Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials.

Imidazolidin-4-one derivatives of primaquine were synthesized as potential double prodrugs of the parent drug. The title compounds inhibit the development of the sporogonic cycle of Plasmodium berghei, affecting the appearance of oocysts in the midguts of the mosquitoes. The imidazolidin-4-ones are very stable, both in human plasma and in pH 7.4 buffer, indicating that they are active per se. Thus, imidazolidin-4-ones derived from 8-aminoquinolines represent a new entry in antimalarial structure-activity relationships.

• Publication year

  2005

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2005-01-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM0494624PMID 15689174
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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