Commentary: SLAM- and Nectin-4-Independent Noncytolytic Spread of Canine Distemper Virus in Astrocytes

As in the case of the small subset (8–20 per 1 million) of Measles Virus (MeV)-infected humans developing a peculiar neurological disease condition known as “subacute sclerosing panencephalitis” (SSPE) (Garg, 2008; Kweder et al., 2015), Canine Distemper Virus (CDV) may also give rise to a persistent, “brain-only” form of disease in dogs, known as “old dog encephalitis” (ODE) (Reuter and Schneider-Schaulies, 2010; Sato et al., 2012). Interestingly, peculiar forms of morbilliviral disease resembling those reported in MeV-infected patients and CDV-infected dogs have been also described among Cetacean Morbillivirus (CeMV)-infected striped dolphins (Stenella coeruleoalba) after the two major morbilliviral epidemics occurred in 1990–92 and 2006–08 in the Western Mediterranean. In a similar manner to what seen in CDV-affected canines and MeV-affected humans, dolphins hit by this form of infection harbor morbilliviral genome and/or antigens exclusively in their brain parenchyma (Domingo et al., 1995; Di Guardo et al., 2013).

• Publication year

  2016

• Venue

  Frontiers in Microbiology

• Publication date

  2016-12-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fmicb.2016.02011PMID 28018332PMCID 5145896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of Viral Antigens and Brain Ultrastructural Findings in Striped Dolphins (Stenella coeruleoalba) with ‘Brain-Only’ Dolphin morbillivirus Infection

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