Mammalian target of rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpgi.00047.2010PMID 21252047
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids.

  2010cited by this paper
• Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3)

  2010cited by this paper
• Enhancing mTOR-targeted cancer therapy

  2009cited by this paper
• The TOR pathway comes of age.

  2009cited by this paper
• Kupffer cells mediate leptin-induced liver fibrosis.

  2009cited by this paper
• Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

  2009cited by this paper
• LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

  2009cited by this paper
• Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

  2009cited by this paper
• Adipokines in liver diseases

  2009cited by this paper
• Angiogenesis and liver fibrogenesis.

  2009cited by this paper
• AMPK in Health and Disease.

  2009cited by this paper
• Angiogenesis in liver disease.

  2009cited by this paper
• Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein.

  2009cited by this paper
• Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells

  2008influential reference
• Fibrogenesis of parenchymal organs.

  2008cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2008cited by this paper
• Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors

  2008cited by this paper
• High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate–activated protein kinase

  2008cited by this paper
• Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.

  2008cited by this paper
• Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells.

  2008cited by this paper
• Protein Tyrosine Phosphorylation and Reversible Oxidation: Two Cross-Talking Posttranslation Modifications

  2007cited by this paper
• Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats

  2007cited by this paper
• Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma.

  2007cited by this paper
• Leptin and liver tissue repair: do rodent models provide the answers?

  2007cited by this paper
• Adenosine monophosphate–activated protein kinase modulates the activated phenotype of hepatic stellate cells

  2007cited by this paper
• Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells.

  2007cited by this paper
• NADPH oxidase in the liver: defensive, offensive, or fibrogenic?

  2006cited by this paper
• mTOR and cancer: insights into a complex relationship

  2006cited by this paper
• TOR signaling in growth and metabolism.

  2006cited by this paper
• Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway.

  2006cited by this paper
• Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

  2006cited by this paper
• TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.

  2006cited by this paper
• Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

  2006cited by this paper
• Hypothalamic mTOR Signaling Regulates Food Intake

  2006cited by this paper
• Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells

  2005cited by this paper
• Long-Term Treatment of Bile Duct-Ligated Rats with Rapamycin (Sirolimus) Significantly Attenuates Liver Fibrosis: Analysis of the Underlying Mechanisms

  2005cited by this paper
• Angiogenesis in life, disease and medicine

  2005cited by this paper
• Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation

  2004cited by this paper
• Leptin signaling.

  2004cited by this paper
• Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.

  2004cited by this paper
• Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells

  2004cited by this paper
• Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

  2004cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• TSC2 mediates cellular energy response to control cell growth and survival.

  2003influential reference
• Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis

  2003cited by this paper
• NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.

  2003cited by this paper
• Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.

  2002cited by this paper
• [Mechanisms of hepatic fibrogenesis].

  2002cited by this paper
• Signal Transduction by the Chemokine Receptor CXCR3

  2001cited by this paper
• Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.

  2001cited by this paper
• Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis.

  1999cited by this paper
• c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.

  1999cited by this paper
• Regulation of extracellular matrix synthesis by transforming growth factor beta 1 in human fat-storing cells.

  1993cited by this paper
• Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate

  1989cited by this paper

• The correlation between obesity and leptin signaling pathways.

  2025cites this paper
• Pirfenidone Downregulates eIF6, P311, and TGF-β Expression and Improves Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats: Evidence for Liver Regeneration

  2024cites this paper
• Role of Leptin and Adiponectin in Carcinogenesis

  2023cites this paper
• Hepatic Myofibroblasts: A Heterogeneous and Redox-Modulated Cell Population in Liver Fibrogenesis

  2022cites this paper
• Lipid based Nanocarriers for effective Drug Delivery and Treatment of Diabetes Associated Liver Fibrosis.

  2021cites this paper
• Non-Alcoholic Fatty Liver Disease: From Pathogenesis to Clinical Impact

  2021cites this paper
• Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis

  2021influential citation
• The hypoxia response and nutritional peptides.

  2021cites this paper
• Non-alcoholic fatty liver disease: An overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions.

  2021cites this paper
• Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis

  2021cites this paper
• Combined alcoholic and non-alcoholic steatohepatitis

  2020cites this paper
• Liver fibrogenesis: UN update on established and emerging basic concepts.

  2020cites this paper
• Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia

  2019cites this paper
• Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase

  2018cites this paper
• Molecular Basis for Pathogenesis of Steatohepatitis: Contemporary Understanding and New Insights

  2018cites this paper
• Adult Non-alcoholic Fatty Liver Disease (NAFLD)

  2018cites this paper
• Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.

  2017cites this paper
• Leptin Attenuates the Contractile Function of Adult Rat Cardiomyocytes Involved in Oxidative Stress and Autophagy.

  2016cites this paper
• Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti‐fibrosis effect by inhibition of mammalian target of rapamycin

  2016cites this paper
• Transcriptomic analysis of the effects of Toll-like receptor 4 and its ligands on the gene expression network of hepatic stellate cells

  2016cites this paper
• The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).

  2016cites this paper
• Liver Fibrosis and Leptin

  2016cites this paper
• Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward.

  2016cites this paper
• Hypoxia-induced secretion of platelet-derived growth factor-BB by hepatocellular carcinoma cells increases activated hepatic stellate cell proliferation, migration and expression of vascular endothelial growth factor-A.

  2015cites this paper
• Cytokine Production and Signaling in Stellate Cells

  2015cites this paper
• 3. Stellate cells

  2015cites this paper
• Oxidative Stress and Liver Fibrogenesis

  2015cites this paper
• Angiogenesis and liver fibrosis.

  2015cites this paper
• Angiogenesis and Fibrogenesis in Chronic Liver Diseases

  2015cites this paper
• Austin Biomarkers & Diagnosis Adipokines in Hepatic Angiogenesis

  2015cites this paper
• Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs)

  2014cites this paper
• Hypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.

  2014influential citation
• Enteral leptin administration affects intestinal autophagy in suckling piglets.

  2014cites this paper
• Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells

  2014cites this paper
• Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update.

  2014cites this paper
• Peroxisome proliferator-activated receptor-&ggr; interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-&bgr; receptor in hepatic stellate cells

  2014cites this paper
• Cellular and molecular mechanisms in liver fibrogenesis.

  2014cites this paper
• Pathophysiology of NASH: perspectives for a targeted treatment.

  2013cites this paper
• Peroxisome proliferator-activated receptor-c interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-b receptor in hepatic stellate cells

  2013influential citation
• Authors and affiliations

  2013cites this paper
• Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic Pathways

  2012cites this paper
• The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis

  2012cites this paper
• Adipokines and Redox Signaling: Impact on Fatty Liver Disease

  2011cites this paper
• 15th International Symposium on Cells of the Hepatic Sinusoid, 2010

  2011cites this paper
• Neuroendocrine regulation of autophagy by leptin

  2011cites this paper