Application of exogenously regulatable promoter systems to transgenic models for the study of aging.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  The journals of gerontology. Series A, Biological sciences and medical sciences

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/GERONA/54.1.B30PMID 10026653
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Controlling your losses: conditional gene silencing in mammals.

  1998cited by this paper
• Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator

  1997cited by this paper
• Transgenic expression of hepatitis C virus structural proteins in the mouse

  1997cited by this paper
• Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.

  1997cited by this paper
• Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential.

  1997cited by this paper
• Ligand-inducible and liver-specific target gene expression in transgenic mice

  1997cited by this paper
• Partial transfection of liver with a synthetic cholesterol 7 alpha-hydroxylase transgene is sufficient to stimulate the reduction of cholesterol in the plasma of hypercholesterolemic mice.

  1997cited by this paper
• The acute promyelocytic leukemia PML-RARα protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice

  1997cited by this paper
• Diverse strategies for tetracycline-regulated inducible gene expression.

  1996cited by this paper
• Requirement of mammalian DNA polymerase-β in base-excision repair

  1996cited by this paper
• Neuron-specific Gene Expression of Synapsin I

  1996cited by this paper
• Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

  1996cited by this paper
• HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene.

  1996cited by this paper
• Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

  1996cited by this paper
• Antiatherogenic properties of zinc: implications in endothelial cell metabolism.

  1996cited by this paper
• Aging and oxidative stress: modulation by dietary restriction.

  1996cited by this paper
• Requirement of mammalian DNA polymerase-β in base-excision repair

  1996cited by this paper
• Requirement of mammalian DNA polymerase-beta in base-excision repair.

  1996cited by this paper
• Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

  1996cited by this paper
• Time-Sensitive Reversal of Hyperplasia in Transgenic Mice Expressing SV40 T Antigen

  1996cited by this paper
• Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice

  1996cited by this paper
• Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

  1996influential reference
• The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

  1995cited by this paper
• Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle

  1995cited by this paper
• Human cytomegalovirus (HCMV) immediate-early enhancer/promoter specificity during embryogenesis defines target tissues of congenital HCMV infection

  1995cited by this paper
• Transcriptional activation by tetracyclines in mammalian cells.

  1995cited by this paper
• Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene.

  1995cited by this paper
• Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

  1995cited by this paper
• A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

  1995cited by this paper
• Tetracycline-reversible silencing of eukaryotic promoters

  1995cited by this paper
• Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

  1994influential reference
• Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

  1994cited by this paper
• Murine PGK‐1 promoter drives widespread but not uniform expression in transgenic mice

  1994cited by this paper
• Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements.

  1994cited by this paper
• Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

  1994cited by this paper
• The 5' flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic mice.

  1994cited by this paper
• Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia.

  1994cited by this paper
• Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein.

  1994cited by this paper
• Tetracycline-regulated cardiac gene expression in vivo.

  1994cited by this paper
• A regulatory system for use in gene transfer.

  1994cited by this paper
• Regulated expression of foreign genes in vivo after germline transfer.

  1994cited by this paper
• Krüppel-associated boxes are potent transcriptional repression domains.

  1994cited by this paper
• The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

  1994cited by this paper
• MyoD or Myf-5 is required for the formation of skeletal muscle.

  1993cited by this paper
• The biochemical basis of zinc physiology.

  1993cited by this paper
• Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB.

  1993cited by this paper
• Expression of a retinoblastoma transgene results in dwarf mice.

  1993cited by this paper
• Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

  1992cited by this paper
• Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

  1992influential reference
• The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice.

  1991cited by this paper
• Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor

  1991cited by this paper
• Comparative toxicity and carcinogenicity studies of tetracycline and oxytetracycline in rats and mice.

  1991cited by this paper
• Reduced binding of TFIID to transcriptionally compromised mutants of VP16

  1991cited by this paper
• Binding of general transcription factor TFIIB to an acidic activating region

  1991cited by this paper
• Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.

  1990cited by this paper
• Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

  1990cited by this paper
• LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

  1990cited by this paper
• Distribution of RU 486 and its demethylated metabolites in humans.

  1989cited by this paper
• Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

  1989cited by this paper
• Protein Nucleic Acid Interaction

  1989cited by this paper
• Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

  1988cited by this paper
• Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells.

  1988cited by this paper
• GAL4-VP16 is an unusually potent transcriptional activator

  1988cited by this paper
• Dynamics of repressor-operator recognition: the Tn10-encoded tetracycline resistance control.

  1988cited by this paper
• The inducible Iac operator-repressor system is functional in mammalian cells

  1987cited by this paper
• Goodman and Gilman's the Pharmacological Basis of Therapeutics

  1986cited by this paper
• Nucleotide sequence of the repressor gene of the TN10 tetracycline resistance determinant.

  1984cited by this paper
• Control of expression of the Tn10-encoded tetracycline resistance genes. Equilibrium and kinetic investigation of the regulatory reactions.

  1983cited by this paper
• Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids

  1981cited by this paper

• Biological Aging

  2013influential citation
• Methods of testing pharmacological drugs effects on aging and life span in mice.

  2013cites this paper
• Methods of evaluating the effect of pharmacological drugs on aging and life span in mice.

  2007cites this paper
• Visual Attention and Older Drivers: The Contribution of Inhibition of Return to Safe Driving

  2006cites this paper
• Approaches for cardiovascular gene therapy in animal models

  2006cites this paper
• The aging factor in health and disease: The promise of basic research on aging

  2004cites this paper
• Aging and cancer in transgenic and mutant mice.

  2003cites this paper
• Practical uses for ecdysteroids in mammals including humans: an update

  2003cites this paper
• A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice.

  2003cites this paper
• A novel strategy for regulated expression of a cytotoxic gene.

  2001cites this paper
• Mouse models for sporadic cancer.

  2001cites this paper
• Genetically engineered mice and their use in aging research

  2001cites this paper
• Phytoecdysteroids: biological aspects.

  2001cites this paper
• Caloric restriction mimetics: metabolic interventions.

  2001cites this paper
• Tailoring cancer vaccines to the elderly: the importance of suitable mouse models.

  2001cites this paper
• Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis.

  2001cites this paper
• Tetracycline-inducible system for photoreceptor-specific gene expression.

  2000cites this paper
• Design of retroviral vectors and helper cells for gene therapy.

  2000cites this paper