Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Endocrinology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 17478551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2003cited by this paper
• Paracrine control of lactotrope proliferation and differentiation.

  2003cited by this paper
• Consequences of targeted inactivation of LH receptors.

  2002cited by this paper
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  2002cited by this paper
• Defining the actions of transforming growth factor beta in reproduction

  2002cited by this paper
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  2002cited by this paper
• Semen collection from mice: electroejaculation.

  2002cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Estrogen-Astrocyte-Luteinizing Hormone-Releasing Hormone Signaling: A Rolefor Transforming Growth Factor-β11

  2000cited by this paper
• Genetic control of the circulating concentration of transforming growth factor type beta1.

  1999cited by this paper
• Autocrine regulation of Leydig cell differentiated functions by insulin-like growth factor I and transforming growth factor beta.

  1999cited by this paper
• Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

  1999cited by this paper
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  1999cited by this paper
• Leptin's actions on the reproductive axis: perspectives and mechanisms.

  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• Transforming growth factor beta1 inhibits steroidogenesis in dispersed fetal testicular cells in culture.

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Expression of mRNAs for transforming growth factor-beta receptors in the rat testis.

  1995cited by this paper
• Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

  1995cited by this paper
• Physiology of penile erection.

  1995cited by this paper
• Somatic cell-germ cell relationships in mammalian testes during development and spermatogenesis.

  1994cited by this paper
• Maternal rescue of transforming growth factor-beta 1 null mice.

  1994cited by this paper
• Transforming growth factor-beta (beta 1, beta 2, and beta 3) gene expression and action during pubertal development of the seminiferous tubule: potential role at the onset of spermatogenesis.

  1993cited by this paper
• Localization of transforming growth factor beta 1 and beta 2 during testicular development in the rat.

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Reversal of reproductive deficiency in the hpg male mouse by neonatal androgenization.

  1992cited by this paper
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  1991cited by this paper
• Cell lineage specificity of expression of the murine transforming growth factor beta 3 and transforming growth factor beta 1 genes.

  1991cited by this paper
• Direct regulating effects of transforming growth factor beta on the Leydig cell steroidogenesis in primary culture.

  1988cited by this paper
• Transforming growth factor-beta inhibits Leydig cell steroidogenesis in primary culture.

  1987cited by this paper
• Transforming growth factor beta inhibits Leydig cell functions.

  1987cited by this paper
• Differential effects of food restriction on pituitary-testicular function in mice.

  1985cited by this paper
• Endocrine responses to sexual arousal in male mice.

  1982cited by this paper
• Ejaculatory reflex and luteal activity induction in Mus musculus.

  1970cited by this paper
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  1956cited by this paper

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  2025cites this paper
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