Androgen metabolism in hirsute patients treated with cyproterone acetate.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Journal of Steroid Biochemistry

• Publication date

  1984-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0022-4731(84)90081-5PMID 6231428
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex-specific action of antiandrogens on androgen induced changes in hepatic microsomal 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity in the rat.

  1981cited by this paper
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  1981cited by this paper
• Treatment of hirsutism by oral cyproterone acetate and percutaneous estradiol.

  1980cited by this paper
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  1979cited by this paper
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• [Deviation in cortisol metabolism induced by rifampicin. Therapeutic consequences in adrenal failure (author's transl)].

  1979cited by this paper
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  1978cited by this paper
• Urinary 5 alpha-androstane-3 alpha,17 beta-diol radioimmunoassay: a new clinical evaluation.

  1978cited by this paper
• Effect of the Tfm locus on the hepatic ethylmorphine N-demethylase system in mice.

  1978cited by this paper
• The additive effects of progestins on testosterone-stimulated hepatic ethylmorphine metabolism and cytochrome P-450 content.

  1977cited by this paper
• Androgen production and skin metabolism in hirsutism.

  1977cited by this paper
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  1977cited by this paper
• Induction of hepatic microsomal enzymes after brief administration of rifampicin in man.

  1977cited by this paper
• Treatment of hirsutism and acne in women with two combinations of cyproterone acetate and ethinylestradiol.

  1976cited by this paper
• Testosterone 5alpha-reduction in the skin of normal subjects and of patients with abnormal sex development.

  1975cited by this paper
• Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilism.

  1975cited by this paper
• Evidence for a specific dihydrotestosterone-binding cytosol receptor in the human prostate.

  1975cited by this paper
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  1975cited by this paper
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  1974cited by this paper
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  1974cited by this paper
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  1974cited by this paper
• On the mechanism of the anti-androgenic effect of medroxyprogesterone acetate.

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  1973cited by this paper
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  1972cited by this paper
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  1971cited by this paper
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  1970cited by this paper
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  1970cited by this paper
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  2024cites this paper
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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2015cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2000influential citation
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  1990cites this paper
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  1986cites this paper
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  1986cites this paper
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