Aryl Hydrocarbon Receptor Activation in Hematopoietic Stem/Progenitor Cells Alters Cell Function and Pathway-Specific Gene Modulation Reflecting Changes in Cellular Trafficking and Migration

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Pharmacology

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/mol.111.071381PMID 21791576PMCID PMC3187533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neural Precursor Cell Proliferation Is Disrupted Through Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

  2011cited by this paper
• Gα13 and Rho Mediate Endosomal Trafficking of CXCR4 into Rab11+ Vesicles upon Stromal Cell-Derived Factor-1 Stimulation

  2011cited by this paper
• Nucleophosmin gene mutations promote NIH3T3 cell migration and invasion through CXCR4 and MMPs.

  2011cited by this paper
• Aryl Hydrocarbon Receptor-Null Allele Mice Have Hematopoietic Stem/Progenitor Cells with Abnormal Characteristics and Functions

  2011cited by this paper
• Identification of Stage-Specific Gene Modulation during Early Thymocyte Development by Whole-Genome Profiling Analysis after Aryl Hydrocarbon Receptor Activation

  2010cited by this paper
• TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts.

  2010cited by this paper
• An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

  2010influential reference
• Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.

  2010cited by this paper
• HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta.

  2010influential reference
• Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

  2010influential reference
• What is the true nature of the osteoblastic hematopoietic stem cell niche?

  2009cited by this paper
• The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

  2009cited by this paper
• Faculty Opinions recommendation of Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

  2009cited by this paper
• Ah receptor and NF-kappaB interplay on the stage of epigenome.

  2009cited by this paper
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

  2009cited by this paper
• Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells.

  2009cited by this paper
• Marginal expression of CXCR4 on c-kit+Sca-1+Lineage− hematopoietic stem/progenitor cells

  2009cited by this paper
• An enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to TCDD.

  2008cited by this paper
• CXCR4 is required for the quiescence of primitive hematopoietic cells

  2008cited by this paper
• Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor*

  2008cited by this paper
• Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes.

  2007cited by this paper
• Limiting factors in murine hematopoietic stem cell assays.

  2007influential reference
• The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease

  2006influential reference
• Dioxin‐induced chloracne – reconstructing the cellular and molecular mechanisms of a classic environmental disease

  2006cited by this paper
• Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

  2004cited by this paper
• Signaling via the AHR leads to enhanced usage of CD44v10 by murine fetal thymic emigrants: possible role for CD44 in emigration.

  2004cited by this paper
• Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

  2004cited by this paper
• TCDD treatment eliminates the long-term reconstitution activity of hematopoietic stem cells.

  2003influential reference
• TM4: a free, open-source system for microarray data management and analysis.

  2003cited by this paper
• Agent Orange and Cancer: An Overview for Clinicians

  2003influential reference
• Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.

  2002cited by this paper
• The aryl hydrocarbon receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2000influential reference
• Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J mice.

  2000influential reference
• Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells.

  1998influential reference
• Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation.

  1994cited by this paper
• Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1993cited by this paper
• The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate.

  1993cited by this paper
• An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin.

  1992cited by this paper
• Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1990influential reference
• Studies on the mechanism of toxicity of the chlorinated dibenzo-p-dioxins.

  1973cited by this paper

• Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells

  2025cites this paper
• Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection.

  2024cites this paper
• Differential Modulation of Dendritic Cell Biology by Endogenous and Exogenous Aryl Hydrocarbon Receptor Ligands

  2023cites this paper
• Tryptophan and kynurenine levels in patients with obstructive sleep apnea syndrome

  2022cites this paper
• Impact of the aryl hydrocarbon receptor on Aurora A kinase and the G2/M phase pathway in hematopoietic stem and progenitor cells

  2022cites this paper
• Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression

  2022cites this paper
• The Aryl Hydrocarbon Receptor Modulates Murine Hematopoietic Stem Cell Homeostasis and Influences Lineage-Biased Stem and Progenitor Cells

  2021cites this paper
• 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality

  2021cites this paper
• Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis

  2020cites this paper
• Erythropoiesis and Megakaryopoiesis in a Dish Erythropoiesis and Megakaryopoiesis in a Dish

  2019cites this paper
• Immunotoxicology of Halogenated Aromatic Hydrocarbons

  2018cites this paper
• Environmental cues received during development shape dendritic cell responses later in life

  2018cites this paper
• Aryl-Hydrocarbon Receptor as a Potential Target for Anticancer Therapy

  2018cites this paper
• The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation

  2018cites this paper
• Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome

  2018cites this paper
• Chemistry and Properties of Indolocarbazoles.

  2018cites this paper
• Erythropoiesis and Megakaryopoiesis in a Dish

  2018cites this paper
• Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells

  2018cites this paper
• Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease.

  2017cites this paper
• Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target

  2017cites this paper
• Environmental Factors Impacting Bone-Relevant Chemokines

  2017influential citation
• Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure.

  2017cites this paper
• Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

  2017cites this paper
• Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients.

  2017cites this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) role in hematopoiesis and in hematologic diseases: A critical review.

  2016cites this paper
• Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4‐nitroquinoline‐1‐oxide

  2016cites this paper
• Evaluation of Toxicity in Mouse Bone Marrow Progenitor Cells

  2016cites this paper
• An investigation of the pharmacogenetic basis of toxicity to platinum chemotherapy agents

  2016cites this paper
• An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER−/PR−/Her2− Human Breast Cancer Cells

  2016cites this paper
• Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells

  2016cites this paper
• Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells

  2015cites this paper
• Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells

  2015cites this paper
• Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality*

  2015cites this paper
• Effects of polychlorinated biphenyls (PCBs) on telomere maintenance in hematopoietic stem cells and progenitor cells

  2015cites this paper
• The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment

  2014cites this paper
• Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates capacity of hematopoietic stem cells to undergo lymphocyte differentiation.

  2014cites this paper
• AhR (Aryl Hydrocarbon Receptor) Polymorphisms: A Possible Role in TCDD (Dioxins)-AhR Binding and Carcinogenesis

  2014cites this paper
• Impact of Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin on T Lymphocyte Development

  2014cites this paper
• The Role of Indoleamine 2,3 Dioxygenase in Beneficial Effects of Stem Cells in Hind Limb Ischemia Reperfusion Injury

  2014cites this paper
• The Ah receptor in stem cell cycling, regulation, and quiescence

  2014cites this paper
• Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice

  2014influential citation
• Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration

  2014cites this paper
• The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment

  2014cites this paper
• T-cell potential of human adult and cord blood hemopoietic stem cells expanded with the use of aryl hydrocarbon receptor antagonists.

  2013cites this paper
• The roles of aryl hydrocarbon receptor in immune responses.

  2013cites this paper
• The role of DNA methylation in stem cell ageing

  2013cites this paper
• Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification

  2013cites this paper
• The role of the aryl hydrocarbon receptor in normal and malignant B cell development

  2013influential citation
• Dioxin Receptor Expression Inhibits Basal and Transforming Growth Factor β-induced Epithelial-to-mesenchymal Transition*

  2013cites this paper
• Methylomic analysis identifies the involvement of migration and adhesion genes in the ageing of primary haematopoietic stem cells

  2013influential citation
• Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of Tregs and stem cells.

  2012cites this paper
• Sustainability in Software Engineering: A Systematic Literature Review for Building up a Knowledge Base

  2012cites this paper
• Integrative and Translational Physiology : Inflammation and Immunity in Organ System Physiology Aryl hydrocarbon receptor agonist , leflunomide , protects the ischemic-reperfused kidney : role of Tregs and stem cells

  2012cites this paper
• Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation.

  2012cites this paper
• Biology and function of the aryl hydrocarbon receptor: report of an international and interdisciplinary conference

  2012cites this paper