Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Neuropharmacology

• Publication date

  1985-05-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/0028-3908(85)90026-7PMID 2991800
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Drugs affecting brain dopamine interfere with the effect of Z-prolyl-D-leucine on morphine withdrawal.

  1984cited by this paper
• The mesolimbic nucleus accumbens is critically involved with the mediation of the motor inhibitory and facilitatory effects of dopamine agonists on mouse spontaneous climbing behaviour.

  1983cited by this paper
• Catecholamine utilization in distinct mouse brain nuclei during acute morphine treatment, morphine tolerance and withdrawal syndrome.

  1983cited by this paper
• METABOLITES OF ARGININE-VASOPRESSIN AND OXYTOCIN ARE HIGHLY POTENT NEUROPEPTIDES IN THE BRAIN

  1983cited by this paper
• Oxytocin is a precursor of potent behaviourally active neuropeptides.

  1983cited by this paper
• Binding of [3H]spiroperidol to striatal membranes of rats treated chronically with morphine. Influence of Pro-Leu-Gly-NH2 and cyclo(Leu-Gly).

  1983cited by this paper
• Influence of Z-Prolyl-D-Leucine on alpha-MPT-induced catecholamine utilization in specific mouse brain nuclei.

  1983cited by this paper
• Role of oxytocin in memory and amnesia.

  1982cited by this paper
• Neurohypophyseal Hormones and Memory

  1982cited by this paper
• Dose-related effect of the oxytocin fragment (prolyl-leucyl-glycinamide) on ?-MPT-induced catecholamine disappearance and serotonin level in rat brain.

  1981cited by this paper
• On the mode of action of an oxytocin derivative (Z-Pro-D-Leu) on morphine-dependence in mice.

  1981cited by this paper
• Catecholamine receptor supersensitivity and subsensitivity in the central nervous system.

  1980cited by this paper
• Opioid Dependence

  1980cited by this paper
• Inhibition of neuroleptic-induced dopamine receptor supersensitivity by cyclo (Leu-Gly).

  1980cited by this paper
• Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists.

  1979cited by this paper
• Tolerance to and physical dependence on morphine in mice.

  1978cited by this paper
• Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes.

  1978cited by this paper
• Failure vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development.

  1978cited by this paper
• Site of action of development of partial tolerance to morphine in cats.

  1977cited by this paper
• Effect of neurohypophyseal hormones on morphine dependence.

  1977cited by this paper
• Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor activity in rats.

  1976cited by this paper
• Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments.

  1976cited by this paper
• Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

  1976cited by this paper
• Evidence from rats that morphine tolerance is a learned response.

  1975cited by this paper
• Facilitation of development of resistance to morphine analgesia by desglycinamide9-lysine vasopressin.

  1974cited by this paper
• A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

  1941cited by this paper

• Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain

  2025cites this paper
• Postnatal oxytocin treatment improves survival and neurodevelopmental outcomes in an animal model of neonatal abstinence syndrome

  2022cites this paper
• Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

  2022cites this paper
• Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward

  2021cites this paper
• Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges.

  2021cites this paper
• Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.

  2020cites this paper
• The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy.

  2020cites this paper
• The addictive appetite model of Bulimia Nervosa and Binge Eating Disorder : a synthesis of basic science and clinical evidence for a new maintenance model of recurrent binge eating

  2019cites this paper
• Opioids and the hormone oxytocin.

  2019cites this paper
• The Other Face of Oxytocin : Role of Oxytocin in Neuropsychiatric Disorders

  2019cites this paper
• University of Surrey

  2019cites this paper
• Oxytocin and opioid addiction revisited: old drug, new applications

  2018cites this paper
• Oxytocin Reduces Cocaine Cued Fos Activation in a Regionally Specific Manner

  2017cites this paper
• Oxytocin, Tolerance, and the Dark Side of Addiction.

  2017cites this paper
• Oxytocin’s Effects in Cocaine and Other Psychostimulant Addictions

  2017cites this paper
• Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine‐seeking behaviour in rats

  2016cites this paper
• Oxytocin decreases cocaine taking, cocaine seeking, and locomotor activity in female rats.

  2016cites this paper
• Chronic Methamphetamine Self‐Administration Dysregulates Oxytocin Plasma Levels and Oxytocin Receptor Fibre Density in the Nucleus Accumbens Core and Subthalamic Nucleus of the Rat

  2016cites this paper
• Oxytocin for the treatment of drug and alcohol use disorders

  2016cites this paper
• The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study

  2016cites this paper
• The neurocircuitry involved in oxytocin modulation of methamphetamine addiction.

  2016cites this paper
• The Effect of Oxytocin on Methamphetamine Addiction

  2016cites this paper
• Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

  2016cites this paper
• The Involvement of Oxytocin in the Subthalamic Nucleus on Relapse to Methamphetamine-Seeking Behaviour

  2015cites this paper
• The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

  2014cites this paper
• Oxytocin Reduces Cocaine Seeking and Reverses Chronic Cocaine-Induced Changes in Glutamate Receptor Function

  2014cites this paper
• Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus.

  2013cites this paper
• A brief history of oxytocin and its role in modulating psychostimulant effects

  2013influential citation
• Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference.

  2012cites this paper
• Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner.

  2012cites this paper
• Acute morphine administration and withdrawal from chronic morphine increase afterdepolarization amplitude in rat supraoptic nucleus neurons in hypothalamic explants.

  2011cites this paper
• Morphine withdrawal increases intrinsic excitability of oxytocin neurons in morphine‐dependent rats

  2005cites this paper
• Limbic oxytocin and arginine8-vasopressin in morphine tolerance and dependence

  2004cites this paper
• Oxytocin diminishes heroin tolerance in mice

  2004cites this paper
• Oxytocin-induced penile erection and yawning in male rats: effect of neonatal monosodium glutamate and hypophysectomy

  2004cites this paper
• Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats.

  2001cites this paper
• Brain uptake and the analgesic effect of oxytocin— Its usefulness as an analgesic agent

  2000cites this paper
• Chronic morphine treatment inhibits oxytocin synthesis in rats

  2000cites this paper
• Oxytocin and neuroadaptation to cocaine.

  1998cites this paper
• Effects of brain natriuretic peptide on effects of morphine in mice.

  1996cites this paper
• Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.

  1996cites this paper
• Effects of intrahypothalamic morphine and its interactions with oxytocin and vasopressin during food intake in rats.

  1995cites this paper
• Effects of secretin on acute and chronic effects of morphine.

  1995cites this paper
• Intrathecal oxytocin facilitates the spinal nociceptive flexor reflex in the rat.

  1994cites this paper
• Role of oxytocin in the neuroadaptation to drugs of abuse.

  1994cites this paper
• Is systemically administered oxytocin an analgesic in rats?

  1994cites this paper
• Neurohypophysial Peptides and Brain Neurochemistry

  1993cites this paper
• Neurohypophysial Peptides in Opiate Withdrawal and Tolerance

  1993cites this paper
• Transfer of [3H]leucine across the blood-brain barrier at high blood-side oxytocin concentrations in normal and morphine-dependent rats.

  1992cites this paper
• Effects of acute and chronic ketocyclazocine and its modulation by oxytocin or vasopressin on food intake in rats.

  1992cites this paper
• Oxytocin modulates behavioural adaptation to repeated treatment with cocaine in rats.

  1992cites this paper
• Development of acute morphine tolerance in peripheral clinico-chemical parameters.

  1991cites this paper
• Effects of the oxytocin fragment prolyl-leucyl-glycinamide on sexual behavior in the rat.

  1991cites this paper
• Selective attenuation of cocaine-induced stereotyped behaviour by oxytocin: putative role of basal forebrain target sites.

  1991cites this paper
• Central functions of oxytocin.

  1991cites this paper
• Effects of acute and chronic morphine on food intake in rats: modulation by oxytocin and vasopressin.

  1991cites this paper
• The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity.

  1990cites this paper
• Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats.

  1990cites this paper
• Conformational and structural considerations in oxytocin-receptor binding and biological activity.

  1990cites this paper
• Oxytocin-induced motor disturbances: relationship with penile erection and yawning.

  1989cites this paper
• Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system.

  1989cites this paper
• Central effects of the potent and highly selective μ opioid antagonist (CTOP) in mice

  1988cites this paper
• Oxytocin: neurobiologic considerations and their implications for affective illness.

  1988cites this paper
• Endogenous oxytocin inhibits morphine tolerance through limbic forebrain oxytocin receptors.

  1988cites this paper
• Analgesic and tolerance-inducing effects of the highly selective δ opioid agonist enkephalin in mice

  1988cites this paper
• Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.

  1988cites this paper
• Analgesic and tolerance-inducing effects of the highly selective delta opioid agonist [D-Pen2,D-Pen5]enkephalin in mice.

  1988cites this paper
• Hypothalamo-neurohypophyseal neuropeptides and experimental drug addiction.

  1988cites this paper
• Beta-endorphin tolerance is inhibited by oxytocin.

  1987cites this paper
• C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol.

  1987cites this paper
• Tawning: Neurochemistry, Physiology And Pathology

  1987cites this paper
• Neurohypophyseal hormones and behavior.

  1987cites this paper
• Microinjection of oxytocin into limbic-mesolimbic brain structures disrupts heroin self-administration behavior: a receptor-mediated event?

  1987cites this paper
• Effects of oxytocin-related peptides on acute morphine tolerance: opposite actions by oxytocin and its receptor antagonists.

  1987cites this paper
• β-endorphin tolerance is inhibited by oxytocin

  1987cites this paper
• INFLUENCE OF OXYTOCIN AND AN ANALOG ANTAGONIST OF OXYTOCIN ON THE DEVELOPMENT OF ACUTE MORPHINE TOLERANCE IN MICE

  1986cites this paper
• Neurobiology of Oxytocin

  1986cites this paper
• Oxytocin and Behavior

  1986cites this paper
• BEHAVIORALLY ACTIVE OXYTOCIN FRAGMENTS DIMINISH INTRAVENOUS SELF-ADMINISTRATION OF HEROIN IN HEROIN-TOLERANT RATS

  1986cites this paper
• Peripheral oxytocin treatment modulates central dopamine transmission in the mouse limbic structures.

  1986cites this paper
• Development of morphine tolerance under tonic control of brain oxytocin.

  1986cites this paper
• Effect of oxytocin on acute enkephalin tolerance in mice.

  1986cites this paper
• Disturbance of motoric function as behavioral measure of impaired cerebral circulation in mice.

  1986cites this paper
• Oxytocin: an extremely potent inducer of penile erection and yawning in male rats.

  1986cites this paper
• d-pipecolic acid inhibits ethanol tolerance in mice

  1986cites this paper
• Oxytocin-induced penile erection and yawning: site of action in the brain.

  1986cites this paper
• Acute morphine treatment and morphine tolerance/dependence alter immunoreactive oxytocin levels in the mouse hippocampus.

  1985cites this paper
• Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system.

  1984cites this paper