Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Psychopharmacology

• Publication date

  2009-07-08

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s00213-009-1595-3PMID 19585107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998influential reference
• In vivo detection of short‐ and long‐term MDMA neurotoxicity—a positron emission tomography study in the living baboon brain

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  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Persistent effects of (+/- )3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on human sleep.

  1993influential reference
• Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.

  1993cited by this paper
• Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate.

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Acute tryptophan depletion: a method of studying antidepressant action.

  1992cited by this paper
• Neurotoxic Amphetamine Analogues: Effects in Monkeys and Implications for Humans a

  1992cited by this paper
• Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat.

  1990cited by this paper
• Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats.

  1989cited by this paper
• The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.

  1989cited by this paper
• 3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.

  1989cited by this paper
• Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals.

  1985cited by this paper
• Modulation of brain tryptophan hydroxylase activity by brain tryptophan content.

  1977cited by this paper
• Dorsal raphe neurons: depression of firing during sleep in cats.

  1976cited by this paper
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