Nutrient availability links mitochondria, apoptosis, and obesity

Mitochondria are the dominant source of the cellular energy requirements through oxidative phosphorylation, but they are also central players in apoptosis. Nutrient availability may have been the main evolutionary driving force behind these opposite mitochondrial functions: production of energy to sustain life and release of apoptotic proteins to trigger cell death. Here, we explore the link between nutrients, mitochondria and apoptosis with known and potential implications for age-related decline and metabolic syndromes.

• Publication year

  2012

• Venue

  Aging

• Publication date

  2012-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.18632/AGING.100505PMID 23211444PMCID 3560440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

  2012cited by this paper
• mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

  2012cited by this paper
• TAp73 depletion accelerates aging through metabolic dysregulation.

  2012cited by this paper
• Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity

  2012cited by this paper
• Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

  2011cited by this paper
• Caspases and cancer

  2011cited by this paper
• Genetically defining the mechanism of Puma- and Bim-induced apoptosis

  2011cited by this paper
• Therapeutic targets in cancer cell metabolism and death

  2011cited by this paper
• Cell death pathology: the war against cancer.

  2011cited by this paper
• Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

  2011cited by this paper
• Morphological classification of plant cell deaths

  2011cited by this paper
• Type 2 Diabetes and the Aging Pancreatic Beta Cell

  2011cited by this paper
• Mitochondrial longevity pathways.

  2011cited by this paper
• Telomere dysfunction induces metabolic and mitochondrial compromise

  2011cited by this paper
• The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.

  2011influential reference
• The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

  2011cited by this paper
• Apoptosis: Physiology and Pathology

  2011cited by this paper
• Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat

  2011cited by this paper
• Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

  2011cited by this paper
• Caloric restriction.

  2011influential reference
• Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

  2011cited by this paper
• Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

  2011cited by this paper
• Metacaspases

  2011cited by this paper
• Bcl-2 family interaction with the mitochondrial morphogenesis machinery

  2011cited by this paper
• Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

  2011cited by this paper
• Why Cell Reprogramming is Functionally Linked to Aging?

  2011cited by this paper
• NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons

  2011cited by this paper
• Mitochondrial longevity pathways.

  2011cited by this paper
• Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death

  2011cited by this paper
• Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

  2011cited by this paper
• Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

  2011cited by this paper
• Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

  2011cited by this paper
• Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

  2011cited by this paper
• Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

  2011cited by this paper
• Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

  2011cited by this paper
• Aging: Dial M for Mitochondria

  2010cited by this paper
• Smac/DIABLO release from the mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation

  2010cited by this paper
• BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis

  2010cited by this paper
• Metabolic regulation of stem cell behavior and implications for aging.

  2010cited by this paper
• Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

  2010cited by this paper
• Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin

  2010cited by this paper
• Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2

  2010cited by this paper
• The sweet taste of death: glucose triggers apoptosis during yeast chronological aging

  2010cited by this paper
• Adult-onset, short-term dietary restriction reduces cell senescence in mice

  2010cited by this paper
• Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

  2010cited by this paper
• Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

  2010cited by this paper
• Molecular mechanisms of late apoptotic/necrotic cell clearance

  2010cited by this paper
• Apoptosis and the yeast actin cytoskeleton

  2010cited by this paper
• Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies

  2010cited by this paper
• New insights into the role of mitochondria in aging: mitochondrial dynamics and more

  2010cited by this paper
• Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.

  2010cited by this paper
• Cell death in yeast: growing applications of a dying buddy

  2010cited by this paper
• Survivin and IAP proteins in cell-death mechanisms.

  2010cited by this paper
• Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

  2010cited by this paper
• Mitochondria in cell death.

  2010cited by this paper
• Mitochondria and cell death: outer membrane permeabilization and beyond

  2010cited by this paper
• Extending Healthy Life Span—From Yeast to Humans

  2010cited by this paper
• Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation

  2010cited by this paper
• Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells

  2010cited by this paper
• BCL-2: pro-or anti-oxidant?

  2009cited by this paper
• 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

  2009influential reference
• breast cancer cells

  2009cited by this paper
• BH3 Response Profiles From Neuroblastoma Mitochondria Predict Activity of Small Molecule Bcl-2 Family Antagonists

  2009cited by this paper
• Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis*

  2009cited by this paper
• Bmi1 regulates mitochondrial function and the DNA damage response pathway

  2009cited by this paper
• Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.

  2009cited by this paper
• Features of Programmed Cell death in Intact Xenopus Oocytes and Early Embryos Revealed by Near-Infrared Fluorescence and Real-time Monitoring

  2009cited by this paper
• Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.

  2008influential reference
• How mitochondria produce reactive oxygen species

  2008influential reference
• Mitochondrial dysfunction as a cause of ageing

  2008cited by this paper
• Proteomics of mitochondrial inner and outer membranes

  2008influential reference
• Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

  2008cited by this paper
• Transcriptional control of energy homeostasis through the PGC1 coactivators.

  2007cited by this paper
• Caspase function in programmed cell death

  2007cited by this paper
• Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

  2005influential reference
• Mitochondria, oxidants, and aging.

  2005cited by this paper
• Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

  2005cited by this paper
• Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.

  2005cited by this paper
• Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

  2005cited by this paper
• Apoptosis in muscle atrophy: relevance to sarcopenia.

  2005cited by this paper
• Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

  2005cited by this paper
• Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

  2005cited by this paper
• The organization and inheritance of the mitochondrial genome

  2005cited by this paper
• The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system.

  2005cited by this paper
• Premature ageing in mice expressing defective mitochondrial DNA polymerase

  2004cited by this paper
• The evolution of cell death programs as prerequisites of multicellularity.

  2003cited by this paper
• Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

  2003cited by this paper
• Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

  2002cited by this paper
• Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

  2002cited by this paper
• The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

  2001cited by this paper
• Caspase structure, proteolytic substrates, and function during apoptotic cell death

  1999cited by this paper
• Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers.

  1998influential reference
• Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

  1997cited by this paper
• Regulation of apoptosis in the immune system.

  1994cited by this paper
• The mitochondrial electron transport and oxidative phosphorylation system.

  1985influential reference
• Respiratory enzymes in oxidative phosphorylation. II. Difference spectra.

  1955cited by this paper
• Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization.

  1955influential reference

• Calorie Restriction Extends Lifespan in Yeast Independently of GCN5

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• Multidimensional risk impact of obesity on breast cancer incidence, treatment, and prognosis.

  2026cites this paper
• Repeatability and Variability of a High-Fat High-Fructose Diet-Induced Metabolic Syndrome Model in Young Adult Male Wistar Rats

  2026cites this paper
• Transcriptomic profiling reveals neural–immune–stromal dysregulation and risk-associated gene signatures in advanced keratoconus

  2025cites this paper
• Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES

  2025cites this paper
• Association of the triglyceride-glucose index and its combination with obesity indices with cardio-renal-metabolic multimorbidity: two decades of follow-up in the Tehran Lipid and Glucose Study

  2025cites this paper
• Triglyceride glucose-weight-adjusted waist index as a cardiovascular mortality predictor: incremental value beyond the establishment of TyG-related indices

  2025cites this paper
• Nutri-epigenetics of mitochondrial function and energy homeostasis in obesity

  2025cites this paper
• Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice

  2024cites this paper
• Thinned young apple powder prevents obesity-induced neuronal apoptosis via improving mitochondrial function of cerebral cortex in mice.

  2024cites this paper
• Mitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review

  2024cites this paper
• Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity.

  2024cites this paper
• Deciphering the aging process through single‐cell cytometric technologies

  2024cites this paper
• Mitochondrien und Orthomolekularmedizin: neue Perspektiven in der Behandlung des Fibromyalgie-Syndroms

  2024cites this paper
• Anterior Pituitary Transcriptomics Following a High Fat Diet: Impact of oxidative stress on cell metabolism.

  2023cites this paper
• Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.

  2022cites this paper
• Mitochondrial changes in fish cells in vitro in response to serum deprivation

  2022cites this paper
• Oxidative Stress, Plant Natural Antioxidants, and Obesity

  2021cites this paper
• Ferroptosis Regulation by Nutrient Signalling

  2021cites this paper
• Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging

  2021cites this paper
• Exenatide Attenuates Obesity-Induced Mitochondrial Dysfunction by Activating SIRT1 in Renal Tubular Cells

  2021cites this paper
• Abnormal mitochondrial metabolism in obesity and insulin resistance

  2021cites this paper
• The potential effect mechanism of high-fat and high-carbohydrate diet-induced obesity on anxiety and offspring of zebrafish

  2021cites this paper
• Feeding level regulates the expression of some genes involved with programed cell death and remodeling in goat and sheep mammary tissue

  2020cites this paper
• Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway

  2019cites this paper
• Obesity May Accelerate the Aging Process

  2019cites this paper
• Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties

  2019cites this paper
• Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice.

  2019cites this paper
• Metabolites in visceral fat: useful signals of metabolic syndrome?

  2018cites this paper
• Mitochondrial dysfunction in obesity

  2018cites this paper
• The impact of obesity on neurodegenerative diseases

  2017cites this paper
• Fluorescence imaging-based analysis of the mitochondrial permeability transition pore opening in cardiomyocyte-derived H9c2 cells

  2017cites this paper
• Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues.

  2017cites this paper
• Thoracic gamma irradiation-induced obesity in C57BL/6 female mice

  2017cites this paper
• Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity.

  2017cites this paper
• Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells

  2016cites this paper
• Exogenous hydrogen sulfide restores cardiac function after trauma-hemorrhagic shock by inhibiting mitochondrial apoptosis

  2016cites this paper
• Obesity‐driven alterations in adipose‐derived stem cells are partially restored by weight loss

  2016cites this paper
• Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem Cells from Obese Mouse and Human

  2015cites this paper
• Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors.

  2015cites this paper
• Comparative Proteome Analysis of Brown Adipose Tissue in Obese C57BL/6J Mice Using iTRAQ-Coupled 2D LC-MS/MS

  2015cites this paper
• Enhanced oxidative stress sensitizes the mitochondrial permeability transition pore to opening in heart from Zucker Fa/fa rats with type 2 diabetes.

  2015cites this paper
• Evaluation of chromosomal damage, cytostasis, cytotoxicity, oxidative DNA damage and their association with body-mass index in obese subjects.

  2014cites this paper
• Lipid Replacement Therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function.

  2014cites this paper
• In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines

  2014cites this paper
• Molecular Insights into Appetite Control and Neuroendocrine Disease as Risk Factors for Chronic Diseases in Western Countries

  2013cites this paper
• Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

  2013cites this paper
• Cellular flavoprotein fluorescence imaging for the analysis of mitochondrial function

  2013cites this paper
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