The mineralization phenotype in Abcc6−/− mice is affected by Ggcx gene deficiency and genetic background—a model for pseudoxanthoma elasticum

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of molecular medicine

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00109-009-0522-8PMID 19784827PMCID PMC2879630
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nonparametric Statistics for the Behavioral Sciences

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• Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)).

  2009influential reference
• Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.

  2009influential reference
• Angioid streaks, clinical course, complications, and current therapeutic management

  2009cited by this paper
• Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene.

  2009influential reference
• Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms

  2009influential reference
• Angioid streaks, clinical course, complications, and current therapeutic management

  2008cited by this paper
• Ectopic mineralization of connective tissue in Abcc6–/– mice: effects of dietary modifications and a phosphate binder – a preliminary study

  2008cited by this paper
• Pseudoxanthoma elasticum: oxidative stress and antioxidant diet in a mouse model (Abcc6-/-).

  2008cited by this paper
• Does the absence of ABCC6 (Multidrug Resistance Protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?

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• Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset.

  2007cited by this paper
• Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors.

  2007cited by this paper
• Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity.

  2007influential reference
• Fatal hemorrhage in mice lacking γ-glutamyl carboxylase

  2007cited by this paper
• Mutation detection in the ABCC6 gene and genotype–phenotype analysis in a large international case series affected by pseudoxanthoma elasticum

  2007cited by this paper
• Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients

  2007cited by this paper
• SPP1 promoter polymorphisms: identification of the first modifier gene for pseudoxanthoma elasticum.

  2007cited by this paper
• Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

  2007cited by this paper
• Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course

  2006cited by this paper
• Pseudoxanthoma elasticum is a recessive disease characterized by compound heterozygosity.

  2006cited by this paper
• The vitamin K-dependent carboxylase.

  2005cited by this paper
• Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues

  2005influential reference
• Acquired Pseudoxanthoma elasticum‐like syndrome in β‐thalassaemia patients

  2003cited by this paper
• Loss of ATP-dependent Transport Activity in Pseudoxanthoma Elasticum-associated Mutants of Human ABCC6 (MRP6)*

  2002cited by this paper
• MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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• A 500-kb region on chromosome 16p13.1 contains the pseudoxanthoma elasticum locus: high-resolution mapping and genomic structure

  2000cited by this paper
• Pseudoxanthoma elasticum maps to an 820-kb region of the p13.1 region of chromosome 16.

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• Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

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• Exclusion of an elastin gene (ELN) mutation as the cause of pseudoxanthoma elasticum (PXE) in one family

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• Connective tissue and its heritable disorders —Molecular, genetic and medical aspects

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• Workshop on pseudoxanthoma elasticum: molecular biology and pathology of the elastic fibers. Jefferson Medical College, Philadelphia, Pennsylvania, June 10, 1992.

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• Heritable Disorders of Connective Tissues

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• Pseudoxanthoma Elasticum

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• The Purinergic Nature of Pseudoxanthoma Elasticum

  2024cites this paper
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  2022cites this paper
• From membrane to mineralization: the curious case of the ABCC6 transporter

  2020cites this paper
• Molecular Genetics and Modifier Genes in Pseudoxanthoma Elasticum, a Heritable Multisystem Ectopic Mineralization Disorder.

  2020cites this paper
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  2020cites this paper
• PXE, a Mysterious Inborn Error Clarified.

  2019cites this paper
• Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders: Pathomechanisms and Treatment Development.

  2019cites this paper
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  2018cites this paper
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  2017cites this paper
• Deciphering Ectopic Calcification: Contribution of the Rare, Inherited Disorder Pseudoxanthoma Elasticum

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• DEV113811 1095..1101

  2015cites this paper
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• Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients with NT5E mutations

  2014cites this paper
• Retinitis pigmentosa, cutis laxa, and pseudoxanthoma elasticum-like skin manifestations associated with GGCX mutations.

  2014cites this paper
• Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: The Abcc6tm1Jfk and Enpp1asj mutant mice

  2014cites this paper
• Mouse Models for Pseudoxanthoma Elasticum: Genetic and Dietary Modulation of the Ectopic Mineralization Phenotypes

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Mineralization/anti-mineralization networks in the skin and vascular connective tissues.

  2013cites this paper
• Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.

  2013cites this paper
• New insights into the pathogenesis of pseudoxanthoma elasticum and related soft tissue calcification disorders by identifying genetic interactions and modifiers

  2013cites this paper
• Chapter 155 – Heritable Diseases Affecting the Elastic Fibers: Cutis Laxa, Pseudoxanthoma Elasticum, and Related Disorders

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2010cites this paper
• Modifier genes in pseudoxanthoma elasticum: novel insights from the Ggcx mouse model

  2010cites this paper
• Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms.

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• CARDIOVASCULAR , PULMONARY , AND RENAL PATHOLOGY The Level of Hepatic ABCC 6 Expression Determines the Severity of Calci fi cation after Cardiac Injury

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