A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)

BackgroundThe androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic.MethodsTo determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism.ResultsWe found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples.ConclusionsOur results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted.

• Publication year

  2015

• Venue

  BMC Genetics

• Publication date

  2015-10-26

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1186/s12863-015-0284-yPMID 26503624PMCID 4623281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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