Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Archives of Biochemistry and Biophysics

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0003-9861(87)90039-7PMID 3813540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents.

  1986cited by this paper
• Interaction of cytochrome P-450 with a hydroperoxide derived from butylated hydroxytoluene. Mechanism of isomerization.

  1985cited by this paper
• Endogenous release of hepoxilin A3 from isolated perifused pancreatic islets of Langerhans.

  1985cited by this paper
• Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.

  1985cited by this paper
• Imidazole antimycotics: inhibitors of steroid aromatase.

  1985cited by this paper
• Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.

  1985cited by this paper
• Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver.

  1984cited by this paper
• The mechanistic plurality of cytochrome P-450 and its biological ramifications.

  1984cited by this paper
• Hepoxilin, a new family of insulin secretagogues formed by intact rat pancreatic islets.

  1984cited by this paper
• Hepoxilin A, hydroxyepoxide metabolite of arachidonic acid, stimulates transport of 45Ca across the guinea pig visceral yolk sac.

  1984cited by this paper
• Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450

  1984cited by this paper
• Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen. A proposed method for P-450 kinetic studies.

  1983cited by this paper
• The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase.

  1983cited by this paper
• Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

  1983cited by this paper
• Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid.

  1982cited by this paper
• The oxidative metabolism of arachidonic acid by purified cytochromes P-450.

  1981cited by this paper
• Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

  1981cited by this paper
• Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties.

  1981cited by this paper
• Leukotrienes: a major step in the understanding of immediate hypersensitivity reactions.

  1981cited by this paper
• Preparation and assay of monohydroxy-eicosatetraenoic acids.

  1980cited by this paper
• The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

  1979cited by this paper
• Preparation and purification of arachidonic acid hydroperoxides of biological importance

  1979cited by this paper
• THE ROLE OF SUPEROXIDE AND SINGLET OXYGEN IN LIPID PEROXIDATION

  1978cited by this paper
• Preparation and purification of lipid hydroperoxides from arachidonic and gamma-linolenic acids.

  1976cited by this paper
• Methods in Enzymology , Vol

  1966cited by this paper
• THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

  1964cited by this paper
• Determination of serum proteins by means of the biuret reaction.

  1949cited by this paper

• Oxygen Surrogate Systems for Supporting Human Drug-Metabolizing Cytochrome P450 Enzymes

  2020cites this paper
• Formation and Cleavage of C-C Bonds by Enzymatic Oxidation-Reduction Reactions.

  2018cites this paper
• Regio- and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis-Epoxides

  2015cites this paper
• Monooxygenase, peroxidase and peroxygenase properties and reaction mechanisms of cytochrome P450 enzymes.

  2015cites this paper
• Functional annotation of orphan human P450 enzymes: Heterologous expression and substrate searches by metabolomic approaches

  2014cites this paper
• Hypoxia activates 15‐PGDH and its metabolite 15‐KETE to promote pulmonary artery endothelial cells proliferation via ERK1/2 signalling

  2014cites this paper
• The monooxygenase, peroxidase, and peroxygenase properties of cytochrome P450.

  2012cites this paper
• Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.

  2011cites this paper
• Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase

  2011cites this paper
• Cytochrome P 450 2 S 1 is Reduced by NADPH-Cytochrome P 450 Reductase

  2011cites this paper
• Human CYP2S1 Metabolizes Cyclooxygenase- and Lipoxygenase-Derived Eicosanoids

  2011cites this paper
• Cytochrome P450 Enzymes

  2010cites this paper
• Identification of 13-Hydroxy-14,15-epoxyeicosatrienoic Acid as an Acid-stable Endothelium-derived Hyperpolarizing Factor in Rabbit Arteries*

  2009cites this paper
• Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.

  2007cites this paper
• Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids

  2005cites this paper
• Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.

  2004cites this paper
• Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta.

  2003cites this paper
• Transcriptional regulation of 12/15-lipoxygenase expression and the implication of the enzyme in hepoxilin biosynthesis and apoptosis

  2003cites this paper
• Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.

  2003cites this paper
• Microsomal cytochrome P450 and eicosanoid metabolism.

  2002cites this paper
• Microsomal cytochrome P450 and eicosanoid metabolism

  2002cites this paper
• Comparisons of hydroperoxide isomerase and monooxygenase activities of cytochrome P450 for conversions of allylic hydroperoxides and alcohols to epoxyalcohols and diols: probing substrate reorientation in the active site.

  2001cites this paper
• Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.

  2000cites this paper
• Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase.

  2000cites this paper
• Human cytochromes P450

  1999cites this paper
• Identification of the 11,14,15- and 11,12,15-Trihydroxyeicosatrienoic Acids as Endothelium-derived Relaxing Factors of Rabbit Aorta*

  1998cites this paper
• Enantioselective conversion of linoleate hydroperoxide to an α, β-epoxy alcohol by niobium ethoxide

  1998cites this paper
• Antioxidant properties of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone).

  1998cites this paper
• Glucuronic Acid-conjugated Dihydroxy Fatty Acids in the Urine of Patients with Generalized Peroxisomal Disorders (*)

  1996cites this paper
• Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products.

  1996cites this paper
• Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450

  1996cites this paper
• Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver.

  1996cites this paper
• Structure-function features of flaxseed allene oxide synthase.

  1995cites this paper
• Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids

  1995cites this paper
• Novel Transformations of HPETEs by Cytochrome P45Os a

  1994cites this paper
• Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.

  1994cites this paper
• Formation of epoxyalcohols by a purified allene oxide synthase. Implications for the mechanism of allene oxide synthesis.

  1993cites this paper
• Polyunsaturated fatty acid alkoxyl radicals exist as carbon-centered epoxyallylic radicals: a key step in hydroperoxide-amplified lipid peroxidation.

  1993cites this paper
• Cytochrome P-450 under conditions of oxidative stress: role of antioxidant recycling in the protection mechanisms.

  1992cites this paper
• NADPH-Supported and arachidonic acid-supported metabolism of the enantiomers of /raw5-7,8-dih ydrobenzo(a)pyrene-7,8-dioI by human liver microsomal samples

  1992cites this paper
• Bacterial metabolism of human polymorphonuclear leukocyte-derived arachidonic acid

  1992cites this paper
• Phospholipase A2 and signal transduction.

  1992cites this paper
• NADPH-supported and arachidonic acid-supported metabolism of the enantiomers of trans-7,8-dihydrobenzo[a]pyrene-7,8-diol by human liver microsomal samples.

  1992cites this paper
• [Biosynthetic paths of acyclic lipoxygenase metabolites of polyenic acids].

  1991cites this paper
• THE CYTOCHROME P450s AND OXYGEN STRESS

  1991cites this paper
• Transformation of arachidonic acid by 5- and 15-lipoxygenase pathways in bovine adrenal fasciculata cells.

  1990cites this paper
• Cytochrome P-450 arachidonate oxygenase.

  1990cites this paper
• Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling.

  1990cites this paper
• Possible involvement of arachidonic acid metabolites of cytochrome P450 monooxygenase pathway in vasopressin-stimulated glycogenolysis in isolated rat hepatocytes.

  1990cites this paper
• Role of eicosanoids in mammalian skin epidermis.

  1990cites this paper
• Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid.

  1989cites this paper
• Purification and characterization of an anticonvulsant-induced human cytochrome P-450 catalysing cyclosporin metabolism.

  1989cites this paper
• Products of heme-catalyzed transformation of the arachidonate derivative 12-HPETE open S-type K+ channels in Aplysia.

  1989cites this paper
• Eicosanoids in the fetal and transitional pulmonary circulation.

  1988cites this paper
• Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.

  1988cites this paper
• Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase.

  1988cites this paper