Comparison of topical application of oxytetracycline and four nonantibiotic solutions for treatment of papillomatous digital dermatitis in dairy cows.

OBJECTIVE To compare efficacy of topical treatment with oxytetracycline solution or 1 of 4 nonantibiotic solutions among dairy cows with papillomatous digital dermatitis (PDD). DESIGN Randomized field trial. ANIMALS 66 cows in a single herd. PROCEDURE Cows were randomly assigned to be treated with oxytetracycline solution; a commercial formulation of soluble copper, peroxide compound, and a cationic agent; 5% copper sulfate solution; acidified ionized copper solution; hydrogen peroxide-peroxyacetic acid solution; or tap water. Cows were examined 14 and 30 days after initial treatment. During each examination, pain and lesion scores were recorded. RESULTS On the basis of pain and lesion scores, oxytetracycline and the commercial formulation appeared equally effective for treatment of PDD and significantly more effective than 5% copper sulfate solution, acidified ionized copper solution, hydrogen peroxide-peroxyacetic acid solution, and tap water. Proportions of cows with signs of pain or visible lesions after treatment were significantly lower for cows treated with oxytetracycline or the commercial formulation than for cows in the other groups. CLINICAL IMPLICATIONS Oxytetracycline and a commercial formulation of soluble copper, peroxide compound, and a cationic agent appeared to be effective for treatment of PDD in dairy cows.

• Publication year

  1999

• Venue

  Journal of the American Veterinary Medical Association

• Publication date

  1999-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2460/javma.1999.214.05.688PMID 10088020
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Papillomatous Digital Dermatitis (Footwarts) in California Dairy Cattle: Clinical and Gross Pathologic Findings

  1998cited by this paper
• Papillomatous digital dermatitis on a commercial dairy farm in Mexicali, Mexico: incidence and effect on reproduction and milk production.

  1997cited by this paper
• Papillomatous digital dermatitis in 458 dairies.

  1996cited by this paper
• Comparison of topical application of three products for treatment of papillomatous digital dermatitis in dairy cattle.

  1996cited by this paper
• Observations on the pathogenesis of digital dermatitis in cattle

  1994cited by this paper
• An invasive spirochaete associated with interdigital papillomatosis of dairy cattle

  1992cited by this paper

• Evaluation of the use of a copper and zinc chelate in the treatment of cows affected by digital dermatitis

  2025cites this paper
• Benchmarking analysis of computer vision algorithms on edge devices for the real-time detection of digital dermatitis in dairy cows.

  2024cites this paper
• Comparative efficacy of stannous fluoride and copper sulfate footbath solutions for the treatment and prevention of digital dermatitis in lactating dairy cows.

  2024cites this paper
• Multilocus sequence typing of pathogenic treponemes isolated from contagious ovine digital dermatitis stage five lesions: Implications for disease transmission dynamics.

  2024cites this paper
• A review of foot-related lameness in feedlot cattle

  2024cites this paper
• Dairy cattle lameness prevalence, causes and risk factors in selected farms of southern Ethiopia

  2021cites this paper
• Approaches to the Treatment of Diseases of Distal Limb Parts in Cattle

  2021cites this paper
• Clinico-pathological alterations in Holstein dairy cows with digital dermatitis with therapeutic intervention

  2020cites this paper
• Efficacy of non-antibiotic treatment options for digital dermatitis on an organic dairy farm.

  2020cites this paper
• Comparison of effects of routine topical treatments in the milking parlor on digital dermatitis lesions.

  2018cites this paper
• Efficacy of a commercial glutaraldehyde footbath product for the control of bovine digital dermatitis

  2018cites this paper
• Lameness in Cattle

  2017cites this paper
• APPLICABILITY OF ASSISTED REPRODUCTION TECHNIQUES IN CONTEMPORARY SMALL RUMINANT FARMING

  2017cites this paper
• Effectiveness of collective treatments in the prevention and treatment of bovine digital dermatitis lesions: A systematic review.

  2017cites this paper
• COINFECTION OF CHICKEN ANAEMIA VIRUS, MYCOPLASMA GALLISEPTICUM, AVIAN METAPNEUMOVIRUS AND AVIAN REOVIRUS IN FANCY CHICKEN BREEDS

  2017influential citation
• Estimating the true prevalence of bovine digital dermatitis in taranaki, New Zealand using a bayesian latent class model.

  2017cites this paper
• Identifying infection reservoirs of digital dermatitis in dairy cattle

  2017cites this paper
• Honey and Medicinal Plants in the Management of Certain Surgical Bovine Clow Affections

  2017cites this paper
• Effectiveness of the gel containing chelated copper and zinc for treating digital dermatitis in dairy cows.

  2017influential citation
• Producer estimates of prevalence and perceived importance of lameness in dairy herds with tiestalls, freestalls, and automated milking systems.

  2017cites this paper
• Efficacy of Digital Dermatitis treatment with non-antibiotic Hoof-Sol spray in dairy cattle

  2016cites this paper
• Effectiveness of salicylic acid paste for treatment of digital dermatitis in dairy cows compared with tetracycline spray and hydrotherapy.

  2015cites this paper
• Clinical evidence for individual animal therapy for papillomatous digital dermatitis (hairy heel wart) and infectious bovine pododermatitis (foot rot).

  2015cites this paper
• Presence and Treatment of Digital Dermatitis Lesions in Dairy Cattle

  2014cites this paper
• Efficacy of salicylic acid in the treatment of digital dermatitis in dairy cattle.

  2013cites this paper
• Infectious diseases causing lameness in cattle with a main emphasis on digital dermatitis (Mortellaro disease)

  2013cites this paper
• Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle.

  2013cites this paper
• Farmers' practices, motivators and barriers for adoption of treatments of digital dermatitis in dairy farms.

  2013cites this paper
• Welfare in dairy cattle: Epidemiologic approaches for detection and treatment of lameness

  2012cites this paper
• The effect of an acidified, ionized copper sulphate solution on digital dermatitis in dairy cows.

  2012cites this paper
• Einfluss einer Klauenwaschanlage auf die Klauengesundheit einer Milchviehherde

  2012cites this paper
• Efficiency of different therapeutic protocols in treating digital dermatitis in dairy cows.

  2012cites this paper
• A field evaluation of a footbathing solution for the control of digital dermatitis in cattle.

  2012cites this paper
• Diseases of Dairy Animals | Infectious Diseases: Hairy Heel Warts

  2011cites this paper
• Comparação entre as administrações tópica e sistêmica de oxitetraciclina no tratamento de vacas com dermatite digital papilomatosa

  2010cites this paper
• Antimicrobial susceptibility of Treponema phagedenis-like spirochetes isolated from dairy cattle with papillomatous digital dermatitis lesions in Japan.

  2010cites this paper
• Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis.

  2010cites this paper
• Prevalence of digital dermatitis in first lactation cows assessed at breeding cattle auctions.

  2010cites this paper
• Efficacy of formalin, copper sulfate, and a commercial footbath product in the control of digital dermatitis.

  2010influential citation
• Herd-level risk factors for seven different foot lesions in Ontario Holstein cattle housed in tie stalls or free stalls.

  2009cites this paper
• Genetic Heterogeneity among Strains of Treponema phagedenis-Like Spirochetes Isolated from Dairy Cattle with Papillomatous Digital Dermatitis in Japan

  2009cites this paper
• Peripheral blood leukocyte subpopulation of dairy cows with digital dermatitis and effect of hoof trimming with antibiotic treatment.

  2009cites this paper
• CHAPTER 52 – Infectious Disorders of the Foot Skin

  2009cites this paper
• Healing of digital dermatitis after a single treatment with topical oxytetracycline in 89 dairy cows

  2008cites this paper
• Effects of different intervention strategies on the incidence of papillomatous digital dermatitis in dairy cows

  2008cites this paper
• Evaluation of the efficacy of prophylactic hoof health examination and trimming during midlactation in reducing the incidence of lameness during late lactation in dairy cows.

  2007cites this paper
• Clinical assessment of four individual treatment for digital dermatitis in dairy cows.

  2007cites this paper
• Manual for Treatment and Control of Lameness in Cattle

  2006cites this paper
• Treatment strategies for digital dermatitis for the UK.

  2006cites this paper
• Comparison of the calving-to-conception interval in dairy cows with different degrees of lameness during the prebreeding postpartum period.

  2005cites this paper
• Efficacy of the non-antibiotic paste Protexin Hoof-Care for topical treatment of digital dermatitis in dairy cows.

  2004cites this paper
• Effect of lameness on ovarian activity in postpartum holstein cows.

  2004cites this paper
• Managing the Metabolism of Transition Cows

  2003cites this paper
• From tooth to hoof: treponemes in tissue-destructive diseases.

  2003cites this paper
• Managing Lameness for Improved Cow Comfort and Performance

  2003cites this paper
• Characterization of the predominant anaerobic bacterium recovered from digital dermatitis lesions in three Michigan dairy cows.

  2003cites this paper
• Topical treatment of digital dermatitis associated with severe heel-horn erosion in a Swedish dairy herd.

  2002cites this paper
• Effect of lameness on milk yield in dairy cows.

  2002cites this paper
• DISEASES OF DAIRY ANIMALS, INFECTIOUS | Hairy Heel Warts

  2002cites this paper
• Überprüfung der Wirksamkeit stallspezifischer Vakzinen zur Bekämpfung der Dermatitis digitalis bei Milchkühen

  2001cites this paper
• Efficacy of a nonantimicrobial cream administered topically for treatment of digital dermatitis in dairy cattle.

  2001cites this paper
• Antimicrobial issues in bovine lameness.

  2001cites this paper
• Effect of lameness on the calving-to-conception interval in dairy cows.

  2001cites this paper
• Ulcerative and papillomatous digital dermatitis of the pastern region in dairy cattle: clinical and histopathological studies.

  2001cites this paper
• Diseases of the digital soft tissues.

  2001cites this paper
• Efficacy of two modified nonantibiotic formulations (Victory) for treatment of papillomatous digital dermatitis in dairy cows.

  2000cites this paper
• Efficacy of oxytetracycline for treatment of papillomatous digital dermatitis lesions on various anatomic locations in dairy cows.

  2000cites this paper
• Digital Dermatitis : New Ideas on an Old Disease

  year unknowncites this paper