Purification of recombinant baculoviruses for gene therapy using membrane processes

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Gene Therapy

• Publication date

  2009-04-02

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1038/gt.2009.33PMID 19340018
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells

  2009cited by this paper
• Targeting and Purification of Metabolically Biotinylated Baculovirus

  2008cited by this paper
• Advances in Primary Recovery: Centrifugation and Membrane Technology

  2008cited by this paper
• Effects of temperature and shear force on infectivity of the baculovirus Autographa californica M nucleopolyhedrovirus.

  2008cited by this paper
• Rapid Titer Determination of Baculovirus by Quantitative Real‐Time Polymerase Chain Reaction

  2008cited by this paper
• Baculovirus as an expression and/or delivery vehicle for vaccine antigens

  2008cited by this paper
• Purification of recombinant rotavirus VP7 glycoprotein for the study of in vitro rotavirus-like particles assembly.

  2008cited by this paper
• Baculovirus vector for gene delivery and vaccine development

  2008cited by this paper
• High yield purification of functional baculovirus vectors by size exclusion chromatography.

  2007cited by this paper
• Purification of retroviral vectors for clinical application: biological implications and technological challenges.

  2007cited by this paper
• Ion-Exchange Membrane Chromatography Method for Rapid and Efficient Purification of Recombinant Baculovirus and Baculovirus gp64 Protein

  2007cited by this paper
• Baculovirus as a new gene delivery vector for stem cell engineering and bone tissue engineering

  2007cited by this paper
• Baculovirus Vectors for Gene Therapy

  2006cited by this paper
• Analysis of baculovirus aggregates using flow cytometry.

  2006cited by this paper
• A Membrane Chromatography Application: A Rapid, High Capacity Gene Therapy Vector Purification Tool

  2006cited by this paper
• Cell culture technology for pharmaceutical and cell-based therapies

  2005cited by this paper
• Triple layered rotavirus VLP production: kinetics of vector replication, mRNA stability and recombinant protein production.

  2005cited by this paper
• Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques

  2005cited by this paper
• Development of a novel adenovirus purification process utilizing selective precipitation of cellular DNA.

  2005cited by this paper
• Production and formulation of adenovirus vectors.

  2005cited by this paper
• Principles and Applications of the Insect Cell-Baculovirus Expression Vector System

  2005cited by this paper
• A Flow Cytometric Assay for Rapid, Accurate Determination of Baculovirus Titers

  2004cited by this paper
• Food and Drug Administration Center for Biologics Evaluation and Research

  2003cited by this paper
• Baculovirus capsid display: a novel tool for transduction imaging.

  2003cited by this paper
• Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery

  2000cited by this paper
• Characterization and downstream processing of HIV-1 core and virus-like-particles produced in serum free medium

  2000cited by this paper
• Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells

  1999cited by this paper
• Concentration of recombinant baculovirus by cation-exchange chromatography.

  1999cited by this paper
• Quantitative PCR by Continuous Fluorescence Monitoring of a Double Strand DNA Specific Binding Dye

  1998cited by this paper
• The Baculovirus Expression System

  1992cited by this paper
• Baculovirus expression vectors: a laboratory manual.

  1992cited by this paper
• Baculovirus diversity and molecular biology.

  1990cited by this paper

• Development of multivalent SARS-CoV-2 virus-like particle vaccine candidates.

  2025cites this paper
• Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

  2025cites this paper
• Baculovirus purification with functionalized non-woven fibers: Impact of residence time, binding strength, and ligand chemistry

  2025cites this paper
• The downstream bioprocess toolbox for therapeutic viral vectors.

  2023cites this paper
• Evaluating Novel Quantification Methods for Infectious Baculoviruses

  2023cites this paper
• A Combined Ultrafiltration/Diafiltration Process for the Purification of Oncolytic Measles Virus

  2022influential citation
• Bioanalytics for Influenza Virus-Like Particle Characterization and Process Monitoring

  2022cites this paper
• Production of Baculovirus and Stem Cells for Baculovirus-Mediated Gene Transfer into Human Mesenchymal Stem Cells.

  2021cites this paper
• Highly Efficient Purification of Recombinant VSV-∆G-Spike Vaccine against SARS-CoV-2 by Flow-Through Chromatography

  2021cites this paper
• Capture and purification of Human Immunodeficiency Virus-1 virus-like particles: Convective media vs porous beads.

  2020cites this paper
• A Flow-Through Chromatographic Strategy for Hepatitis C Virus-Like Particles Purification

  2020cites this paper
• Opportunities to debottleneck the downstream processing of the oncolytic measles virus

  2020cites this paper
• A scalable downstream process for the purification of the cell culture-derived Orf virus for human or veterinary applications.

  2020cites this paper
• Polysaccharide-based chromatographic adsorbents for virus purification and viral clearance

  2020cites this paper
• Viruses and Virus-Like Particles in Biotechnology: Fundamentals and Applications

  2019cites this paper
• Separation of virus-like particles and extracellular vesicles by flow-through and heparin affinity chromatography.

  2019cites this paper
• Affinity chromatography for vaccines manufacturing: Finally ready for prime time?

  2019cites this paper
• An initiative to manufacture and characterize baculovirus

  2019cites this paper
• Tangential Flow Filtration for the Concentration of Oncolytic Measles Virus: The Influence of Filter Properties and the Cell Culture Medium

  2019cites this paper
• Membrane-Based Steric Exclusion Chromatography for the Purification of a Recombinant Baculovirus and its Application for Cell Therapy.

  2019cites this paper
• Purification of yellow fever virus produced in Vero cells for inactivated vaccine manufacture.

  2019cites this paper
• Efficient filtration strategies for the clarification of influenza virus-like particles derived from insect cells

  2019cites this paper
• Membrane Chromatography for Biomolecule Purification

  2019cites this paper
• New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins

  2018cites this paper
• Gene Therapy.

  2018cites this paper
• Overcome challenges in influenza virus-like particles downstream process

  2017cites this paper
• Manufacturing of AcMNPV baculovirus vectors to enable gene therapy trials

  2016cites this paper
• Stability, biophysical properties and effect of ultracentrifugation and diafiltration on measles virus and mumps virus

  2016cites this paper
• Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

  2016cites this paper
• Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles.

  2016cites this paper
• Tracking Uptake, Assembly and Egress of ACAM529 Herpes Simplex Virus Type 2 in Complementary Vero Cells for Enhanced Virus Recovery

  2016influential citation
• Purification of baculovirus vectors using heparin affinity chromatography

  2016cites this paper
• Exploring insect cells versatility for production of influenza virus-like particles

  2015cites this paper
• Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

  2015cites this paper
• Improved virus purification processes for vaccines and gene therapy

  2015cites this paper
• Filtration methodologies for the clarification and concentration of human mesenchymal stem cells

  2015cites this paper
• Economically optimal batch diafiltration via analytical multi-objective optimal control

  2015cites this paper
• Advances in Model-based Downstream Process Development

  2015cites this paper
• Scalable manufacturing methodologies for improving adeno-associated virus-based pharmaprojects

  2014cites this paper
• Protein production using the baculovirus‐insect cell expression system

  2014cites this paper
• Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study.

  2014cites this paper
• Virus separation using membranes.

  2014cites this paper
• Development and evaluation of baculovirus-expressed Chikungunya virus E1 envelope proteins for serodiagnosis of Chikungunya infection.

  2014cites this paper
• Challenges in Biotherapeutic Development INDUSTRIALIZATION OF mAb PRODUCTION : IMPACT TO CELL CULTURE PROCESS DEVELOPMENT

  2014cites this paper
• Modelling, control, and optimisation of membrane processes

  2014cites this paper
• Investigation of a Novel Hydrogel Anion Exchange Material for the Capture and Purification of Baculovirus

  2014influential citation
• Evaluation of Novel Large Cut-Off Ultrafiltration Membranes for Adenovirus Serotype 5 (Ad5) Concentration

  2014cites this paper
• Fully aseptic single‐use cross flow filtration system for clarification and concentration of cytomegalovirus‐like particles

  2014influential citation
• Baculovirus as a gene delivery and expression vector in mammalian cells

  2014cites this paper
• Industrial Large Scale of Suspension Culture of Insect Cells

  2014cites this paper
• Control and optimization of solute transport in a thin porous tube

  2013cites this paper
• Validation Study in Membrane Chromatography Adsorber and Phenyl Hydrophobic Membrane Chromatography Adsorber for Virus Clearanceand Removal of Many Other Components

  2013cites this paper
• Optimal balancing of temporal and buffer costs for ultrafiltration/diafiltration processes under limiting flux conditions

  2013cites this paper
• Membrane Supported Virus Separation from Biological Solutions

  2013cites this paper
• Recent advances in bioprocessing application of membrane chromatography.

  2013cites this paper
• Purification of complex biopharmaceuticals with new processes, advanced analytics and computer-aided process design tools

  2013cites this paper
• Baculovirus: an insect-derived vector for diverse gene transfer applications.

  2013cites this paper
• Plant-derived virus-like particles as vaccines

  2013cites this paper
• Purification of infective baculoviruses by monoliths.

  2013cites this paper
• Evaluating Baculovirus as a Vector for Human Prostate Cancer Gene Therapy

  2013cites this paper
• Purification of a recombinant baculovirus of Autographa californica M nucleopolyhedrovirus by ion exchange membrane chromatography.

  2012influential citation
• Overview of current scalable methods for purification of viral vectors.

  2011cites this paper
• An initiative to manufacture and characterize baculovirus reference material.

  2011cites this paper
• Nonintegrating DNA Virus

  2011cites this paper
• Production and purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors

  2011cites this paper
• Impact of ligand density on the optimization of ion‐exchange membrane chromatography for viral vector purification

  2011cites this paper
• Baculovirus as vectors for human cells and applications in organ transplantation.

  2011cites this paper
• Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

  2011cites this paper
• Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: current advances.

  2011cites this paper
• Viruses and Virus-Like Particles in Biotechnology

  2011cites this paper
• Development and validation of a HPLC method for the quantification of baculovirus particles.

  2011cites this paper
• Strategies for the purification and characterization of protein scaffolds for the production of hybrid nanobiomaterials.

  2011cites this paper
• Baculovirus-Produced Influenza Virus-like Particles in Mammalian Cells Protect Mice from Lethal Influenza Challenge

  2011cites this paper
• Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases.

  2011cites this paper
• Quality control and analytical methods for baculovirus-based products.

  2011cites this paper
• Virus-Like Particle Vaccines: Advantages and Challenges

  2011cites this paper
• Insect cell technology is a versatile and robust vaccine manufacturing platform

  2011cites this paper
• Requirements for baculoviruses for clinical gene therapy applications.

  2011cites this paper
• Baculoviruses as gene therapy vectors for human prostate cancer.

  2011cites this paper
• In vivo application and tracking of baculovirus.

  2010cites this paper
• Potential cancer gene therapy by baculoviral transduction.

  2010cites this paper
• Virus-like particles in vaccine development

  2010cites this paper
• Analysis of adsorption of a baculovirus bioreaction bulk on an ion-exchange surface by surface plasmon resonance.

  2010cites this paper
• Modeling protein binding and elution over a chromatographic surface probed by surface plasmon resonance.

  2010cites this paper
• Modeling electrostatic interactions of baculovirus vectors for ion-exchange process development.

  2010cites this paper
• Bioprocessing of baculovirus vectors: a review.

  2010cites this paper
• Baculovirus gene delivery: a flexible assay development tool.

  2010cites this paper
• Lentiviral Vectors for Gene Therapy Targeting, Imaging and Baculovirus Mediated New Method for Lentivirus Production

  2009cites this paper
• Targeting and Purification of Metabolically Biotinylated Baculovirus

  2008cites this paper
• 21-X8 Final report

  year unknowncites this paper