The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration

A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8+ T cells located in the proximity of malignant lesions are associated with a survival advantage, suggesting the existence of immunoediting. Pancreatic stellate cells appear to dictate the infiltration of the juxtatumoral stroma by CD8+ T cells.

• Publication year

  2013

• Venue

  Oncoimmunology

• Publication date

  2013-10-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/onci.26788PMID 24498555PMCID 3912010
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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