Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Microbiology

• Publication date

  2014-12-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/mmi.12892PMID 25430994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of rpsA Gene Sequencing in Diagnosis of Pyrazinamide Resistance

  2013cited by this paper
• Role of pncA and rpsA Gene Sequencing in Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from Southern China

  2013cited by this paper
• Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA

  2012cited by this paper
• Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

  2011influential reference
• SmpB as the handyman of tmRNA during trans-translation

  2011cited by this paper
• Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels

  2011cited by this paper
• The S1 ribosomal protein family contains a unique conservative domain

  2010cited by this paper
• Probing the relationship between Gram-negative and Gram-positive S1 proteins by sequence analysis

  2009influential reference
• S1 Ribosomal Protein Functions in Translation Initiation and Ribonuclease RegB Activation Are Mediated by Similar RNA-Protein Interactions

  2008cited by this paper
• Biology of trans-translation.

  2008cited by this paper
• In vitro trans-translation of Thermus thermophilus: ribosomal protein S1 is not required for the early stage of trans-translation.

  2007cited by this paper
• Ribosomal protein S1 is not essential for the trans-translation machinery.

  2007cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.

  2004cited by this paper
• Multiple sequence alignment with the Clustal series of programs

  2003cited by this paper
• Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid.

  2003cited by this paper
• Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I

  2002cited by this paper
• Mycobacterium smegmatis Has Two Pyrazinamidase Enzymes, PncA and PzaA

  2000cited by this paper
• Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis

  2000cited by this paper
• Binding and cross‐linking of tmRNA to ribosomal protein S1, on and off the Escherichia coli ribosome

  2000cited by this paper
• ESPript: analysis of multiple sequence alignments in PostScript

  1999cited by this paper
• Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

  1999influential reference
• Purification, Gene Cloning, Targeted Knockout, Overexpression, and Biochemical Characterization of the Major Pyrazinamidase fromMycobacterium smegmatis

  1998cited by this paper
• Ribosomal protein S1 is required for translation of most, if not all, natural mRNAs in Escherichia coli in vivo.

  1998cited by this paper
• Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold.

  1997influential reference
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

  1996cited by this paper
• LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.

  1995cited by this paper
• NMRPipe: A multidimensional spectral processing system based on UNIX pipes

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• OB(oligonucleotide/oligosaccharide binding)‐fold: common structural and functional solution for non‐homologous sequences.

  1993influential reference
• The action of antituberculosis drugs in short-course chemotherapy.

  1985cited by this paper
• Structure and functions of ribosomal protein S1.

  1983cited by this paper
• Activation of pyrazinamide and nicotinamide in acidic environments in vitro.

  1954cited by this paper
• Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination

  year unknowncited by this paper

• Bacterial ribosome heterogeneity facilitates rapid response to stress

  2025cites this paper
• Differential scanning fluorimetry followed by microscale thermophoresis and/or isothermal titration calorimetry as an efficient tool for ligand screening

  2025cites this paper
• Tinjauan Literatur tentang Hubungan Mutasi Genetik dengan Resistensi Obat pada Mycobacterium Tuberculosis

  2024cites this paper
• In silico identification of phytochemical inhibitors for multidrug-resistant tuberculosis based on novel pharmacophore generation and molecular dynamics simulation studies

  2024cites this paper
• Extraribosomal Functions of Bacterial Ribosomal Proteins—An Update, 2023

  2024cites this paper
• Free energy landscape and thermodynamics properties of novel mutations in PncA of pyrazinamide resistance isolates of Mycobacterium tuberculosis

  2023cites this paper
• Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update

  2022cites this paper
• Pyrazinamide Analogs Designed for Rational Drug Designing Strategies against Resistant Tuberculosis

  2022cites this paper
• Activity of Pyrazinamide against Mycobacterium tuberculosis at Neutral pH in PZA-S1 Minimal Medium

  2021cites this paper
• In Silico Drug Designing for ala438 Deleted Ribosomal Protein S1 (RpsA) on the Basis of the Active Compound Zrl15

  2021cites this paper
• Trans-Translation Is an Appealing Target for the Development of New Antimicrobial Compounds

  2021cites this paper
• Silencing of an efflux pump coding gene decreases the efflux rate of pyrazinoic acid in Mycobacterium smegmatis

  2021cites this paper
• Target related in silico analysis of Bergenin and tuberculosis management

  2021cites this paper
• Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD+/NADH dysregulation.

  2020cites this paper
• Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies.

  2020cites this paper
• Mechanistic analysis of A46V, H57Y, and D129N in pyrazinamidase associated with pyrazinamide resistance

  2020cites this paper
• A new sulphur containing heterocycles having azo linkage: Synthesis, structural characterization and biological evaluation

  2020cites this paper
• Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid

  2020cites this paper
• Discovery and evaluation of new compounds targeting ribosomal protein S1 in antibiotic-resistant Mycobacterium Tuberculosis.

  2020cites this paper
• EXPRESSION OF Mycobacterium tuberculosis RpsA IN Mycobacterium smegmatis INCREASES SUSCEPTIBILITY TO PYRAZINAMIDE

  2020cites this paper
• Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance

  2020cites this paper
• A Comprehensive Review onMycobacterium tuberculosisTargets and Drug Development from a Structural Perspective

  2020cites this paper
• Development of DNA vaccines encoding ribosomal proteins (RplL and RpsA) against Nocardia seriolae infection in fish.

  2019cites this paper
• Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.

  2019influential citation
• Exploring the Pyrazinamide Drug Resistance Mechanism of Clinical Mutants T370P and W403G in Ribosomal Protein S1 ofMycobacterium tuberculosis

  2019cites this paper
• Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide

  2019cites this paper
• Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity

  2019cites this paper
• Synthesis, characterization, pharmacological and computational studies of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole incorporated azo dyes

  2019cites this paper
• Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance

  2019cites this paper
• Solution structure and backbone dynamics for S1 domain of ribosomal protein S1 from Mycobacterium tuberculosis

  2019cites this paper
• Introducing RpsA Point Mutation Δ438A or D123A into the Chromosome of M. tuberculosis Confirms its Role in Causing Resistance to Pyrazinamide

  2019cites this paper
• Marine Natural Products and Drug Resistance in Latent Tuberculosis

  2019cites this paper
• Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in Mycobacterium tuberculosis by Competing with tmRNA

  2019influential citation
• Structural Dynamics Behind Clinical Mutants of PncA-Asp12Ala, Pro54Leu, and His57Pro of Mycobacterium tuberculosis Associated With Pyrazinamide Resistance

  2019cites this paper
• Molecular Basis of Drug Resistance in Mycobacteria

  2019cites this paper
• Insights into the Mechanisms of the Pyrazinamide Resistance of Three Pyrazinamidase Mutants N11K, P69T, and D126N.

  2018cites this paper
• Design, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffold.

  2018cites this paper
• Pyrazinamide drug resistance in RpsA mutant (∆438A) of Mycobacterium tuberculosis: Dynamics of essential motions and free‐energy landscape analysis

  2018cites this paper
• Insight into novel clinical mutants of RpsA-S324F, E325K, and G341R of Mycobacterium tuberculosis associated with pyrazinamide resistance

  2018influential citation
• Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents

  2018cites this paper
• Expression, purification and characterization of the full-length SmpB protein from Mycobacterium tuberculosis.

  2018cites this paper
• Pyrazinamide resistance and mutations L19R, R140H, and E144K in Pyrazinamidase of Mycobacterium tuberculosis

  2018cites this paper
• Identification of Novel Efflux Proteins Rv0191, Rv3756c, Rv3008, and Rv1667c Involved in Pyrazinamide Resistance in Mycobacterium tuberculosis

  2017cites this paper
• New antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001–2016)

  2017cites this paper
• Chemical shift assignments of Ribosomal protein S1 from Mycobacterium tuberculosis

  2017influential citation
• The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot

  2017influential citation
• Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

  2017cites this paper
• Structural basis for ribosome protein S1 interaction with RNA in trans-translation of Mycobacterium tuberculosis.

  2017cites this paper
• Backbone and side-chain resonance assignments for the tmRNA-binding protein, SmpB, from Mycobacterium tuberculosis

  2017cites this paper
• Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

  2017cites this paper
• Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation

  2017cites this paper
• Synthesis, antibacterial and antitubercular activity of novel Schiff bases of 2-(1-benzofuran-2-yl)quinoline-4-carboxylic acid derivatives

  2017cites this paper
• Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance

  2017cites this paper
• Backbone and side-chain resonance assignments for the tmRNA-binding protein, SmpB, from Mycobacterium tuberculosis

  2017cites this paper
• Evolution of Phenotypic and Molecular Drug Susceptibility Testing.

  2017cites this paper
• Identification of M. tuberculosis pncA gene single nucleotide polymorphisms conferring resistance to pyrazinamide.

  2016cites this paper
• Antibiotic resistance mechanisms in M. tuberculosis: an update

  2016influential citation
• 1H, 15N, 13C resonance assignments for pyrazinoic acid binding domain of ribosomal protein S1 from Mycobacterium tuberculosis

  2016cites this paper
• Non-canonical transcription initiation: the expanding universe of transcription initiating substrates.

  2016cites this paper
• Studies on the stress responses of M. tuberculosis : tmRNA and α-crystallins.

  2016cites this paper
• A microfluidics system for drug susceptibility testing in mycobacterium smegmatis.

  2015cites this paper
• Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite?

  2015cites this paper
• Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides.

  2015cites this paper
• Design, synthesis and anti-mycobacterial evaluation of some new N-phenylpyrazine-2-carboxamides

  2015cites this paper
• Pyrazinamide: the importance of uncovering the mechanisms of action in mycobacteria

  2015cites this paper