Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neurobiology of Aging

• Publication date

  2013-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neurobiolaging.2012.12.015PMID 23481568PMCID PMC3596824
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• α-Synuclein: membrane interactions and toxicity in Parkinson's disease.

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• The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

  2010cited by this paper
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  2009influential reference
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• An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease.

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• Subcellular localization of disease-associated prion protein in the human brain.

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  1999cited by this paper
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  1999cited by this paper
• Prion biology and diseases.

  1999cited by this paper
• Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions.

  1999cited by this paper
• Severe, Early and Selective Loss of a Subpopulation of GABAergic Inhibitory Neurons in Experimental Transmissible Spongiform Encephalopathies

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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

  1992cited by this paper
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  1992cited by this paper
• N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

  1991cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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  1984cited by this paper
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  year unknowncited by this paper

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