paper
• IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

  2015cites this paper
• Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment

  2015cites this paper
• Cancer de l'ovaire : maintien de la rémission complète par le thé vert et identification de biomarqueurs pronostiques à caractère protéolytique

  2014cites this paper
• IGF binding proteins in cancer: mechanistic and clinical insights

  2014cites this paper
• Exogenous IGFBP-2 promotes proliferation, invasion, and chemoresistance to temozolomide in glioma cells via the integrin β1-ERK pathway

  2014cites this paper
• Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation

  2014cites this paper
• Plasma IGFBP-2 Levels after Postoperative Combined Radiotherapy and Chemotherapy Predict Prognosis in Elderly Glioblastoma Patients

  2014cites this paper
• Expression of GLP-1R protein and its clinical role in intrahepatic cholangiocarcinoma tissues

  2014cites this paper
• Signal transductions and nonalcoholic fatty liver: a mini-review.

  2014cites this paper
• Characterization of novel epigenetic targets in ovarian cancer

  2014cites this paper
• The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.

  2013cites this paper
• IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells

  2013cites this paper
• Regulation of protumorigenic pathways by Insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis

  2013cites this paper
• [The importance of glycemic load of the diet in the development of cancer].

  2013cites this paper
• The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis

  2012influential citation
• Overexpression of Runt-Related Transcription Factor-2 Is Associated with Advanced Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer

  2012cites this paper
• PKC Signaling is Involved in the Regulation of Progranulin (Acrogranin/PC-Cell-Derived Growth Factor/Granulin-Epithelin Precursor) Protein Expression in Human Ovarian Cancer Cell Lines

  2012cites this paper
• IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells.

  2011cites this paper
• The impact of diabetes on survival in women with ovarian cancer.

  2011cites this paper
• Profiling signatures of ovarian cancer tumour suppression using 2D-DIGE and 2D-LC-MS/MS with tandem mass tagging.

  2011cites this paper
• Somatostatin receptors in non-neuroendocrine malignancies: the potential role of somatostatin analogs in solid tumors.

  2011cites this paper
• Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus.

  2010cites this paper
• Patched1 Inhibits Epidermal Progenitor Cell Expansion and Basal Cell Carcinoma Formation by Limiting Igfbp2 Activity

  2010cites this paper
• JNK mediates insulin-like growth factor binding protein 2/integrin alpha5-dependent glioma cell migration.

  2010cites this paper
• Proteomic analysis of cell models of ovarian cancer tumour suppression

  2010cites this paper
• IGFBP2 promotes glioma tumor stem cell expansion and survival.

  2010cites this paper
• Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.

  2009cites this paper
• Insulin-like growth factor-binding protein contributes to the proliferation of less proliferative cells in forming skin equivalents.

  2009cites this paper
• Analysis of Gene Expression in Early-Stage Ovarian Cancer

  2008cites this paper
• Peripubertal Hyperinsulinemia Upregulates Phosphatidylinositol 3-Kinase/Akt Pathway in Rat Ovaries

  2008cites this paper
• Insulin-like Growth Factors and Ovarian Cancer Risk: A Nested Case-Control Study in Three Cohorts

  2007cites this paper
• Silencing of Insulin-like Growth Factor-binding Protein-2 in Human Glioblastoma Cells Reduces Both Invasiveness and Expression of Progression-associated Gene CD24*

  2007cites this paper
• IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer.

  2007cites this paper
• Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.

  2007cites this paper
• Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types

  2006cites this paper
• Role of the Insulin-like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis

  2004cites this paper