The Dynamics of Norovirus Outbreak Epidemics: Recent Insights

Noroviruses are a major cause of gastroenteritis outbreaks worldwide. Norovirus outbreaks frequently occur as epidemics which appear to be related to both genetic and environmental factors. This review considers recent progress in understanding these factors. The norovirus genome undergoes continuous change and this appears to be important in the persistence of the virus in the community. Studies on the common GII.4 genotype have shown that some norovirus outbreak epidemics involving this genotype are correlated with specific changes in the genome. In contrast to the growing understanding of the role of genetic factors in norovirus outbreak epidemics, the role of environmental factors is less well understood. Topics reviewed here include long term excretion of norovirus in some individuals, long term survivability of norovirus in the environment, the role of meteorological factors in the control of norovirus outbreaks and the possible zoonotic transmission of the virus.

• Publication year

  2011

• Venue

  International Journal of Environmental Research and Public Health

• Publication date

  2011-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/ijerph8041141PMID 21695033PMCID 3118882
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Outbreak of Canine Norovirus Infection in Young Dogs

  2010cited by this paper
• Novel Norovirus in Dogs with Diarrhea

  2010cited by this paper
• The Incidence of Norovirus-Associated Gastroenteritis Outbreaks in Victoria, Australia (2002–2007) and Their Relationship with Rainfall

  2010cited by this paper
• Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans.

  2010cited by this paper
• Norovirus Gastroenteritis, Carbohydrate Receptors, and Animal Models

  2010cited by this paper
• Molecular Changes Associated with Altered Patterns of Norovirus Outbreak Epidemics in Victoria, Australia, in 2006 to 2007

  2010cited by this paper
• Phylodynamic Reconstruction Reveals Norovirus GII.4 Epidemic Expansions and their Molecular Determinants

  2010cited by this paper
• Molecular and Epidemiological Characteristics of Norovirus Associated with Community-Based Sporadic Gastroenteritis Incidents and Norovirus Outbreaks in Victoria, Australia, 2002–2007

  2010cited by this paper
• Rapid Evolution of Pandemic Noroviruses of the GII.4 Lineage

  2010cited by this paper
• Divergent Evolution of Norovirus GII/4 by Genome Recombination from May 2006 to February 2009 in Japan

  2010cited by this paper
• Identification of a novel codon in the norovirus GII.4 polymerase region which acts as a marker of major GII.4 norovirus epidemics.

  2009cited by this paper
• Molecular Study of the Persistence of Infectious Human Norovirus on Food-Contact Surfaces

  2009cited by this paper
• Noroviruses: a comprehensive review.

  2009cited by this paper
• Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007.

  2009cited by this paper
• Genetic Heterogeneity and Recombination in Canine Noroviruses

  2009cited by this paper
• New Real-Time PCR Detects Prolonged Norovirus Excretion in Highly Immunosuppressed Patients and Children

  2009cited by this paper
• Evolutionary Dynamics of GII.4 Noroviruses over a 34-Year Period

  2009cited by this paper
• Molecular detection of norovirus in sheep and pigs in New Zealand farms.

  2009cited by this paper
• Norovirus epidemics are linked to two distinct sets of controlling factors.

  2009cited by this paper
• PRIMER OF EPIDEMIOLOGY

  2008cited by this paper
• Animal noroviruses.

  2008cited by this paper
• Norovirus Excretion in an Aged-Care Setting

  2008cited by this paper
• Detection and Molecular Characterization of a Canine Norovirus

  2008cited by this paper
• Progress in understanding norovirus epidemiology

  2008cited by this paper
• Chronic norovirus infection in renal transplant recipients.

  2008cited by this paper
• A Single Amino Acid Substitution in the Murine Norovirus Capsid Protein Is Sufficient for Attenuation In Vivo

  2008cited by this paper
• Norovirus pathogenesis: mechanisms of persistence and immune evasion in human populations

  2008cited by this paper
• Food-borne viruses in Europe network report: the norovirus GII.4 2006b (for US named Minerva-like, for Japan Kobe034-like, for UK V6) variant now dominant in early seasonal surveillance.

  2008cited by this paper
• Molecular changes in the norovirus polymerase gene and their association with incidence of GII.4 norovirus-associated gastroenteritis outbreaks in Victoria, Australia, 2001–2005

  2008cited by this paper
• Occurrence of Norovirus Infections Unrelated to Norovirus Outbreaks in an Asymptomatic Food Handler Population

  2008cited by this paper
• Norovirus in Captive Lion Cub (Panthera leo)

  2007cited by this paper
• Atypical Norovirus Epidemic in Hong Kong during Summer of 2006 Caused by a New Genogroup II/4 Variant

  2007cited by this paper
• Evaluation of Murine Norovirus, Feline Calicivirus, Poliovirus, and MS2 as Surrogates for Human Norovirus in a Model of Viral Persistence in Surface Water and Groundwater

  2007cited by this paper
• Norovirus recombination.

  2007cited by this paper
• Gastroenteritis Outbreak Caused by Waterborne Norovirus at a New Zealand Ski Resort

  2007cited by this paper
• Murine Noroviruses Comprising a Single Genogroup Exhibit Biological Diversity despite Limited Sequence Divergence

  2007cited by this paper
• Human Noroviruses in Swine and Cattle

  2007cited by this paper
• Inter-seasonal diversity of norovirus genotypes: Emergence and selection of virus variants

  2007cited by this paper
• Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis

  2006cited by this paper
• Laboratory diagnosis of norovirus.

  2006cited by this paper
• Norovirus classification and proposed strain nomenclature.

  2006cited by this paper
• Emergence of a New Norovirus Genotype II.4 Variant Associated with Global Outbreaks of Gastroenteritis

  2006cited by this paper
• Porcine Noroviruses Related to Human Noroviruses

  2005cited by this paper
• Evidence of Recombination in the Norovirus Capsid Gene

  2005cited by this paper
• Molecular and epidemiological features of norovirus‐associated gastroenteritis outbreaks in Victoria, Australia in 2001

  2005cited by this paper
• Asymptomatic Norovirus Infection in Mexican Children

  2005cited by this paper
• Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH).

  2004cited by this paper
• Failure to detect norovirus in a large group of asymptomatic individuals.

  2004cited by this paper
• Development and application of a capsid VP1 (region D) based reverse transcription PCR assay for genotyping of genogroup I and II noroviruses.

  2004cited by this paper
• Long-term features of norovirus gastroenteritis in the elderly.

  2004cited by this paper
• Mutation in a Lordsdale Norovirus Epidemic Strain as a Potential Indicator of Transmission Routes

  2004cited by this paper
• High number of norovirus outbreaks associated with a GGII.4 variant in The Netherlands and Elsewhere: Does this herald a worldwide increase?

  2004cited by this paper
• Evaluation and Comparison of Two Commercial Enzyme-Linked Immunosorbent Assay Kits for Detection of Antigenically Diverse Human Noroviruses in Stool Samples

  2004cited by this paper
• Emerging Genotype (GGIIb) of Norovirus in Drinking Water, Sweden

  2003cited by this paper
• A school outbreak of Norwalk-like virus: evidence for airborne transmission

  2003cited by this paper
• HIGH LEVEL EXCRETION OF NORWALK‐LIKE VIRUS FOLLOWING RESOLUTION OF CLINICAL ILLNESS

  2001cited by this paper
• Cold weather seasonality of gastroenteritis associated with Norwalk-like viruses.

  2000cited by this paper
• Inactivation of feline calicivirus, a Norwalk virus surrogate.

  1999cited by this paper
• An outbreak of viral gastroenteritis associated with consumption of sandwiches: implications for the control of transmission by food handlers

  1998cited by this paper
• Norwalk virus infection of volunteers: new insights based on improved assays.

  1994cited by this paper
• Prolonged outbreak of Norwalk gastroenteritis in an isolated guest house

  1985cited by this paper

• Mathematical and numerical investigations of fractional stochastic epidemic model

  2025cites this paper
• In-depth comparison of untargeted and targeted sequencing for detecting virus diversity in wastewater.

  2025cites this paper
• Targeting norovirus RdRp: A computational study on the inhibitory potential of ursolic acid and apigenin-7-O-glucoside

  2025cites this paper
• Surface-by-temperature interactions shape the relationship between viral free-living survival and reproduction

  2025cites this paper
• Multidisciplinary management of a norovirus outbreak in Tuscany, Italy

  2025cites this paper
• Asymptomatic norovirus infection during outbreaks in China: A systematic review and meta‐analysis

  2024cites this paper
• Prevalence of Norovirus Coinfection in Clostridioides difficile Toxin Positive Patients

  2024cites this paper
• A Novel Stochastic Model for Human Norovirus Dynamics: Vaccination Impact with Lévy Noise

  2024cites this paper
• Climate changes and food-borne pathogens: the impact on human health and mitigation strategy

  2024cites this paper
• Numerical Approach for Solving a Fractional-Order Norovirus Epidemic Model with Vaccination and Asymptomatic Carriers

  2023cites this paper
• Outdoor Absolute Humidity Predicts the Start of Norovirus GII Epidemics

  2023cites this paper
• Detection rates of norovirus gastroenteritis and factors associated with the infection before and during COVID-19 pandemic: a secondary analysis of surveillance data in Guangxi Zhuang Autonomous Region, Southern China

  2023cites this paper
• Development of enhanced primer sets for detection of Norovirus and Hepatitis A in food samples from Guayaquil (Ecuador) by reverse transcriptase-heminested PCR

  2023cites this paper
• Norovirus: An Overview of Virology and Preventative Measures

  2022cites this paper
• Nosocomial Infections Associated with Caesarean Section

  2022cites this paper
• Norovirus Genogroup II Epidemics and the Potential Effect of Climate Change on Norovirus Transmission in Taiwan

  2022cites this paper
• Norovirus disease among older adults

  2022cites this paper
• Impact of Levy noise on a stochastic Norovirus epidemic model with information intervention

  2022cites this paper
• Evaluation of Norovirus Reduction in Environmentally Contaminated Pacific Oysters During Laboratory Controlled and Commercial Depuration

  2021cites this paper
• Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: 2019/2020 Season in Guangzhou, China

  2021cites this paper
• Fractal–fractional and stochastic analysis of norovirus transmission epidemic model with vaccination effects

  2021influential citation
• Prevalence, Distribution, and Genotypes of Adenovirus and Norovirus in the Puzi River and Its Tributaries and the Surrounding Areas in Taiwan

  2021cites this paper
• The role of stem cell niche in intestinal aging.

  2020cites this paper
• Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: Winter 2019-2020 in Guangzhou

  2020cites this paper
• A novel screening tool for the health risk in recreational waters near estuary: The Carrying Capacity indicator.

  2019cites this paper
• Profile and Seasonal distribution of Acute Gastroenteritis cases admitted in Isolation Disease Hospital: A Record base Analysis

  2019cites this paper
• Preparation and Evaluation of Combined Detection of Norovirus GI and GII: An Innovative Fluorescent Particles Test Strip

  2018cites this paper
• Infectious risk assessment of reclaimed water by UF membrane treatment process focusing attention on norovirus

  2018cites this paper
• Immune Function and Micronutrient Requirements Change over the Life Course

  2018cites this paper
• Title Emergence of norovirus GI . 2 outbreaks in military campsin Singapore

  2018cites this paper
• Lactic Acid Bacteria and Foodborne Pathogens

  2018cites this paper
• Effectiveness of Rota Vaccine among Children in Babylon Province, Iraq

  2018cites this paper
• Sick Building Syndrome and Other Building-Related Illnesses

  2018cites this paper
• Genotyping and Phylogenic of Norovirus as Main Cause of Children Gastritis in Thi-Qar province

  2018cites this paper
• Pathogenic viruses in Finnish waters : occurrence, fate and control

  2018cites this paper
• Adaptive neuro-fuzzy inference system for predicting norovirus in drinking water supply

  2017influential citation
• Influence of School Year on Seasonality of Norovirus Outbreaks in Developed Countries

  2017cites this paper
• Effect of some Transition Complexes on Bacteria and Fungi Causes Gastroenteritis in Humans

  2017cites this paper
• Comparison of Adaptive Neuro-Fuzzy Inference System (ANFIS) and Gaussian Process for Machine Learning (GPML) Algorithms for the Prediction of Norovirus Concentration in Drinking Water Supply

  2017cites this paper
• Detection of respiratory syncytial virus specific antibody response in saliva of healthy Singaporeans

  2017cites this paper
• Temporal distribution of gastroenteritis viruses in Ouagadougou, Burkina Faso: seasonality of rotavirus

  2017cites this paper
• Norovirus transmission dynamics: a modelling review

  2017cites this paper
• Probiotics and antisecretory agents though costly are effective alone in mild to moderate non bacterial acute gastroenteritis

  2016cites this paper
• The epidemiology and evolution of norovirus in Australia

  2016cites this paper
• Removal characteristics and fluctuation of norovirus in a pilot-plant by an ultrafiltration membrane for the reclamation of treated sewage

  2016cites this paper
• Statistical methods for the spatio-temporal modelling of infectious disease spread

  2016cites this paper
• Arc discharge-mediated disassembly of viral particles in water.

  2016cites this paper
• Efficacy of common disinfectant/cleaning agents in inactivating murine norovirus and feline calicivirus as surrogate viruses for human norovirus.

  2015cites this paper
• Study of the Virucidal Potential of Organic Peroxyacids Against Norovirus on Food-Contact Surfaces

  2015cites this paper
• Development of Enhanced Primer Sets for Detection of Norovirus

  2015cites this paper
• Emergence of norovirus GI.2 outbreaks in military camps in Singapore.

  2015cites this paper
• Incorporating social contact data in spatio-temporal models for infectious disease spread

  2015cites this paper
• Matrix Approach for the Seasonal Infectious Disease Spread Prediction

  2015cites this paper
• Quantification of Human Norovirus GII on Hands of Mothers with Children Under the Age of Five Years in Bagamoyo, Tanzania.

  2015cites this paper
• Noroviruses associated with outbreaks of acute gastroenteritis in the State of Rio Grande do Sul, Brazil, 2004-2011.

  2014cites this paper
• Surveillance of pathogens causing gastroenteritis and characterization of norovirus and sapovirus strains in Shenzhen, China, during 2011

  2014cites this paper
• Chemical Derivatives of a Small Molecule Deubiquitinase Inhibitor Have Antiviral Activity against Several RNA Viruses

  2014cites this paper
• Molecular and clinical epidemiology of norovirus outbreaks in Spain during the emergence of GII.4 2012 variant.

  2014cites this paper
• A Novel RNA Virus Detection System Based on Duplex Specific Nuclease

  2014cites this paper
• CASE STUDY IN QUANTITATIVE MICROBIAL RISK ASSESSMENT OF RECLAIMED WATER BY THE ULTRA FILTRATION MEMBRANE PROCESS FOR AGRICULTURAL IRRIGATION

  2013cites this paper
• A Systematic Review and Meta-Analysis of the Global Seasonality of Norovirus

  2013influential citation
• Roles of sunlight and natural ventilation for controlling infection: historical and current perspectives

  2013cites this paper
• P2 domain profiles and shedding dynamics in prospectively monitored norovirus outbreaks.

  2013cites this paper
• Outbreaks of Human Norovirus in Sports Field

  2013cites this paper
• Mechanics of soft particle capture using nanofiber networks

  2013cites this paper
• Infection control in the post-antibiotic era

  2013cites this paper
• [Investigation of norovirus infection incidence among 0-5 years old children with acute gastroenteritis admitted to two different hospitals in ankara, Turkey].

  2013cites this paper
• Different norovirus genotypes in patients with gastroenteritis in Kuwait

  2013cites this paper
• Outbreak of gastroenteritis caused by norovirus GII.4 Sydney variant after a wedding reception at a resort/activity centre, Finland, August 2012

  2013cites this paper
• Roles of sunlight and natural ventilation for controlling infection: historical and current perspectives

  2013cites this paper
• A Food Handler-Associated, Foodborne Norovirus GII.4 Sydney 2012-Outbreak Following a Wedding Dinner, Austria, October 2012

  2013cites this paper
• The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

  2013cites this paper
• Molecular characterization of norovirus GII strains identified in Albania

  2013cites this paper
• Bioengineered probiotics, a strategic approach to control enteric infections

  2013cites this paper
• Noroviruses: Recent Updates

  2012cites this paper
• Increase of GII.2 norovirus infections during the 2009–2010 season in Osaka City, Japan

  2012cites this paper
• Outbreak column 2: norovirus, our perennial infection control winter challenge

  2012influential citation
• Picobirnavirus infections: viral persistence and zoonotic potential

  2012cites this paper
• Diversity of murine norovirus in wild-rodent populations: species-specific associations suggest an ancient divergence.

  2012cites this paper
• The Influence of Sunlight and Ventilation on Indoor Health: Infection Control for the Post-Antibiotic Era

  2012cites this paper
• Diverse norovirus genotypes identified in sewage-polluted river water in South Africa

  2012cites this paper
• Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers.

  2012cites this paper
• Modern Approaches in Probiotics Research to Control Foodborne Pathogens

  2012influential citation
• ctions : viral persistence and

  2012cites this paper
• Evaluation of norovirus persistence on farm and agriculturally- relevant environments

  2012cites this paper